Motif ID: En2
Z-value: 0.688
Transcription factors associated with En2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
En2 | ENSMUSG00000039095.7 | En2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
En2 | mm10_v2_chr5_+_28165690_28165717 | -0.68 | 3.5e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 3.9 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
0.7 | 5.9 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
0.5 | 3.3 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
0.4 | 1.1 | GO:0060023 | soft palate development(GO:0060023) |
0.3 | 1.4 | GO:0051866 | general adaptation syndrome(GO:0051866) |
0.3 | 0.9 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
0.2 | 3.9 | GO:0030953 | astral microtubule organization(GO:0030953) |
0.2 | 0.7 | GO:0030327 | prenylated protein catabolic process(GO:0030327) |
0.2 | 0.7 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
0.2 | 1.0 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.2 | 0.6 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
0.2 | 0.7 | GO:0061055 | myotome development(GO:0061055) |
0.2 | 0.5 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
0.2 | 0.7 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
0.2 | 0.5 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
0.2 | 3.0 | GO:0007530 | sex determination(GO:0007530) |
0.2 | 1.6 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.2 | 0.5 | GO:0045113 | regulation of integrin biosynthetic process(GO:0045113) |
0.2 | 2.8 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
0.2 | 1.2 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.1 | 1.3 | GO:0050957 | equilibrioception(GO:0050957) |
0.1 | 0.6 | GO:0032512 | regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
0.1 | 2.2 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
0.1 | 1.0 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474) |
0.1 | 0.5 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
0.1 | 3.5 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
0.1 | 0.3 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
0.1 | 0.4 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
0.1 | 1.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
0.1 | 1.1 | GO:0019985 | translesion synthesis(GO:0019985) |
0.1 | 0.7 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
0.1 | 1.9 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.1 | 0.2 | GO:0030300 | regulation of intestinal cholesterol absorption(GO:0030300) |
0.1 | 2.6 | GO:0007638 | mechanosensory behavior(GO:0007638) |
0.1 | 0.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.1 | 0.8 | GO:0031017 | exocrine pancreas development(GO:0031017) |
0.1 | 1.0 | GO:0099625 | regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) ventricular cardiac muscle cell membrane repolarization(GO:0099625) |
0.1 | 0.2 | GO:0071609 | negative regulation of interleukin-17 production(GO:0032700) neutrophil mediated killing of bacterium(GO:0070944) chemokine (C-C motif) ligand 5 production(GO:0071609) |
0.0 | 0.3 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
0.0 | 0.5 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.0 | 0.3 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
0.0 | 0.8 | GO:0045672 | positive regulation of osteoclast differentiation(GO:0045672) |
0.0 | 0.1 | GO:0002578 | negative regulation of antigen processing and presentation(GO:0002578) |
0.0 | 1.7 | GO:0035307 | positive regulation of protein dephosphorylation(GO:0035307) |
0.0 | 0.9 | GO:0009409 | response to cold(GO:0009409) |
0.0 | 0.5 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
0.0 | 0.3 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
0.0 | 0.2 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
0.0 | 0.1 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
0.0 | 0.2 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.0 | 0.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 0.7 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
0.0 | 0.7 | GO:0034508 | centromere complex assembly(GO:0034508) |
0.0 | 0.4 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.6 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 1.5 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
0.0 | 0.3 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.0 | 1.7 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
0.0 | 0.1 | GO:0097167 | circadian regulation of translation(GO:0097167) |
0.0 | 0.3 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
0.0 | 0.2 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
0.0 | 0.4 | GO:0000266 | mitochondrial fission(GO:0000266) |
0.0 | 0.7 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
0.0 | 0.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.0 | 0.3 | GO:0071384 | cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.8 | GO:0097149 | centralspindlin complex(GO:0097149) |
0.2 | 0.5 | GO:1990037 | Lewy body core(GO:1990037) |
0.2 | 2.3 | GO:0031045 | dense core granule(GO:0031045) |
0.1 | 1.0 | GO:0071437 | invadopodium(GO:0071437) |
0.1 | 1.6 | GO:0031527 | filopodium membrane(GO:0031527) |
0.1 | 1.1 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.1 | 0.7 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
0.1 | 1.0 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.1 | 1.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.1 | 1.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 0.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.5 | GO:0016272 | prefoldin complex(GO:0016272) |
0.0 | 1.0 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 0.6 | GO:0005640 | nuclear outer membrane(GO:0005640) |
0.0 | 2.2 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 1.3 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 3.9 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 0.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.0 | 0.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.0 | 0.2 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.0 | 0.1 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
0.0 | 0.4 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
0.0 | 0.1 | GO:1990357 | terminal web(GO:1990357) |
0.0 | 0.2 | GO:0005915 | zonula adherens(GO:0005915) |
0.0 | 0.7 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 0.4 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
0.0 | 0.7 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.9 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 0.3 | GO:0035371 | microtubule plus-end(GO:0035371) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 3.3 | GO:0048185 | activin binding(GO:0048185) |
0.3 | 1.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.2 | 1.0 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.2 | 0.5 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.1 | 1.0 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.1 | 0.4 | GO:0003681 | bent DNA binding(GO:0003681) |
0.1 | 0.7 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
0.1 | 0.8 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.1 | 0.6 | GO:0043495 | protein anchor(GO:0043495) |
0.1 | 0.7 | GO:0050692 | DBD domain binding(GO:0050692) |
0.1 | 2.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.3 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
0.1 | 3.0 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
0.1 | 0.4 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
0.1 | 1.2 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.1 | 0.7 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
0.0 | 1.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.0 | 0.3 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.0 | 0.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 0.2 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
0.0 | 0.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.0 | 0.5 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.3 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
0.0 | 1.5 | GO:0015485 | cholesterol binding(GO:0015485) |
0.0 | 2.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 1.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.0 | 0.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
0.0 | 0.5 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
0.0 | 0.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
0.0 | 0.2 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 0.2 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.0 | 1.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
0.0 | 3.2 | GO:0042393 | histone binding(GO:0042393) |
0.0 | 0.7 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 0.2 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.0 | 5.5 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
0.0 | 0.8 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
0.0 | 0.3 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
0.0 | 0.1 | GO:0039706 | co-receptor binding(GO:0039706) |
0.0 | 0.5 | GO:0001047 | core promoter binding(GO:0001047) |
0.0 | 0.1 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
0.0 | 1.6 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
0.0 | 1.0 | GO:0003682 | chromatin binding(GO:0003682) |