Motif ID: Foxa2_Foxa1

Z-value: 0.852

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa1mm10_v2_chr12_-_57546121_575461410.351.0e-01Click!
Foxa2mm10_v2_chr2_-_148046896_148046991-0.164.6e-01Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_84086379 3.146 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr17_+_29090969 2.438 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr9_+_74848437 2.156 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
 Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr6_+_8948608 2.120 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr6_+_14901344 1.977 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr14_+_13454010 1.897 ENSMUST00000112656.2
 Synpr
synaptoporin
chrX_+_169685191 1.660 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr14_-_48662740 1.643 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr7_+_113765998 1.535 ENSMUST00000046687.9
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr2_-_172940299 1.436 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr4_+_11191726 1.342 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr4_+_11191354 1.294 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr2_-_70825726 1.257 ENSMUST00000038584.8
 Tlk1
tousled-like kinase 1
chr1_-_138619687 1.257 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr12_+_38781093 1.218 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr3_+_5218546 1.214 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr6_+_34709610 1.139 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr18_-_47333311 1.128 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr7_+_113766119 1.126 ENSMUST00000084696.4
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr14_+_73237891 1.126 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.1 GO:0060023 soft palate development(GO:0060023)
0.1 2.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.2 2.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 2.4 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 2.2 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 1.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.7 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.4 1.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 1.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.5 1.4 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 1.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 1.3 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 1.2 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.1 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.1 1.1 GO:0033572 transferrin transport(GO:0033572)
0.1 1.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 1.0 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.2 1.0 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.0 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 1.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 2.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 2.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 2.2 GO:0030478 actin cap(GO:0030478)
0.2 1.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 1.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.2 1.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.8 GO:0001940 male pronucleus(GO:0001940)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.7 GO:0033269 internode region of axon(GO:0033269)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.4 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.4 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 2.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 2.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.3 1.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 1.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.0 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.0 GO:0005521 lamin binding(GO:0005521)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0046921 alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.2 0.6 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 0.6 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.6 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)