Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.470

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx1mm10_v2_chr5_-_24527276_245272760.311.6e-01Click!
Alx3mm10_v2_chr3_+_107595031_107595164-0.096.8e-01Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 7.437 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr12_+_38780817 2.778 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr12_+_38780284 2.658 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr6_+_8948608 2.132 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr12_+_109545390 1.831 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr12_+_38781093 1.685 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr10_+_73821857 1.653 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
 Pcdh15



















protocadherin 15



















chr3_+_55782500 1.569 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_147264124 1.280 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr6_-_23248264 1.223 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_-_40037387 1.165 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr3_+_125404072 1.146 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_134236483 1.123 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr2_+_109917639 1.099 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr1_-_190170671 1.042 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr3_+_125404292 1.013 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_159839729 1.008 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr12_+_38783503 0.956 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_38783455 0.951 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr1_+_109983737 0.928 ENSMUST00000172005.1
 Cdh7
cadherin 7, type 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.9 7.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 1.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 1.7 GO:0050957 equilibrioception(GO:0050957)
0.5 1.4 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 1.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 1.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 1.3 GO:0043129 surfactant homeostasis(GO:0043129)
0.4 1.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 1.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.0 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.1 1.0 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 0.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.2 0.6 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.0 0.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.5 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.5 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0032420 stereocilium(GO:0032420)
0.0 1.0 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.1 0.5 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.4 GO:0071437 invadopodium(GO:0071437)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 7.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.3 2.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 1.4 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.8 GO:0043495 protein anchor(GO:0043495)
0.1 0.8 GO:0048185 activin binding(GO:0048185)
0.2 0.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.7 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.6 GO:0016208 AMP binding(GO:0016208)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0034056 estrogen response element binding(GO:0034056)