Motif ID: En1

Z-value: 0.686


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_120602418-0.126.0e-01Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 4.393 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr14_+_67234620 3.956 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr1_+_6487231 3.282 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr16_-_26989974 2.875 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr15_-_56694525 2.256 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr19_+_47014672 2.234 ENSMUST00000037636.3
 Ina
internexin neuronal intermediate filament protein, alpha
chr12_+_109453455 2.007 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr1_-_158814469 1.835 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr6_+_4755327 1.829 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr1_+_72824482 1.770 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr11_-_77725281 1.470 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1
chr12_+_109452833 1.424 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr3_+_141465564 1.414 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr15_-_85581809 1.254 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr11_-_28583995 1.244 ENSMUST00000146385.2
 Ccdc85a
coiled-coil domain containing 85A
chr9_+_65587149 1.193 ENSMUST00000134538.1
ENSMUST00000136205.1
 Pif1

PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)

chr10_+_127514939 1.180 ENSMUST00000035735.9
 Ndufa4l2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr16_-_45953565 1.179 ENSMUST00000134802.1
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr9_+_65587187 1.174 ENSMUST00000047099.5
ENSMUST00000131483.1
ENSMUST00000141046.1
 Pif1


PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)


chr12_+_109540979 1.147 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
 Meg3


maternally expressed 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 4.0 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 3.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.5 3.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 2.9 GO:0006270 DNA replication initiation(GO:0006270)
0.3 2.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 2.4 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.6 2.3 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 2.0 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 1.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 1.8 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 1.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.2 1.5 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 1.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.4 1.3 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.0 1.3 GO:0060349 bone morphogenesis(GO:0060349)
0.1 1.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 1.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.0 GO:0001843 neural tube closure(GO:0001843) primary neural tube formation(GO:0014020) tube closure(GO:0060606)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0045180 basal cortex(GO:0045180)
0.0 2.4 GO:0005657 replication fork(GO:0005657)
0.2 2.2 GO:0005883 neurofilament(GO:0005883)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.1 1.3 GO:0000242 pericentriolar material(GO:0000242)
0.2 1.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.2 0.9 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.1 0.8 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.6 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 2.5 GO:0005042 netrin receptor activity(GO:0005042)
0.6 2.4 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.8 2.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.7 GO:0051015 actin filament binding(GO:0051015)
0.2 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.2 1.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 1.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.0 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 1.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 0.8 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.8 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)