Motif ID: Foxo3

Z-value: 1.146


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.906.4e-09Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 11.697 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr14_-_51913393 5.920 ENSMUST00000004673.7
ENSMUST00000111632.3
 Ndrg2

N-myc downstream regulated gene 2

chr16_-_22439719 4.642 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr10_+_112271123 4.546 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr11_+_3332426 4.349 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr7_-_103813913 4.273 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr6_+_55836878 3.883 ENSMUST00000044729.6
 Ccdc129
coiled-coil domain containing 129
chr16_-_43979050 3.856 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr7_+_141476374 3.284 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr4_-_87806296 2.794 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr4_-_87806276 2.759 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_-_116405986 2.715 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr11_-_101785252 2.665 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr5_+_65131184 2.517 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr2_-_51972990 2.425 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr5_+_66968559 2.381 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr5_+_66968416 2.335 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr10_+_40349265 2.142 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19

chr18_-_62756275 2.053 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr10_-_93310963 1.994 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 11.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.0 7.3 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.3 6.9 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.6 5.6 GO:0007379 segment specification(GO:0007379)
0.0 4.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.6 4.5 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.6 4.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.4 4.1 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.0 2.9 GO:0042060 wound healing(GO:0042060)
0.3 2.7 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.4 2.6 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.1 2.3 GO:0042182 ketone catabolic process(GO:0042182)
0.0 2.1 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.1 1.9 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.4 1.8 GO:1903726 negative regulation of phospholipid metabolic process(GO:1903726)
0.3 1.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.6 1.7 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.1 1.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.7 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.5 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 4.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.5 GO:0030673 axolemma(GO:0030673)
1.1 4.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 2.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.0 1.7 GO:0030139 endocytic vesicle(GO:0030139)
0.2 1.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.1 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.3 0.8 GO:0031251 PAN complex(GO:0031251)
0.1 0.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0005712 chiasma(GO:0005712)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 4.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.4 4.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.1 4.3 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.9 3.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 3.3 GO:0003823 antigen binding(GO:0003823)
0.0 2.7 GO:0019902 phosphatase binding(GO:0019902)
0.5 2.6 GO:0097001 ceramide binding(GO:0097001)
0.0 2.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 1.8 GO:0001851 complement component C3b binding(GO:0001851)
0.2 1.8 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)
0.5 1.5 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 1.5 GO:0030276 clathrin binding(GO:0030276)
0.0 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.2 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 1.2 GO:0005125 cytokine activity(GO:0005125)