Motif ID: Egr3

Z-value: 0.786


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_700774450.736.7e-05Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_49214954 3.544 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr7_-_119184374 3.473 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr7_-_144939823 2.808 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr4_-_41695935 2.726 ENSMUST00000145379.1
 Cntfr
ciliary neurotrophic factor receptor
chr11_+_98937669 2.508 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr17_+_87282880 2.497 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr17_-_87282793 2.276 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr8_+_62951361 2.126 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr17_-_87282771 2.030 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr4_+_123183456 1.698 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr9_-_58204310 1.663 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chrX_-_162159717 1.541 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr4_+_123183722 1.518 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr9_-_55048544 1.507 ENSMUST00000034854.6
 Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chr10_+_40883819 1.488 ENSMUST00000105509.1
 Wasf1
WAS protein family, member 1
chr7_-_110061319 1.343 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr5_+_77265454 1.328 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chrX_+_143664290 1.303 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_+_143664365 1.254 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr6_-_144209558 1.109 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0051028 mRNA transport(GO:0051028)
0.1 3.5 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.4 2.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.7 2.7 GO:0003360 brainstem development(GO:0003360)
0.3 2.6 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 2.6 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.8 2.5 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 2.5 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.2 2.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.7 GO:0045773 positive regulation of axon extension(GO:0045773)
0.5 1.5 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.4 1.5 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.0 1.5 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 1.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.3 1.3 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.2 1.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 1.0 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 1.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 1.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.9 2.7 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 2.6 GO:0031209 SCAR complex(GO:0031209)
0.3 1.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.4 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.1 0.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 3.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 3.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 2.8 GO:0070064 proline-rich region binding(GO:0070064)
0.5 2.7 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 2.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 2.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 2.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.5 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.5 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.2 1.4 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 1.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.0 GO:0005522 profilin binding(GO:0005522)
0.0 1.0 GO:0032183 SUMO binding(GO:0032183)
0.0 1.0 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.7 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.6 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)