Motif ID: Foxp2_Foxp3

Z-value: 0.635

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp2mm10_v2_chr6_+_14901440_149014970.321.4e-01Click!
Foxp3mm10_v2_chrX_+_7579666_7579693-0.068.0e-01Click!


Activity profile for motif Foxp2_Foxp3.

activity profile for motif Foxp2_Foxp3


Sorted Z-values histogram for motif Foxp2_Foxp3

Sorted Z-values for motif Foxp2_Foxp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 3.972 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 3.280 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 2.848 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr8_+_66386292 2.565 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr6_+_141524379 2.438 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr3_+_5218516 2.231 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr3_+_5218589 2.034 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr3_+_5218546 2.014 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr16_-_22439719 1.959 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr18_+_5593566 1.895 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr7_+_141476374 1.804 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr18_+_69344503 1.637 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr1_-_128592284 1.595 ENSMUST00000052172.6
ENSMUST00000142893.1
 Cxcr4

chemokine (C-X-C motif) receptor 4

chr3_-_52104891 1.594 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr4_-_87806296 1.593 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr6_+_30541582 1.511 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr1_-_190170178 1.497 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr11_+_3332426 1.472 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr1_-_170110491 1.437 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr10_-_92162753 1.417 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 10.1 GO:0042572 retinol metabolic process(GO:0042572)
0.6 3.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 2.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 2.6 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 2.6 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 2.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 2.2 GO:0007379 segment specification(GO:0007379)
0.2 2.2 GO:0042118 endothelial cell activation(GO:0042118)
0.2 2.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.3 2.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 2.0 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 1.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.5 1.6 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.5 1.5 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 1.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 1.4 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.0 1.4 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.3 1.3 GO:0055099 regulation of Cdc42 protein signal transduction(GO:0032489) response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.1 1.3 GO:0070842 aggresome assembly(GO:0070842)
0.3 1.2 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 1.6 GO:0030478 actin cap(GO:0030478)
0.1 1.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.9 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.9 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.2 0.8 GO:0044307 dendritic branch(GO:0044307)
0.1 0.8 GO:0001940 male pronucleus(GO:0001940)
0.1 0.8 GO:0033391 chromatoid body(GO:0033391)
0.0 0.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 10.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.6 2.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.5 2.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.7 2.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 2.1 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.9 GO:0030507 spectrin binding(GO:0030507)
0.0 1.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.8 GO:0003823 antigen binding(GO:0003823)
0.0 1.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.5 1.6 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.5 GO:0050681 androgen receptor binding(GO:0050681)
0.2 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 1.3 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.2 1.3 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.2 GO:0008430 selenium binding(GO:0008430)
0.1 1.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)