Motif ID: Gbx2

Z-value: 0.570


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_89933290-0.737.7e-05Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_117781017 3.619 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr3_-_116129615 2.571 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr13_-_97747373 2.283 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 2.068 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_22439719 1.971 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr4_+_118961578 1.755 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr14_-_30353468 1.723 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr16_-_36784924 1.682 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr16_-_36784784 1.410 ENSMUST00000165531.1
 Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr5_-_111761697 0.924 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr17_-_36032682 0.917 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chrM_-_14060 0.785 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr16_-_26371828 0.755 ENSMUST00000023154.2
 Cldn1
claudin 1
chr2_-_160619971 0.732 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr4_+_110397661 0.712 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr4_+_110397764 0.706 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr13_+_31806627 0.703 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr8_-_21906412 0.661 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr14_-_18893376 0.568 ENSMUST00000151926.1
 Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr9_+_96258697 0.558 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr3_-_113577743 0.426 ENSMUST00000067980.5
 Amy1
amylase 1, salivary
chr13_+_23763660 0.413 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chr12_-_98259416 0.395 ENSMUST00000021390.7
 Galc
galactosylceramidase
chr11_-_103267405 0.387 ENSMUST00000021324.2
 Map3k14
mitogen-activated protein kinase kinase kinase 14
chr2_+_152754156 0.374 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr12_+_111814170 0.374 ENSMUST00000021714.7
 Zfyve21
zinc finger, FYVE domain containing 21
chr5_-_31295862 0.322 ENSMUST00000041266.7
ENSMUST00000172435.1
 Fndc4

fibronectin type III domain containing 4

chr11_-_79504078 0.291 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr5_+_113735782 0.274 ENSMUST00000065698.5
 Ficd
FIC domain containing
chr1_-_155417394 0.263 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr11_-_45955183 0.226 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr3_+_88615367 0.210 ENSMUST00000176539.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr13_+_49544443 0.204 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr15_+_103240405 0.195 ENSMUST00000036004.9
ENSMUST00000087351.7
 Hnrnpa1

heterogeneous nuclear ribonucleoprotein A1

chr1_+_24005505 0.195 ENSMUST00000181961.1
 Gm26524
predicted gene, 26524
chr18_+_56432116 0.176 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr8_-_41041828 0.154 ENSMUST00000051379.7
 Mtus1
mitochondrial tumor suppressor 1
chr4_+_32657107 0.148 ENSMUST00000071642.4
ENSMUST00000178134.1
 Mdn1

midasin homolog (yeast)

chr19_-_59170978 0.101 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr14_-_66213552 0.093 ENSMUST00000178730.1
 Ptk2b
PTK2 protein tyrosine kinase 2 beta
chr2_+_27079371 0.059 ENSMUST00000091233.6
 Adamtsl2
ADAMTS-like 2
chr5_-_115341142 0.053 ENSMUST00000139167.1
 Gatc
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)
chr11_+_59306920 0.028 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr1_-_175625580 0.021 ENSMUST00000027810.7
 Fh1
fumarate hydratase 1
chr1_+_180109192 0.020 ENSMUST00000143176.1
ENSMUST00000135056.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chrM_+_14138 0.016 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr18_-_67245818 0.002 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.8 3.1 GO:0042938 dipeptide transport(GO:0042938)
0.6 1.7 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.4 2.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 1.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 0.9 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 0.7 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.2 2.6 GO:0061032 chorio-allantoic fusion(GO:0060710) visceral serous pericardium development(GO:0061032)
0.1 0.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.4 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.3 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.2 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.1 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.0 1.8 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.2 GO:0071225 cellular response to muramyl dipeptide(GO:0071225)
0.0 0.3 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 0.2 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 1.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.6 GO:0002102 podosome(GO:0002102)
0.1 0.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.0 0.8 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.6 2.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.6 3.1 GO:0042895 antibiotic transporter activity(GO:0042895)
0.6 1.8 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.3 1.7 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 0.4 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.6 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 1.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.7 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.3 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)