Motif ID: Egr4

Z-value: 0.637


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_19018956 1.886 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
Meis1


Meis homeobox 1


chr11_-_19018714 1.556 ENSMUST00000177417.1
Meis1
Meis homeobox 1
chrX_+_36195968 1.555 ENSMUST00000115256.1
Zcchc12
zinc finger, CCHC domain containing 12
chr7_+_35119285 1.448 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr5_+_137288273 1.340 ENSMUST00000024099.4
ENSMUST00000085934.3
Ache

acetylcholinesterase

chr4_+_128883549 1.327 ENSMUST00000035667.8
Trim62
tripartite motif-containing 62
chr19_-_50678642 1.283 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chrX_+_36195938 1.267 ENSMUST00000048067.3
Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_36195950 1.258 ENSMUST00000115257.1
Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_36195904 1.247 ENSMUST00000115258.2
Zcchc12
zinc finger, CCHC domain containing 12
chr6_+_4747306 1.202 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
Peg10


paternally expressed 10


chr17_-_70851189 1.160 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr18_+_35829798 1.144 ENSMUST00000060722.6
Cxxc5
CXXC finger 5
chr13_+_48261427 1.050 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr12_+_17690793 1.045 ENSMUST00000071858.3
Hpcal1
hippocalcin-like 1
chr19_+_25505618 0.982 ENSMUST00000025755.4
Dmrt1
doublesex and mab-3 related transcription factor 1
chr19_-_5085483 0.965 ENSMUST00000140389.1
ENSMUST00000151413.1
ENSMUST00000077066.7
Tmem151a


transmembrane protein 151A


chr14_+_84443553 0.867 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chr18_+_86394952 0.810 ENSMUST00000058829.2
Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr14_+_56668242 0.807 ENSMUST00000116468.1
Mphosph8
M-phase phosphoprotein 8
chr2_-_102186322 0.779 ENSMUST00000111222.1
ENSMUST00000058790.5
Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr2_-_66634952 0.730 ENSMUST00000100064.2
ENSMUST00000100063.2
Scn9a

sodium channel, voltage-gated, type IX, alpha

chr11_-_86993682 0.715 ENSMUST00000018571.4
Ypel2
yippee-like 2 (Drosophila)
chr14_-_79481268 0.699 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr2_-_48949206 0.661 ENSMUST00000090976.3
ENSMUST00000149679.1
ENSMUST00000028098.4
Orc4


origin recognition complex, subunit 4


chr19_-_50678485 0.560 ENSMUST00000111756.3
Sorcs1
VPS10 domain receptor protein SORCS 1
chr9_+_65630552 0.520 ENSMUST00000055844.8
Rbpms2
RNA binding protein with multiple splicing 2
chr2_-_119477613 0.497 ENSMUST00000110808.1
ENSMUST00000049920.7
Ino80

INO80 homolog (S. cerevisiae)

chr9_-_95511897 0.469 ENSMUST00000079659.5
ENSMUST00000078374.6
U2surp

U2 snRNP-associated SURP domain containing

chr1_-_52500679 0.437 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr11_-_87987528 0.427 ENSMUST00000020775.2
Dynll2
dynein light chain LC8-type 2
chrX_-_20291728 0.404 ENSMUST00000115393.2
Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr9_+_108306205 0.398 ENSMUST00000007959.8
Rhoa
ras homolog gene family, member A
chr15_+_26309039 0.395 ENSMUST00000140840.1
ENSMUST00000152841.1
March11

membrane-associated ring finger (C3HC4) 11

chr13_-_111490111 0.390 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr3_+_135438722 0.376 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr4_+_130055010 0.364 ENSMUST00000123617.1
Col16a1
collagen, type XVI, alpha 1
chr13_-_111490028 0.358 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chr6_-_28261907 0.308 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
Zfp800



zinc finger protein 800



chr2_+_48949495 0.307 ENSMUST00000112745.1
Mbd5
methyl-CpG binding domain protein 5
chr2_+_91922178 0.297 ENSMUST00000170432.1
Chrm4
cholinergic receptor, muscarinic 4
chr14_+_79481164 0.296 ENSMUST00000040131.5
Elf1
E74-like factor 1
chr12_+_76370266 0.284 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chrX_-_153037549 0.278 ENSMUST00000051484.3
Mageh1
melanoma antigen, family H, 1
chr12_+_78226627 0.271 ENSMUST00000110388.2
ENSMUST00000052472.4
Gphn

gephyrin

chr9_-_59750616 0.261 ENSMUST00000163586.1
ENSMUST00000177963.1
ENSMUST00000051039.4
Senp8


SUMO/sentrin specific peptidase 8


chr4_+_86748526 0.243 ENSMUST00000082026.7
ENSMUST00000045512.8
Dennd4c

DENN/MADD domain containing 4C

chr16_+_64851991 0.240 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr8_-_92355764 0.233 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr6_-_4747019 0.225 ENSMUST00000126151.1
ENSMUST00000133306.1
ENSMUST00000123907.1
Sgce


sarcoglycan, epsilon


chr13_-_55513427 0.223 ENSMUST00000069929.6
ENSMUST00000069968.6
ENSMUST00000131306.1
ENSMUST00000046246.6
Pdlim7



PDZ and LIM domain 7



chr15_-_36608959 0.215 ENSMUST00000001809.8
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr6_-_4747157 0.214 ENSMUST00000090686.4
ENSMUST00000115579.1
ENSMUST00000115577.2
ENSMUST00000101677.3
ENSMUST00000004750.8
Sgce




sarcoglycan, epsilon




chr16_+_93832121 0.214 ENSMUST00000044068.6
Morc3
microrchidia 3
chr9_+_59750876 0.199 ENSMUST00000136740.1
ENSMUST00000135298.1
ENSMUST00000128341.1
Myo9a


myosin IXa


chr10_+_93160824 0.197 ENSMUST00000069965.7
Cdk17
cyclin-dependent kinase 17
chr14_-_33447142 0.195 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
Mapk8


mitogen-activated protein kinase 8


chr15_+_58141397 0.192 ENSMUST00000067563.7
Wdyhv1
WDYHV motif containing 1
chr1_+_135132693 0.190 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr11_-_51688614 0.189 ENSMUST00000007921.2
0610009B22Rik
RIKEN cDNA 0610009B22 gene
chr9_+_118926453 0.187 ENSMUST00000073109.5
Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chrX_-_20291776 0.170 ENSMUST00000072451.4
Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr17_-_31658729 0.169 ENSMUST00000166526.1
ENSMUST00000014684.4
U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr16_+_36071624 0.169 ENSMUST00000164916.1
ENSMUST00000163352.1
Ccdc58

coiled-coil domain containing 58

chr9_+_114688782 0.150 ENSMUST00000047404.6
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr17_+_69383024 0.149 ENSMUST00000112674.1
Zbtb14
zinc finger and BTB domain containing 14
chr19_-_21652779 0.143 ENSMUST00000179768.1
ENSMUST00000178523.1
ENSMUST00000038830.3
1110059E24Rik


RIKEN cDNA 1110059E24 gene


chr4_-_99120898 0.141 ENSMUST00000075836.5
Dock7
dedicator of cytokinesis 7
chr15_-_38078842 0.134 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr6_-_85961631 0.132 ENSMUST00000032071.9
Dusp11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chrX_-_145505175 0.125 ENSMUST00000143610.1
Amot
angiomotin
chr7_-_19404082 0.117 ENSMUST00000108458.3
Klc3
kinesin light chain 3
chr8_-_92356103 0.105 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr7_-_4778141 0.095 ENSMUST00000094892.5
Il11
interleukin 11
chr16_+_8830093 0.072 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr8_+_69088646 0.069 ENSMUST00000006435.7
Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr3_-_89089955 0.068 ENSMUST00000166687.1
Rusc1
RUN and SH3 domain containing 1
chr5_-_149051604 0.065 ENSMUST00000093196.4
Hmgb1
high mobility group box 1
chr4_+_127169131 0.063 ENSMUST00000046659.7
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chrX_-_12762069 0.056 ENSMUST00000096495.4
ENSMUST00000076016.5
Med14

mediator complex subunit 14

chr10_+_128232065 0.040 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
Timeless




timeless circadian clock 1




chr11_-_96777492 0.038 ENSMUST00000127375.1
ENSMUST00000021246.2
ENSMUST00000107661.3
Snx11


sorting nexin 11


chr5_-_96161742 0.038 ENSMUST00000129646.1
ENSMUST00000113005.2
ENSMUST00000154500.1
ENSMUST00000141383.1
Cnot6l



CCR4-NOT transcription complex, subunit 6-like



chr19_+_6306456 0.037 ENSMUST00000025681.7
Cdc42bpg
CDC42 binding protein kinase gamma (DMPK-like)
chrX_+_7762652 0.024 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
Tfe3



transcription factor E3



chr19_-_8786245 0.024 ENSMUST00000177216.1
Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr6_+_127149389 0.015 ENSMUST00000180811.1
9330179D12Rik
RIKEN cDNA 9330179D12 gene
chr2_-_9883993 0.014 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr9_+_48985358 0.009 ENSMUST00000047349.6
Usp28
ubiquitin specific peptidase 28
chr13_+_55445301 0.008 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6

G protein-coupled receptor kinase 6

chr19_-_8786272 0.007 ENSMUST00000176610.1
ENSMUST00000177056.1
Taf6l

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

chr11_-_86757483 0.004 ENSMUST00000060766.9
ENSMUST00000103186.4
Cltc

clathrin, heavy polypeptide (Hc)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.3 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.3 1.1 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.2 1.3 GO:0019695 choline metabolic process(GO:0019695)
0.2 1.4 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 3.4 GO:0035855 megakaryocyte development(GO:0035855)
0.1 1.0 GO:0060903 negative regulation of meiotic nuclear division(GO:0045835) positive regulation of meiosis I(GO:0060903)
0.1 0.4 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366)
0.1 0.3 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.9 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.1 0.6 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.3 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 1.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 0.3 GO:0051189 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.5 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.2 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.0 0.1 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.0 0.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.7 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.8 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.1 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.0 0.8 GO:2000463 receptor localization to synapse(GO:0097120) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.7 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 1.2 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.4 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.5 GO:0086010 membrane depolarization during action potential(GO:0086010)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.3 GO:0005605 basal lamina(GO:0005605)
0.0 6.2 GO:0016607 nuclear speck(GO:0016607)
0.0 0.5 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.6 GO:0030286 dynein complex(GO:0030286)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.2 5.3 GO:0032183 SUMO binding(GO:0032183)
0.1 1.4 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.6 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.4 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.7 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 3.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.1 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0050733 RS domain binding(GO:0050733)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)