Motif ID: Ezh2_Atf2_Ikzf1
Z-value: 1.225
Transcription factors associated with Ezh2_Atf2_Ikzf1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Atf2 | ENSMUSG00000027104.12 | Atf2 |
| Ezh2 | ENSMUSG00000029687.10 | Ezh2 |
| Ikzf1 | ENSMUSG00000018654.11 | Ikzf1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Atf2 | mm10_v2_chr2_-_73892530_73892555 | 0.83 | 9.8e-07 | Click! |
| Ezh2 | mm10_v2_chr6_-_47594967_47595047 | 0.33 | 1.3e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 353 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 13.7 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.3 | 9.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 6.2 | GO:0032092 | positive regulation of protein binding(GO:0032092) |
| 0.2 | 5.5 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.3 | 4.1 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.1 | 4.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 1.2 | 3.7 | GO:0060067 | cervix development(GO:0060067) |
| 0.0 | 3.4 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 1.0 | 3.0 | GO:0007210 | serotonin receptor signaling pathway(GO:0007210) |
| 0.2 | 2.8 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.5 | 2.5 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.0 | 2.5 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.1 | 2.4 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.2 | 2.3 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.4 | 2.2 | GO:0003404 | optic vesicle morphogenesis(GO:0003404) |
| 0.4 | 2.1 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.1 | 2.0 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.0 | 2.0 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 0.0 | 1.7 | GO:0007628 | adult walking behavior(GO:0007628) walking behavior(GO:0090659) |
| 0.0 | 1.7 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 113 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 8.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 4.2 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.4 | 3.3 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.2 | 3.2 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 3.0 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 3.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.2 | 1.8 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 1.8 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 1.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 1.4 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 1.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.4 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 1.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 1.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.3 | 1.1 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 0.1 | 1.1 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 1.1 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 1.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 1.1 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 212 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 13.7 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 9.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 7.7 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 4.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.4 | 3.3 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.0 | 3.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.7 | 3.0 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.2 | 2.8 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.6 | 2.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.3 | 2.3 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.1 | 2.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 2.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 1.9 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 1.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.8 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 1.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.4 | 1.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 1.5 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.2 | 1.5 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 1.4 | GO:0045295 | gamma-catenin binding(GO:0045295) |
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