Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 0.758

Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:

Gene SymbolEntrez IDGene Name
Elk1 ENSMUSG00000009406.7 Elk1
Elk3 ENSMUSG00000008398.8 Elk3
Elk4 ENSMUSG00000026436.9 Elk4
Erf ENSMUSG00000040857.9 Erf
Etv3 ENSMUSG00000003382.12 Etv3
Fev ENSMUSG00000055197.4 Fev

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elk4mm10_v2_chr1_+_132007606_1320076340.754.3e-05Click!
Etv3mm10_v2_chr3_+_87525572_875256430.641.1e-03Click!
Elk1mm10_v2_chrX_-_20950597_209506130.539.6e-03Click!
Erfmm10_v2_chr7_-_25250720_252507610.125.9e-01Click!
Elk3mm10_v2_chr10_-_93311073_933111610.038.9e-01Click!


Activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3.

activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3


Sorted Z-values histogram for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3

Sorted Z-values for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_163602331 3.082 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr11_+_54522872 2.717 ENSMUST00000108895.1
ENSMUST00000101206.3
 Rapgef6

Rap guanine nucleotide exchange factor (GEF) 6

chr12_-_64965496 2.505 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr1_-_133025330 1.861 ENSMUST00000067429.3
ENSMUST00000067398.6
 Mdm4

transformed mouse 3T3 cell double minute 4

chr9_+_27299205 1.779 ENSMUST00000115247.1
ENSMUST00000133213.1
 Igsf9b

immunoglobulin superfamily, member 9B

chr18_-_84589491 1.774 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr19_-_28011138 1.770 ENSMUST00000174850.1
 Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr9_+_65908967 1.694 ENSMUST00000034949.3
ENSMUST00000154589.1
 Csnk1g1

casein kinase 1, gamma 1

chr11_-_48816936 1.623 ENSMUST00000140800.1
 Trim41
tripartite motif-containing 41
chr7_+_127876796 1.600 ENSMUST00000131000.1
 Zfp646
zinc finger protein 646
chr12_+_80644212 1.553 ENSMUST00000085245.5
 Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr9_-_44965519 1.502 ENSMUST00000125642.1
ENSMUST00000117506.1
ENSMUST00000117549.1
 Ube4a


ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)


chr5_+_111733924 1.496 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chrX_-_12762069 1.454 ENSMUST00000096495.4
ENSMUST00000076016.5
 Med14

mediator complex subunit 14

chr1_-_121327776 1.438 ENSMUST00000160688.1
 Insig2
insulin induced gene 2
chr6_+_86849488 1.424 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr16_-_87432597 1.403 ENSMUST00000039449.7
 Ltn1
listerin E3 ubiquitin protein ligase 1
chr11_-_104550392 1.402 ENSMUST00000106962.2
 Cdc27
cell division cycle 27
chr6_-_120364344 1.374 ENSMUST00000146667.1
 Ccdc77
coiled-coil domain containing 77
chr13_-_21531032 1.323 ENSMUST00000156674.2
ENSMUST00000110481.2
 Zkscan8

zinc finger with KRAB and SCAN domains 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 319 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 3.4 GO:0030033 microvillus assembly(GO:0030033)
0.0 3.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 2.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 2.4 GO:0003281 ventricular septum development(GO:0003281)
0.7 2.2 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 2.2 GO:0006829 zinc II ion transport(GO:0006829)
0.2 2.0 GO:0080009 mRNA methylation(GO:0080009)
0.6 1.9 GO:0051542 elastin biosynthetic process(GO:0051542)
0.1 1.9 GO:0003283 atrial septum development(GO:0003283)
0.1 1.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.6 1.8 GO:0019085 early viral transcription(GO:0019085)
0.4 1.8 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.2 1.8 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.1 1.8 GO:0030157 pancreatic juice secretion(GO:0030157)
0.6 1.7 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.1 1.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 1.7 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.3 1.6 GO:0021764 amygdala development(GO:0021764)
0.3 1.6 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 3.9 GO:0005802 trans-Golgi network(GO:0005802)
0.5 3.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 3.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 2.5 GO:1990745 EARP complex(GO:1990745)
0.0 2.5 GO:0030139 endocytic vesicle(GO:0030139)
0.2 2.1 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.3 2.0 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 1.9 GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 1.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 1.8 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 1.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 1.8 GO:0060077 inhibitory synapse(GO:0060077)
0.2 1.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 1.4 GO:0070847 core mediator complex(GO:0070847)
0.1 1.4 GO:0071439 clathrin complex(GO:0071439)
0.1 1.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 202 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.9 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 4.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 3.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 3.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 3.0 GO:0019905 syntaxin binding(GO:0019905)
0.1 2.7 GO:0051018 protein kinase A binding(GO:0051018)
0.0 2.5 GO:0003924 GTPase activity(GO:0003924)
0.4 2.2 GO:0071253 connexin binding(GO:0071253)
0.0 2.2 GO:0030276 clathrin binding(GO:0030276)
0.1 2.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 2.0 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.0 2.0 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.6 1.9 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.1 1.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.9 GO:0001067 regulatory region DNA binding(GO:0000975) regulatory region nucleic acid binding(GO:0001067) transcription regulatory region DNA binding(GO:0044212)
0.1 1.7 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1 1.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)