Motif ID: En2

Z-value: 0.688


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.683.5e-04Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 5.926 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr5_-_53707532 3.931 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr13_-_114458720 3.349 ENSMUST00000022287.5
 Fst
follistatin
chr6_+_8948608 3.077 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr6_+_4755327 2.722 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr12_+_109545390 2.513 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chrX_-_60893430 2.399 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr6_+_146888481 2.166 ENSMUST00000016631.7
ENSMUST00000111623.2
 Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr2_-_72986716 1.972 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr14_-_67715585 1.738 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr5_+_33658123 1.711 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr3_-_116253467 1.668 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr8_-_45382198 1.599 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr2_+_25372315 1.597 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr8_-_90908415 1.583 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chr16_-_42340595 1.569 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr6_-_50456085 1.545 ENSMUST00000146341.1
ENSMUST00000071728.4
 Osbpl3

oxysterol binding protein-like 3

chr3_+_134236483 1.530 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr4_+_109978004 1.499 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr1_+_110099295 1.449 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.3 3.9 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.2 3.9 GO:0030953 astral microtubule organization(GO:0030953)
0.1 3.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 3.3 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 3.0 GO:0007530 sex determination(GO:0007530)
0.2 2.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 2.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 2.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 1.7 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.0 1.7 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.2 1.6 GO:0016198 axon choice point recognition(GO:0016198)
0.1 1.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 1.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.3 1.4 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 1.3 GO:0050957 equilibrioception(GO:0050957)
0.2 1.2 GO:0005513 detection of calcium ion(GO:0005513)
0.4 1.1 GO:0060023 soft palate development(GO:0060023)
0.1 1.1 GO:0019985 translesion synthesis(GO:0019985)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0043195 terminal bouton(GO:0043195)
0.6 2.8 GO:0097149 centralspindlin complex(GO:0097149)
0.2 2.3 GO:0031045 dense core granule(GO:0031045)
0.0 2.2 GO:0005871 kinesin complex(GO:0005871)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.6 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.3 GO:0032420 stereocilium(GO:0032420)
0.1 1.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.0 GO:0071437 invadopodium(GO:0071437)
0.1 1.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.0 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.7 GO:0001772 immunological synapse(GO:0001772)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.1 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 0.5 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.3 3.3 GO:0048185 activin binding(GO:0048185)
0.0 3.2 GO:0042393 histone binding(GO:0042393)
0.1 3.0 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 2.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.3 1.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 1.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.5 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 1.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 1.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 1.0 GO:0003682 chromatin binding(GO:0003682)
0.0 0.9 GO:0008013 beta-catenin binding(GO:0008013)
0.1 0.8 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.8 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)