Motif ID: Gli1

Z-value: 0.886


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.649.3e-04Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 182 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 2.496 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr2_-_54085542 2.494 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr13_-_114458720 2.341 ENSMUST00000022287.5
 Fst
follistatin
chrX_-_60893430 2.132 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr11_+_80300866 2.013 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr11_-_119547744 1.952 ENSMUST00000026670.4
 Nptx1
neuronal pentraxin 1
chr15_-_85581809 1.757 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr2_+_118111876 1.621 ENSMUST00000039559.8
 Thbs1
thrombospondin 1
chr2_+_20737306 1.608 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr1_+_72824482 1.553 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr10_-_64090265 1.516 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr15_-_95528228 1.416 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr10_-_64090241 1.412 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr12_+_44328882 1.278 ENSMUST00000020939.8
ENSMUST00000110748.2
 Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr15_-_95528702 1.275 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr6_-_52012476 1.274 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr4_-_58553553 1.232 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr4_-_58553311 1.175 ENSMUST00000107571.1
ENSMUST00000055018.4
 Lpar1

lysophosphatidic acid receptor 1

chr4_-_68954351 1.092 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr18_-_43373248 1.090 ENSMUST00000118043.1
 Dpysl3
dihydropyrimidinase-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 2.9 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.2 2.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 2.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 2.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 2.5 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.4 GO:1902017 regulation of cilium assembly(GO:1902017)
0.3 2.3 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.7 2.2 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1 2.1 GO:0007530 sex determination(GO:0007530)
0.7 2.0 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.6 1.8 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.2 1.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 1.6 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 1.6 GO:0048706 embryonic skeletal system development(GO:0048706)
0.2 1.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 1.3 GO:0002757 immune response-activating signal transduction(GO:0002757)
0.2 1.1 GO:0007296 vitellogenesis(GO:0007296)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0030139 endocytic vesicle(GO:0030139)
0.2 3.1 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 3.1 GO:0043204 perikaryon(GO:0043204)
0.1 3.0 GO:0043194 axon initial segment(GO:0043194)
0.0 2.2 GO:0060170 ciliary membrane(GO:0060170)
0.5 1.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.3 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 3.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.7 GO:0005080 protein kinase C binding(GO:0005080)
0.8 2.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 2.3 GO:0048185 activin binding(GO:0048185)
0.1 2.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 1.8 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.5 1.6 GO:0070052 collagen V binding(GO:0070052)
0.2 1.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 1.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 1.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 1.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 1.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.0 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.0 GO:0015085 calcium channel activity(GO:0005262) calcium ion transmembrane transporter activity(GO:0015085)
0.1 0.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)