Motif ID: Foxd3

Z-value: 0.677


Transcription factors associated with Foxd3:

Gene SymbolEntrez IDGene Name
Foxd3 ENSMUSG00000067261.3 Foxd3



Activity profile for motif Foxd3.

activity profile for motif Foxd3


Sorted Z-values histogram for motif Foxd3

Sorted Z-values for motif Foxd3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_6734827 3.659 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr17_+_29090969 3.403 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr17_+_93199348 3.086 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr5_+_148265202 2.380 ENSMUST00000110515.2
 Mtus2
microtubule associated tumor suppressor candidate 2
chr14_-_70630149 2.340 ENSMUST00000022694.9
 Dmtn
dematin actin binding protein
chr5_+_148265265 2.171 ENSMUST00000071878.5
 Mtus2
microtubule associated tumor suppressor candidate 2
chr5_+_148265307 2.102 ENSMUST00000110514.1
 Mtus2
microtubule associated tumor suppressor candidate 2
chr12_+_38783455 2.032 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr14_-_93888732 1.855 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr4_-_36056726 1.838 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr10_-_11080956 1.774 ENSMUST00000105560.1
 Grm1
glutamate receptor, metabotropic 1
chr12_+_38783503 1.718 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr3_+_102010138 1.662 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr6_-_144209471 1.462 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 1.413 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_3494587 1.379 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr1_-_126830632 1.378 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr16_+_13986596 1.319 ENSMUST00000056521.5
ENSMUST00000118412.1
ENSMUST00000131608.1
 2900011O08Rik


RIKEN cDNA 2900011O08 gene


chr1_-_126830786 1.228 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr8_-_87959560 1.101 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr11_+_98798653 1.100 ENSMUST00000037930.6
 Msl1
male-specific lethal 1 homolog (Drosophila)
chr2_-_172940299 1.019 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr3_+_76075583 0.924 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr2_+_181767040 0.860 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr12_+_111971545 0.803 ENSMUST00000079009.5
 Tdrd9
tudor domain containing 9
chr2_+_181767283 0.787 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chrX_-_163761323 0.762 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr5_-_88675190 0.718 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr15_+_100154379 0.574 ENSMUST00000023768.6
ENSMUST00000108971.2
 Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr17_+_28691419 0.535 ENSMUST00000124886.1
 Mapk14
mitogen-activated protein kinase 14
chr2_-_120539852 0.530 ENSMUST00000171215.1
 Zfp106
zinc finger protein 106
chr2_+_152669461 0.521 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
 H13



histocompatibility 13



chr5_-_120612558 0.435 ENSMUST00000140554.1
ENSMUST00000031599.2
ENSMUST00000177800.1
 1110008J03Rik


RIKEN cDNA 1110008J03 gene


chr2_+_9882622 0.401 ENSMUST00000114919.1
 4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr6_-_137571007 0.345 ENSMUST00000100841.2
 Eps8
epidermal growth factor receptor pathway substrate 8
chr10_-_19011948 0.311 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr6_+_77242715 0.311 ENSMUST00000161677.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242644 0.305 ENSMUST00000159616.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr1_+_134415414 0.299 ENSMUST00000112237.1
 Adipor1
adiponectin receptor 1
chr14_-_52213379 0.292 ENSMUST00000140603.1
 Chd8
chromodomain helicase DNA binding protein 8
chr10_-_127030813 0.287 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr11_+_83302817 0.242 ENSMUST00000142680.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr11_-_107189325 0.238 ENSMUST00000018577.7
ENSMUST00000106757.1
 Nol11

nucleolar protein 11

chr9_+_54980880 0.229 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr2_+_14388434 0.202 ENSMUST00000133258.1
 Slc39a12
solute carrier family 39 (zinc transporter), member 12
chr9_+_105642957 0.199 ENSMUST00000065778.6
 Pik3r4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr10_-_88605017 0.197 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chrX_+_164373363 0.186 ENSMUST00000033751.7
 Figf
c-fos induced growth factor
chr10_+_93488766 0.175 ENSMUST00000129421.1
 Hal
histidine ammonia lyase
chr16_-_16527364 0.174 ENSMUST00000069284.7
 Fgd4
FYVE, RhoGEF and PH domain containing 4
chr4_-_82850721 0.151 ENSMUST00000139401.1
 Zdhhc21
zinc finger, DHHC domain containing 21
chr4_+_115737754 0.138 ENSMUST00000106522.2
 Efcab14
EF-hand calcium binding domain 14
chr9_+_36832684 0.121 ENSMUST00000034630.8
 Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr10_-_127030789 0.111 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial

chr10_+_11609256 0.099 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr4_+_115737738 0.088 ENSMUST00000106525.2
 Efcab14
EF-hand calcium binding domain 14
chr10_+_42860776 0.079 ENSMUST00000105494.1
 Scml4
sex comb on midleg-like 4 (Drosophila)
chr15_+_92597104 0.051 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr7_+_67655414 0.051 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr4_+_108847827 0.007 ENSMUST00000102738.2
 Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.8 2.3 GO:1901731 calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731)
0.5 1.0 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.4 3.4 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.4 2.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 1.3 GO:0021814 cell motility involved in cerebral cortex radial glia guided migration(GO:0021814)
0.2 0.5 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 1.6 GO:0060539 diaphragm development(GO:0060539)
0.1 3.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 1.8 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.8 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.3 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 0.3 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.7 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 1.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.2 GO:0006547 histidine metabolic process(GO:0006547)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 2.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.3 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 0.2 GO:0030035 microspike assembly(GO:0030035)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 1.4 GO:0051297 centrosome organization(GO:0051297)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.6 2.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 1.8 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.2 1.1 GO:0072487 MSL complex(GO:0072487)
0.1 0.8 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.5 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 6.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.2 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 3.1 GO:0043195 terminal bouton(GO:0043195)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.9 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 2.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.4 GO:0030496 midbody(GO:0030496)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639)
0.2 3.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 3.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.0 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.5 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.3 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.5 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 2.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 1.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 6.7 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889) acetylcholine binding(GO:0042166)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 3.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.8 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)