Motif ID: Foxb1

Z-value: 0.936


Transcription factors associated with Foxb1:

Gene SymbolEntrez IDGene Name
Foxb1 ENSMUSG00000059246.4 Foxb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxb1mm10_v2_chr9_-_69760924_697609400.223.0e-01Click!


Activity profile for motif Foxb1.

activity profile for motif Foxb1


Sorted Z-values histogram for motif Foxb1

Sorted Z-values for motif Foxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_26229707 4.034 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr3_+_55782500 3.733 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr17_+_93199348 2.939 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr6_+_8948608 2.840 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr1_-_158814469 2.828 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr18_-_47333311 2.560 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr3_+_134236483 2.514 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr6_+_14901344 2.296 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr2_+_55437100 2.264 ENSMUST00000112633.2
ENSMUST00000112632.1
 Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr13_+_5861489 2.200 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr8_+_58912257 2.074 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr10_+_37139558 2.069 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr3_-_123672321 2.050 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr19_+_47228804 1.958 ENSMUST00000111807.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr6_+_5390387 1.764 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr6_-_56362356 1.728 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr17_-_70851710 1.717 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr19_+_20601958 1.556 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr14_-_93888732 1.524 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr3_-_123690806 1.497 ENSMUST00000154668.1
 Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr10_-_96409038 1.403 ENSMUST00000179683.1
 Gm20091
predicted gene, 20091
chr2_+_30061754 1.380 ENSMUST00000149578.1
ENSMUST00000102866.3
 Set

SET nuclear oncogene

chr6_-_3494587 1.343 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr3_+_76075583 1.304 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr6_+_14901440 1.260 ENSMUST00000128567.1
 Foxp2
forkhead box P2
chr2_+_181767040 1.222 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr2_+_181767283 1.182 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr9_+_47530173 1.141 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chrX_+_106920618 1.100 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr2_-_163645125 1.051 ENSMUST00000017851.3
 Serinc3
serine incorporator 3
chr13_-_100616911 0.996 ENSMUST00000168772.1
ENSMUST00000163163.1
ENSMUST00000022137.7
 Marveld2


MARVEL (membrane-associating) domain containing 2


chr5_-_51567717 0.983 ENSMUST00000127135.1
ENSMUST00000151104.1
 Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

chr3_-_33082004 0.954 ENSMUST00000108225.3
 Pex5l
peroxisomal biogenesis factor 5-like
chr5_+_66676098 0.918 ENSMUST00000031131.9
 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr16_+_44394771 0.858 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr3_-_96240317 0.840 ENSMUST00000078756.5
 Hist2h2aa2
histone cluster 2, H2aa2
chr7_-_34655500 0.800 ENSMUST00000032709.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr19_+_5041337 0.794 ENSMUST00000116567.2
 Brms1
breast cancer metastasis-suppressor 1
chr3_+_96245530 0.781 ENSMUST00000074976.6
 Hist2h2aa1
histone cluster 2, H2aa1
chr3_-_95904683 0.769 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr3_-_127499095 0.704 ENSMUST00000182594.1
 Ank2
ankyrin 2, brain
chr18_-_43687695 0.694 ENSMUST00000082254.6
 Jakmip2
janus kinase and microtubule interacting protein 2
chr16_-_34095983 0.677 ENSMUST00000114973.1
ENSMUST00000114964.1
 Kalrn

kalirin, RhoGEF kinase

chr10_-_49783259 0.656 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr15_-_48791933 0.639 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
 Csmd3


CUB and Sushi multiple domains 3


chr17_+_34969912 0.610 ENSMUST00000173680.1
 Gm20481
predicted gene 20481
chr10_+_69925954 0.591 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr10_+_69925484 0.590 ENSMUST00000182692.1
ENSMUST00000092433.5
 Ank3

ankyrin 3, epithelial

chr2_+_130277157 0.572 ENSMUST00000028890.8
ENSMUST00000159373.1
 Nop56

NOP56 ribonucleoprotein

chr1_-_181211437 0.497 ENSMUST00000162963.1
ENSMUST00000162819.1
 Wdr26

WD repeat domain 26

chr7_+_67655414 0.492 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr10_+_69925766 0.472 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chrX_+_150594420 0.471 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr14_+_48120841 0.462 ENSMUST00000073150.4
 Peli2
pellino 2
chr2_-_65529275 0.461 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr1_+_19208914 0.422 ENSMUST00000027059.4
 Tfap2b
transcription factor AP-2 beta
chr3_+_136670076 0.412 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr5_-_137502402 0.403 ENSMUST00000111035.1
ENSMUST00000031728.4
 Pop7

processing of precursor 7, ribonuclease P family, (S. cerevisiae)

chr5_-_88527841 0.390 ENSMUST00000087033.3
 Igj
immunoglobulin joining chain
chrX_-_43274786 0.382 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr4_+_102430047 0.376 ENSMUST00000172616.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr10_-_61979073 0.341 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
 Col13a1


collagen, type XIII, alpha 1


chr4_-_139833524 0.335 ENSMUST00000030508.7
 Pax7
paired box gene 7
chrX_+_109095359 0.284 ENSMUST00000033598.8
 Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr2_-_147186389 0.282 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr10_+_69925800 0.236 ENSMUST00000182029.1
 Ank3
ankyrin 3, epithelial
chr4_-_139832920 0.225 ENSMUST00000174681.1
 Pax7
paired box gene 7
chr18_+_36952621 0.192 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr6_+_135065651 0.190 ENSMUST00000050104.7
 Gprc5a
G protein-coupled receptor, family C, group 5, member A
chr4_+_11191354 0.184 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr4_+_11191726 0.172 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr7_+_119900099 0.168 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr15_-_55548164 0.163 ENSMUST00000165356.1
 Mrpl13
mitochondrial ribosomal protein L13
chr2_-_176917518 0.160 ENSMUST00000108931.2
 Gm14296
predicted gene 14296
chr9_-_101198999 0.160 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr15_+_85116829 0.155 ENSMUST00000105085.1
 Gm10923
predicted gene 10923
chr1_-_156034826 0.154 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1

chrX_+_101376359 0.149 ENSMUST00000119080.1
 Gjb1
gap junction protein, beta 1
chr10_+_111506286 0.146 ENSMUST00000164773.1
 Phlda1
pleckstrin homology-like domain, family A, member 1
chr4_+_140701466 0.124 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr4_-_135494615 0.109 ENSMUST00000102549.3
 Nipal3
NIPA-like domain containing 3
chr1_+_45981548 0.089 ENSMUST00000085632.2
 Rpl23a-ps1
ribosomal protein 23A, pseudogene 1
chr5_-_87482258 0.086 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr14_+_34170640 0.066 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr9_-_67049143 0.066 ENSMUST00000113687.1
ENSMUST00000113693.1
ENSMUST00000113701.1
ENSMUST00000034928.5
ENSMUST00000113685.3
ENSMUST00000030185.4
ENSMUST00000050905.9
ENSMUST00000113705.1
ENSMUST00000113697.1
ENSMUST00000113707.2
 Tpm1









tropomyosin 1, alpha









chr11_-_17008647 0.055 ENSMUST00000102881.3
 Plek
pleckstrin
chr12_-_101958148 0.038 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
 Atxn3



ataxin 3



chr2_-_59948155 0.029 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr8_+_94037198 0.007 ENSMUST00000109556.2
ENSMUST00000093301.2
ENSMUST00000060632.7
 Ogfod1


2-oxoglutarate and iron-dependent oxygenase domain containing 1


chr1_+_10056922 0.004 ENSMUST00000149214.1
 Cspp1
centrosome and spindle pole associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.4 1.6 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.4 1.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.3 1.0 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.3 1.1 GO:0009597 detection of virus(GO:0009597)
0.3 3.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.2 0.9 GO:0007412 axon target recognition(GO:0007412)
0.2 2.4 GO:0060539 diaphragm development(GO:0060539)
0.2 2.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.2 1.8 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 1.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.4 GO:0097274 urea homeostasis(GO:0097274)
0.1 0.4 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 1.0 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.8 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 2.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.8 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 1.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.5 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.7 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 2.3 GO:0010107 potassium ion import(GO:0010107)
0.1 0.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.6 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 0.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 2.8 GO:0060349 bone morphogenesis(GO:0060349)
0.0 1.0 GO:0061028 establishment of endothelial barrier(GO:0061028)
0.0 0.4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 1.6 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.1 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.1 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.3 GO:0051297 centrosome organization(GO:0051297)
0.0 0.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 3.1 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.3 GO:0000154 rRNA modification(GO:0000154)
0.0 1.7 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 1.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.0 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.2 0.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.1 GO:0070852 cell body fiber(GO:0070852)
0.1 2.9 GO:0097440 apical dendrite(GO:0097440)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 3.0 GO:0030315 T-tubule(GO:0030315)
0.0 0.8 GO:0070822 Sin3-type complex(GO:0070822)
0.0 1.5 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.6 GO:0043195 terminal bouton(GO:0043195)
0.0 0.1 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.3 GO:0030496 midbody(GO:0030496)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 2.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 1.6 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 1.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 0.9 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.2 1.0 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 2.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 1.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 2.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.7 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 2.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.4 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 2.0 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)