Motif ID: Emx1_Emx2

Z-value: 0.644

Transcription factors associated with Emx1_Emx2:

Gene SymbolEntrez IDGene Name
Emx1 ENSMUSG00000033726.8 Emx1
Emx2 ENSMUSG00000043969.4 Emx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Emx1mm10_v2_chr6_+_85187438_85187510-0.424.4e-02Click!
Emx2mm10_v2_chr19_+_59458372_59458450-0.406.0e-02Click!


Activity profile for motif Emx1_Emx2.

activity profile for motif Emx1_Emx2


Sorted Z-values histogram for motif Emx1_Emx2

Sorted Z-values for motif Emx1_Emx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Emx1_Emx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_118961578 3.651 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr7_-_103827922 3.127 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr4_-_82505749 2.301 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505274 2.099 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr10_+_81257277 1.992 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr17_-_36032682 1.882 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr16_-_26371828 1.856 ENSMUST00000023154.2
 Cldn1
claudin 1
chr4_-_82505707 1.453 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chrX_+_8271133 1.199 ENSMUST00000127103.1
ENSMUST00000115591.1
 Slc38a5

solute carrier family 38, member 5

chr11_+_109543694 1.156 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr12_-_98577940 1.153 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr17_-_31636631 1.141 ENSMUST00000135425.1
ENSMUST00000151718.1
ENSMUST00000155814.1
 Cbs


cystathionine beta-synthase


chr8_-_21906412 1.137 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr10_+_90071095 1.111 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_160619971 1.105 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr3_-_49757257 1.101 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr3_+_121953213 1.070 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr7_-_142661858 1.063 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr13_-_97747373 1.017 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr2_-_93452679 0.894 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 3.0 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 2.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.6 1.9 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.3 1.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.2 GO:0015816 glycine transport(GO:0015816)
0.4 1.1 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.1 1.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 1.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 0.8 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 0.8 GO:0070295 renal water absorption(GO:0070295)
0.1 0.8 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.2 0.6 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.6 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 0.6 GO:0015862 uridine transport(GO:0015862)
0.1 0.6 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.8 3.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 2.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.0 GO:0070469 respiratory chain(GO:0070469)
0.1 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.2 0.6 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.2 3.7 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.8 3.1 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 2.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 1.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.2 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 1.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 1.1 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.8 GO:0015288 porin activity(GO:0015288)
0.0 0.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.7 GO:0016208 AMP binding(GO:0016208)
0.1 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)