Motif ID: Gli3_Zic1

Z-value: 0.799

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic1mm10_v2_chr9_-_91365778_913658150.511.3e-02Click!
Gli3mm10_v2_chr13_+_15463202_15463240-0.164.6e-01Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 2.363 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr9_-_54661870 2.017 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr10_-_127341583 1.957 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr6_-_101377342 1.924 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr1_+_195017399 1.840 ENSMUST00000181273.1
 A330023F24Rik
RIKEN cDNA A330023F24 gene
chr8_-_105966038 1.840 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr6_-_101377897 1.803 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chrX_-_167382747 1.699 ENSMUST00000026839.4
 Prps2
phosphoribosyl pyrophosphate synthetase 2
chr7_-_142657466 1.569 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr9_-_54661666 1.559 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr6_+_17463749 1.407 ENSMUST00000115443.1
 Met
met proto-oncogene
chr14_-_55560340 1.379 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr7_+_5056706 1.331 ENSMUST00000144802.1
 Ccdc106
coiled-coil domain containing 106
chrX_-_16911774 1.310 ENSMUST00000040134.7
 Ndp
Norrie disease (pseudoglioma) (human)
chr2_-_155945282 1.285 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5
chr4_+_144893077 1.252 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_-_36104060 1.232 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr7_+_35119285 1.232 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr2_+_70562007 1.215 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr6_+_125494419 1.214 ENSMUST00000181266.1
 Gm26728
predicted gene, 26728

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 3.4 GO:0007528 neuromuscular junction development(GO:0007528)
0.3 2.6 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 2.5 GO:0048663 neuron fate commitment(GO:0048663)
0.5 2.0 GO:0060032 notochord regression(GO:0060032)
0.6 1.9 GO:1904685 positive regulation of metalloendopeptidase activity(GO:1904685)
0.5 1.9 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.3 1.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 1.6 GO:0036233 glycine import(GO:0036233)
0.2 1.6 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.3 1.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.2 1.3 GO:0030913 paranodal junction assembly(GO:0030913)
0.2 1.3 GO:2001053 regulation of mesenchymal cell apoptotic process(GO:2001053) negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1 1.3 GO:0042572 retinol metabolic process(GO:0042572)
0.2 1.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 1.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.2 1.2 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 1.2 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 1.2 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.0 GO:0045178 basal part of cell(GO:0045178)
0.0 2.8 GO:0043235 receptor complex(GO:0043235)
0.2 2.0 GO:0097542 ciliary tip(GO:0097542)
0.1 2.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 1.7 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.4 1.2 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.4 1.2 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.4 1.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 1.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 1.1 GO:0016324 apical plasma membrane(GO:0016324)
0.1 1.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.3 0.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.9 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 3.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.7 2.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 2.0 GO:0036122 BMP binding(GO:0036122)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 1.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 1.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 1.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 1.8 GO:0071837 HMG box domain binding(GO:0071837)
0.4 1.7 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 1.7 GO:0015026 coreceptor activity(GO:0015026)
0.3 1.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.4 GO:0005125 cytokine activity(GO:0005125)
0.2 1.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 1.1 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 1.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 1.0 GO:2001069 glycogen binding(GO:2001069)