Motif ID: Foxc1

Z-value: 0.822


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_31806650-0.125.9e-01Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_1010543 4.282 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr15_-_66948419 3.398 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr5_+_98854434 2.716 ENSMUST00000031278.4
 Bmp3
bone morphogenetic protein 3
chr13_-_54766553 2.411 ENSMUST00000036825.7
 Sncb
synuclein, beta
chr1_+_107511489 1.970 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr7_-_75308373 1.964 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr6_+_47244359 1.945 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr1_+_107511416 1.853 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_72824482 1.449 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_-_71653162 1.401 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr17_+_3397189 1.379 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr3_+_94377432 1.120 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr6_-_42324554 1.006 ENSMUST00000095974.3
 Fam131b
family with sequence similarity 131, member B
chr3_+_94377505 0.963 ENSMUST00000098877.2
 Rorc
RAR-related orphan receptor gamma
chr2_+_4976113 0.936 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chrX_-_102252154 0.935 ENSMUST00000050551.3
 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr16_-_21947536 0.903 ENSMUST00000023562.7
 Tmem41a
transmembrane protein 41a
chr6_-_42324640 0.870 ENSMUST00000031891.8
ENSMUST00000143278.1
 Fam131b

family with sequence similarity 131, member B

chr2_-_172370506 0.866 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr8_-_13494479 0.831 ENSMUST00000033828.5
 Gas6
growth arrest specific 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 3.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.3 3.4 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.1 2.7 GO:0042417 dopamine metabolic process(GO:0042417)
0.1 2.7 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.3 2.1 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 2.1 GO:0098792 xenophagy(GO:0098792)
0.0 2.0 GO:0006836 neurotransmitter transport(GO:0006836)
0.4 1.9 GO:0071205 clustering of voltage-gated potassium channels(GO:0045163) protein localization to juxtaparanode region of axon(GO:0071205)
0.0 1.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.4 1.5 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.5 1.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
0.1 1.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 1.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 0.9 GO:0007056 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.3 0.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) hematopoietic stem cell migration(GO:0035701) regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.3 0.8 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.2 0.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.8 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 3.4 GO:0016234 inclusion body(GO:0016234)
0.1 2.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.0 GO:0043195 terminal bouton(GO:0043195)
0.5 1.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 0.9 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 0.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.1 0.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.7 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.7 GO:0032420 stereocilium(GO:0032420)
0.1 0.6 GO:0005683 U7 snRNP(GO:0005683)
0.1 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 3.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 2.7 GO:0070700 BMP receptor binding(GO:0070700)
0.0 2.7 GO:0002020 protease binding(GO:0002020)
0.1 2.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 2.1 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.5 GO:0050693 LBD domain binding(GO:0050693)
0.2 1.4 GO:0045340 mercury ion binding(GO:0045340)
0.2 1.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.9 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 0.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 0.8 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.8 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 0.6 GO:0071209 U7 snRNA binding(GO:0071209)