Motif ID: Gata2_Gata1
Z-value: 0.544
Transcription factors associated with Gata2_Gata1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Gata1 | ENSMUSG00000031162.8 | Gata1 |
Gata2 | ENSMUSG00000015053.8 | Gata2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Gata2 | mm10_v2_chr6_+_88198656_88198675 | 0.69 | 2.6e-04 | Click! |
Gata1 | mm10_v2_chrX_-_7967817_7967910 | 0.02 | 9.3e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 3.0 | GO:0001955 | blood vessel maturation(GO:0001955) |
0.4 | 1.9 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504) |
0.4 | 2.2 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
0.3 | 1.0 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913) |
0.3 | 1.3 | GO:0010593 | negative regulation of lamellipodium assembly(GO:0010593) |
0.3 | 3.2 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.3 | 0.8 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
0.2 | 1.4 | GO:0002317 | plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
0.2 | 1.1 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) |
0.2 | 0.5 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
0.1 | 0.4 | GO:0003100 | regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
0.1 | 1.0 | GO:0015862 | uridine transport(GO:0015862) |
0.1 | 0.7 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) |
0.1 | 1.3 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
0.1 | 1.3 | GO:0009404 | toxin metabolic process(GO:0009404) |
0.1 | 0.8 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
0.1 | 0.3 | GO:0015920 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
0.1 | 0.3 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
0.1 | 0.5 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
0.1 | 0.6 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
0.1 | 0.2 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
0.1 | 0.6 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
0.1 | 0.5 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
0.1 | 0.6 | GO:1901162 | tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586) serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
0.1 | 0.5 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.1 | 0.4 | GO:0032911 | nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911) |
0.1 | 0.4 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
0.1 | 0.8 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.1 | 0.3 | GO:0071476 | cellular hypotonic response(GO:0071476) |
0.1 | 0.8 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.1 | 0.2 | GO:0030300 | regulation of intestinal cholesterol absorption(GO:0030300) |
0.1 | 0.3 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.1 | 0.3 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
0.1 | 0.8 | GO:0021860 | pyramidal neuron development(GO:0021860) |
0.1 | 0.2 | GO:0030299 | intestinal cholesterol absorption(GO:0030299) |
0.0 | 0.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
0.0 | 1.2 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
0.0 | 0.1 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
0.0 | 0.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.0 | 1.0 | GO:0035855 | megakaryocyte development(GO:0035855) |
0.0 | 0.2 | GO:0030091 | protein repair(GO:0030091) |
0.0 | 0.6 | GO:0046697 | decidualization(GO:0046697) |
0.0 | 0.1 | GO:0071455 | cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455) |
0.0 | 0.5 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
0.0 | 0.1 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
0.0 | 1.1 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
0.0 | 0.2 | GO:0019532 | oxalate transport(GO:0019532) |
0.0 | 0.1 | GO:0000019 | regulation of mitotic recombination(GO:0000019) |
0.0 | 0.1 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
0.0 | 0.2 | GO:0071635 | negative regulation of transforming growth factor beta production(GO:0071635) |
0.0 | 0.1 | GO:0033762 | response to glucagon(GO:0033762) |
0.0 | 0.3 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
0.0 | 0.3 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
0.0 | 0.3 | GO:0045332 | phospholipid translocation(GO:0045332) |
0.0 | 3.1 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.2 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
0.0 | 0.1 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
0.0 | 0.1 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
0.0 | 0.2 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.0 | 0.1 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.0 | 1.5 | GO:0030168 | platelet activation(GO:0030168) |
0.0 | 0.6 | GO:0051642 | centrosome localization(GO:0051642) |
0.0 | 0.1 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
0.0 | 0.5 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
0.0 | 0.8 | GO:0021766 | hippocampus development(GO:0021766) |
0.0 | 0.0 | GO:0035811 | negative regulation of urine volume(GO:0035811) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.2 | GO:0005861 | troponin complex(GO:0005861) |
0.2 | 1.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.2 | 3.1 | GO:0005614 | interstitial matrix(GO:0005614) |
0.2 | 0.6 | GO:0043512 | inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512) |
0.2 | 0.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
0.2 | 0.8 | GO:0097441 | basilar dendrite(GO:0097441) |
0.1 | 1.3 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.1 | 1.3 | GO:0097449 | astrocyte projection(GO:0097449) |
0.0 | 0.7 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
0.0 | 0.2 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
0.0 | 0.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.0 | 0.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.0 | 0.1 | GO:0071438 | NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438) |
0.0 | 1.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.0 | 0.2 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.0 | 0.1 | GO:0099738 | basal cortex(GO:0045180) cell cortex region(GO:0099738) |
0.0 | 0.1 | GO:1990393 | 3M complex(GO:1990393) |
0.0 | 0.4 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
0.0 | 0.1 | GO:0030870 | Mre11 complex(GO:0030870) |
0.0 | 0.3 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 0.3 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 0.2 | GO:0098533 | ATPase dependent transmembrane transport complex(GO:0098533) |
0.0 | 0.1 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 0.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 0.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.0 | 0.2 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.1 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.2 | GO:0030172 | troponin C binding(GO:0030172) |
0.3 | 0.8 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
0.3 | 1.3 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.2 | 0.2 | GO:0070051 | fibrinogen binding(GO:0070051) |
0.2 | 0.6 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.2 | 0.7 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
0.2 | 0.5 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
0.2 | 0.9 | GO:0016936 | galactoside binding(GO:0016936) |
0.1 | 0.4 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) arginine binding(GO:0034618) |
0.1 | 1.3 | GO:0051022 | Rho GDP-dissociation inhibitor binding(GO:0051022) |
0.1 | 1.2 | GO:0019865 | immunoglobulin binding(GO:0019865) |
0.1 | 0.7 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
0.1 | 2.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.1 | 3.2 | GO:0001968 | fibronectin binding(GO:0001968) |
0.1 | 3.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.1 | 0.3 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
0.1 | 1.1 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 0.6 | GO:0034711 | inhibin binding(GO:0034711) |
0.1 | 0.5 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
0.1 | 0.2 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
0.1 | 0.8 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.1 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.8 | GO:0016594 | glycine binding(GO:0016594) |
0.0 | 0.3 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
0.0 | 1.0 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
0.0 | 0.2 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
0.0 | 1.0 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
0.0 | 0.3 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.0 | 0.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.0 | 0.3 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.0 | 0.1 | GO:0030171 | hydrogen ion channel activity(GO:0015252) voltage-gated proton channel activity(GO:0030171) |
0.0 | 0.1 | GO:0004942 | anaphylatoxin receptor activity(GO:0004942) |
0.0 | 1.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.0 | 0.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.0 | 1.0 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.1 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
0.0 | 0.3 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
0.0 | 0.2 | GO:0019531 | bicarbonate transmembrane transporter activity(GO:0015106) oxalate transmembrane transporter activity(GO:0019531) |
0.0 | 0.2 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
0.0 | 0.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 0.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.0 | 0.5 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 1.1 | GO:0035591 | signaling adaptor activity(GO:0035591) |
0.0 | 0.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.0 | 0.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.0 | 0.0 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
0.0 | 0.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.2 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
0.0 | 0.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.2 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |