Motif ID: Esrrb_Esrra

Z-value: 1.419

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrrbmm10_v2_chr12_+_86361112_86361131-0.272.1e-01Click!
Esrramm10_v2_chr19_-_6921804_69218340.097.0e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 11.252 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr7_-_81706905 6.713 ENSMUST00000026922.7
 Homer2
homer homolog 2 (Drosophila)
chr1_-_84696182 6.560 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr7_-_74554474 5.546 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr4_+_13751297 5.479 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_+_7063423 5.356 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr2_+_121295437 5.304 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr10_+_128083273 5.118 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chrX_-_72656135 5.108 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chrX_-_141874870 4.988 ENSMUST00000182079.1
 Gm15294
predicted gene 15294
chr15_+_84669565 4.377 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr9_-_119578981 4.306 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr18_+_77185815 4.290 ENSMUST00000079618.4
 St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr17_+_43952999 4.171 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr12_-_111672290 4.111 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr7_-_98145472 4.107 ENSMUST00000098281.2
 Omp
olfactory marker protein
chr3_-_54915867 3.921 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr15_-_79804717 3.845 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr1_+_72824482 3.714 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr7_-_74554726 3.428 ENSMUST00000107453.1
 Slco3a1
solute carrier organic anion transporter family, member 3a1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.9 GO:0015732 prostaglandin transport(GO:0015732)
0.3 7.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.6 6.7 GO:0035584 calcium-mediated signaling using intracellular calcium source(GO:0035584)
0.6 6.6 GO:0007220 Notch receptor processing(GO:0007220)
0.2 6.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 6.2 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
2.0 5.9 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.3 5.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
1.8 5.5 GO:0086017 Purkinje myocyte action potential(GO:0086017)
0.4 5.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 5.3 GO:0045494 photoreceptor cell maintenance(GO:0045494)
1.3 5.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 4.6 GO:0032091 negative regulation of protein binding(GO:0032091)
0.5 4.5 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536)
0.1 4.5 GO:0014003 oligodendrocyte development(GO:0014003)
0.7 4.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4 4.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 4.2 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.7 4.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.8 4.0 GO:0090234 cellular response to testosterone stimulus(GO:0071394) regulation of kinetochore assembly(GO:0090234)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.9 GO:0070469 respiratory chain(GO:0070469)
0.1 9.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 9.2 GO:0009986 cell surface(GO:0009986)
0.5 8.9 GO:0045259 proton-transporting ATP synthase complex(GO:0045259)
0.0 8.6 GO:0043209 myelin sheath(GO:0043209)
1.7 8.3 GO:0032426 stereocilium tip(GO:0032426)
0.1 8.3 GO:0009925 basal plasma membrane(GO:0009925)
1.0 8.0 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 7.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 5.7 GO:0016363 nuclear matrix(GO:0016363)
0.3 5.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 5.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 4.9 GO:0005769 early endosome(GO:0005769)
0.1 4.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 4.5 GO:0043679 axon terminus(GO:0043679)
0.3 4.4 GO:0031932 TORC2 complex(GO:0031932)
0.6 4.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 4.0 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.3 3.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 3.7 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
2.4 9.7 GO:0004111 creatine kinase activity(GO:0004111)
0.4 9.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.3 9.0 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.4 7.0 GO:0004890 GABA-A receptor activity(GO:0004890)
1.7 6.7 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 6.6 GO:0005112 Notch binding(GO:0005112)
0.4 6.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 6.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 5.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.8 5.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 5.5 GO:0005518 collagen binding(GO:0005518)
0.9 5.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.9 5.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.6 4.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 4.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 4.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.7 4.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.7 4.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.7 4.0 GO:0033142 progesterone receptor binding(GO:0033142)