Motif ID: Gli2

Z-value: 1.044


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053339_119053370-0.096.7e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 8.289 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_56694525 7.109 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chrX_-_141725181 5.979 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr12_+_58211772 4.488 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr6_-_72789240 4.250 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_137314394 4.140 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr12_+_38780284 3.741 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr6_-_72788952 3.716 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr4_+_36952930 2.928 ENSMUST00000144029.1
 Gm12371
predicted gene 12371
chr7_-_4752972 2.927 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chrX_-_9662950 2.332 ENSMUST00000033519.2
 Dynlt3
dynein light chain Tctex-type 3
chr9_-_43239816 2.283 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr13_+_5861489 2.257 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr8_+_127064022 2.246 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr8_+_127064107 2.229 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr18_+_86394952 2.106 ENSMUST00000058829.2
 Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr10_-_114801364 1.975 ENSMUST00000061632.7
 Trhde
TRH-degrading enzyme
chr1_+_167001417 1.941 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr15_-_85581809 1.939 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr8_+_127063893 1.832 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 8.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.7 8.0 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.8 7.1 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.1 6.3 GO:0003383 apical constriction(GO:0003383)
0.0 5.4 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.2 4.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 4.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 3.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.4 2.5 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.1 2.3 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 2.1 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 2.0 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 2.0 GO:0043171 peptide catabolic process(GO:0043171)
0.6 1.9 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.2 1.9 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 1.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.7 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.4 1.4 GO:0009957 epidermal cell fate specification(GO:0009957)
0.4 1.4 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.2 1.4 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0005667 transcription factor complex(GO:0005667)
0.8 6.3 GO:0033269 internode region of axon(GO:0033269)
0.2 5.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 3.1 GO:0097470 ribbon synapse(GO:0097470)
0.2 2.9 GO:0030061 mitochondrial crista(GO:0030061)
0.3 2.3 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 1.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.3 1.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 1.4 GO:0090537 CERF complex(GO:0090537)
0.0 1.3 GO:0033270 paranode region of axon(GO:0033270)
0.1 1.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.1 GO:0032281 voltage-gated calcium channel complex(GO:0005891) AMPA glutamate receptor complex(GO:0032281)
0.2 1.0 GO:0070876 SOSS complex(GO:0070876)
0.0 0.9 GO:0005643 nuclear pore(GO:0005643)
0.2 0.8 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.2 0.7 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 8.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 8.0 GO:0008013 beta-catenin binding(GO:0008013)
0.1 6.5 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
1.9 5.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.5 4.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 3.4 GO:0003774 motor activity(GO:0003774)
0.1 2.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 2.3 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 2.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.3 2.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 2.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.6 1.9 GO:0097100 supercoiled DNA binding(GO:0097100)
0.5 1.9 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.3 1.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.5 1.4 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) hedgehog family protein binding(GO:0097108)
0.1 1.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.4 1.1 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)