Motif ID: Foxo4

Z-value: 0.788


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.602.5e-03Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103813913 3.256 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr17_+_78508063 1.792 ENSMUST00000024880.9
 Vit
vitrin
chr4_-_32950813 1.609 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr17_-_51831884 1.391 ENSMUST00000124222.1
 Satb1
special AT-rich sequence binding protein 1
chr5_-_70842617 1.366 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_-_175931051 1.357 ENSMUST00000108949.2
ENSMUST00000109018.2
 Gm8898

predicted gene 8898

chr2_-_175338197 1.251 ENSMUST00000121393.2
 Gm4631
predicted gene 4631
chr11_+_101246960 1.208 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr2_+_176521056 1.145 ENSMUST00000108997.2
ENSMUST00000178443.1
 Gm14431

predicted gene 14431

chr2_+_175469985 1.135 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
 Gm8923



predicted gene 8923



chr2_+_175372436 1.107 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
 Gm4723


predicted gene 4723


chr2_-_175703646 1.096 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
 Gm4245


predicted gene 4245


chr2_-_175141999 1.087 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
 Gm14399


predicted gene 14399


chr2_-_177957239 1.040 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
 Gm14326


predicted gene 14326


chr2_+_176670522 0.969 ENSMUST00000121956.1
ENSMUST00000108985.2
 Gm14306

predicted gene 14306

chr15_-_102625436 0.932 ENSMUST00000184485.1
ENSMUST00000185070.1
ENSMUST00000184616.1
ENSMUST00000108828.2
 ATF7



Cyclic AMP-dependent transcription factor ATF-7



chr2_+_178023284 0.831 ENSMUST00000108925.3
ENSMUST00000108926.2
 Etohi1

ethanol induced 1

chr15_-_97767798 0.822 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
 Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr2_-_177840318 0.779 ENSMUST00000108939.2
ENSMUST00000150650.1
 Gm14325

predicted gene 14325

chr7_-_4778141 0.749 ENSMUST00000094892.5
 Il11
interleukin 11
chr2_+_176226569 0.730 ENSMUST00000099009.2
ENSMUST00000136719.1
 2210418O10Rik

RIKEN cDNA 2210418O10 gene

chr18_-_38918642 0.711 ENSMUST00000040647.4
 Fgf1
fibroblast growth factor 1
chr2_-_75938407 0.703 ENSMUST00000099996.3
 Ttc30b
tetratricopeptide repeat domain 30B
chrX_-_134600976 0.703 ENSMUST00000033621.6
 Gla
galactosidase, alpha
chr4_-_6454262 0.697 ENSMUST00000029910.5
 Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chr8_+_79639618 0.684 ENSMUST00000173078.1
ENSMUST00000173286.1
 Otud4

OTU domain containing 4

chr15_-_102625061 0.682 ENSMUST00000184077.1
ENSMUST00000184906.1
ENSMUST00000169033.1
 ATF7


Cyclic AMP-dependent transcription factor ATF-7


chr2_+_175965331 0.662 ENSMUST00000109007.1
ENSMUST00000174416.1
 Gm2026

predicted gene 2026

chr9_-_119322421 0.635 ENSMUST00000040853.4
 Oxsr1
oxidative-stress responsive 1
chr2_-_176927809 0.634 ENSMUST00000099007.2
 Gm14296
predicted gene 14296
chr6_+_42286676 0.627 ENSMUST00000031894.6
 Clcn1
chloride channel 1
chr2_-_175206899 0.625 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
 Gm14391



predicted gene 14391



chr2_+_176798612 0.600 ENSMUST00000118012.2
 Gm14295
predicted gene 14295
chr4_+_97777606 0.596 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr2_+_177000956 0.549 ENSMUST00000108975.2
ENSMUST00000156844.1
 Gm14419

predicted gene 14419

chr14_+_32028989 0.548 ENSMUST00000022460.4
 Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr17_+_26202946 0.538 ENSMUST00000122058.1
ENSMUST00000025020.5
 Rgs11

regulator of G-protein signaling 11

chr2_+_176708328 0.527 ENSMUST00000108981.2
ENSMUST00000108980.2
 Gm14305

predicted gene 14305

chr2_-_176636318 0.522 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
 Gm14308


predicted gene 14308


chr14_-_25903100 0.517 ENSMUST00000052286.8
 Plac9a
placenta specific 9a
chr14_-_26182480 0.516 ENSMUST00000184142.1
 Plac9b
placenta specific 9b
chr11_-_77078404 0.509 ENSMUST00000102494.1
 Ccdc55
coiled-coil domain containing 55
chr2_-_175435782 0.501 ENSMUST00000152941.1
ENSMUST00000109045.2
 Gm4724

predicted gene 4724

chr8_+_26119361 0.488 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
 Rnf170



ring finger protein 170



chr2_-_176486773 0.475 ENSMUST00000120959.1
ENSMUST00000120521.1
 Gm14434

predicted gene 14434

chr8_-_47352348 0.459 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr15_-_102624922 0.447 ENSMUST00000183765.1
 ATF7
Cyclic AMP-dependent transcription factor ATF-7
chr2_-_177206421 0.444 ENSMUST00000108964.1
 Gm14410
predicted gene 14410
chr2_+_175869219 0.441 ENSMUST00000109011.1
 Gm6710
predicted gene 6710
chr19_-_5796924 0.439 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr12_-_69892989 0.437 ENSMUST00000110567.1
ENSMUST00000171211.1
 Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr12_+_75308308 0.411 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr8_-_45410539 0.385 ENSMUST00000034056.4
ENSMUST00000167106.1
 Tlr3

toll-like receptor 3

chr11_-_42182924 0.383 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr2_-_178078425 0.382 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
 Zfp931


zinc finger protein 931


chr6_+_42286709 0.372 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chrX_+_85574018 0.366 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
 Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr3_+_107895916 0.357 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr8_+_70234613 0.346 ENSMUST00000145078.1
 Sugp2
SURP and G patch domain containing 2
chr7_-_89517576 0.340 ENSMUST00000041761.5
 Prss23
protease, serine, 23
chr2_-_45110336 0.335 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr9_+_57076395 0.325 ENSMUST00000168177.1
 Sin3a
transcriptional regulator, SIN3A (yeast)
chr6_+_56714891 0.297 ENSMUST00000031805.8
 Avl9
AVL9 homolog (S. cerevisiase)
chr9_+_57076343 0.290 ENSMUST00000168678.1
 Sin3a
transcriptional regulator, SIN3A (yeast)
chr4_+_45972233 0.269 ENSMUST00000102929.1
 Tdrd7
tudor domain containing 7
chr18_-_6490808 0.252 ENSMUST00000028100.6
ENSMUST00000050542.5
 Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr6_-_128424883 0.250 ENSMUST00000001559.8
 Itfg2
integrin alpha FG-GAP repeat containing 2
chr5_-_90366176 0.245 ENSMUST00000014421.8
ENSMUST00000081914.6
ENSMUST00000168058.2
 Ankrd17


ankyrin repeat domain 17


chr7_-_4524229 0.202 ENSMUST00000154913.1
 Tnni3
troponin I, cardiac 3
chr14_-_32085595 0.186 ENSMUST00000022461.4
ENSMUST00000067955.5
ENSMUST00000124303.1
ENSMUST00000112000.1
 Dph3



diphthamine biosynthesis 3



chr2_-_144011202 0.184 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr11_-_102579461 0.156 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr1_+_171213969 0.137 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
 Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr6_+_95117740 0.116 ENSMUST00000032107.7
ENSMUST00000119582.1
 Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr11_-_85139939 0.098 ENSMUST00000108075.2
 Usp32
ubiquitin specific peptidase 32
chr10_-_83337440 0.087 ENSMUST00000126617.1
 Slc41a2
solute carrier family 41, member 2
chr12_+_69893105 0.080 ENSMUST00000021466.8
 Atl1
atlastin GTPase 1
chr1_-_168431695 0.079 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr8_-_33843562 0.064 ENSMUST00000183062.1
 Rbpms
RNA binding protein gene with multiple splicing
chr8_+_26119611 0.064 ENSMUST00000140819.1
 Rnf170
ring finger protein 170
chr7_-_139582790 0.057 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr17_-_23745829 0.046 ENSMUST00000046525.8
 Kremen2
kringle containing transmembrane protein 2
chr8_-_105943382 0.035 ENSMUST00000038896.7
 Lcat
lecithin cholesterol acyltransferase
chr11_-_102365111 0.035 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr10_-_40257648 0.032 ENSMUST00000019982.7
 Gtf3c6
general transcription factor IIIC, polypeptide 6, alpha
chr5_-_24445254 0.024 ENSMUST00000030800.6
 Fastk
Fas-activated serine/threonine kinase
chr17_+_80944611 0.013 ENSMUST00000025092.4
 Tmem178
transmembrane protein 178
chr14_-_70153811 0.011 ENSMUST00000035612.5
 Ccar2
cell cycle activator and apoptosis regulator 2
chr5_-_24445166 0.002 ENSMUST00000115043.1
ENSMUST00000115041.1
 Fastk

Fas-activated serine/threonine kinase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 0.6 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.2 0.8 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.2 0.6 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.4 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 1.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.7 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 1.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.1 1.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.3 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.4 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.2 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.0 0.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.6 GO:0060074 synapse maturation(GO:0060074)
0.0 0.7 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 0.8 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0005861 troponin complex(GO:0005861)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.5 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.4 GO:0005720 nuclear heterochromatin(GO:0005720)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 0.7 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 0.7 GO:0016936 galactoside binding(GO:0016936)
0.1 0.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.2 GO:0030172 troponin C binding(GO:0030172)
0.1 1.2 GO:0015026 coreceptor activity(GO:0015026)
0.1 1.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.7 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 1.8 GO:0005539 glycosaminoglycan binding(GO:0005539)