Motif ID: Esr1

Z-value: 1.031


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4710119_47101660.029.3e-01Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_9675163 1.706 ENSMUST00000100070.2
 Samd5
sterile alpha motif domain containing 5
chr2_+_122147680 1.466 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr5_-_77408034 1.192 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chr14_+_57999305 1.076 ENSMUST00000180534.1
 3110083C13Rik
RIKEN cDNA 3110083C13 gene
chr2_-_166155272 1.048 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr18_-_38211957 1.020 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr18_+_74442500 1.011 ENSMUST00000074157.6
 Myo5b
myosin VB
chr17_+_34629533 1.009 ENSMUST00000015620.6
 Prrt1
proline-rich transmembrane protein 1
chr18_+_74442551 0.979 ENSMUST00000121875.1
 Myo5b
myosin VB
chr4_-_141598206 0.953 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr5_-_77095225 0.951 ENSMUST00000120827.2
ENSMUST00000113453.2
 Hopx

HOP homeobox

chr11_+_101448403 0.945 ENSMUST00000010502.6
 Ifi35
interferon-induced protein 35
chr2_-_181043540 0.902 ENSMUST00000124400.1
 Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
chr13_+_31806627 0.872 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr1_-_184883218 0.864 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr4_+_95579463 0.845 ENSMUST00000150830.1
ENSMUST00000134012.2
 Fggy

FGGY carbohydrate kinase domain containing

chr12_+_109747903 0.818 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr16_+_17489639 0.813 ENSMUST00000023448.6
 Aifm3
apoptosis-inducing factor, mitochondrion-associated 3
chrX_-_135210672 0.784 ENSMUST00000033783.1
 Tceal6
transcription elongation factor A (SII)-like 6
chr1_-_87573825 0.766 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.0 GO:0032439 endosome localization(GO:0032439)
0.4 1.8 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 1.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.4 1.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 1.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 1.1 GO:0007338 single fertilization(GO:0007338)
0.3 1.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.0 GO:1904667 negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.1 1.0 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 1.0 GO:0071346 cellular response to interferon-gamma(GO:0071346)
0.3 0.9 GO:1903048 regulation of acetylcholine-gated cation channel activity(GO:1903048)
0.3 0.9 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.3 0.9 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.1 0.9 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 0.8 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.1 0.8 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 0.8 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.0 GO:0045179 apical cortex(GO:0045179)
0.2 1.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.3 GO:0061574 ASAP complex(GO:0061574)
0.0 1.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.1 0.9 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.8 GO:0031430 M band(GO:0031430)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.4 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 1.7 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.9 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.9 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 0.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.8 GO:0042556 cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 0.7 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.7 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.7 GO:0005542 folic acid binding(GO:0005542)