Motif ID: Glis2

Z-value: 1.206


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_4594735-0.311.5e-01Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 11.597 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr7_-_103843154 4.365 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr12_+_109544498 4.357 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr8_-_87472576 4.040 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr1_-_84696182 4.011 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr3_-_89322883 3.567 ENSMUST00000029673.5
 Efna3
ephrin A3
chr8_+_58912257 3.472 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr8_+_58911755 3.277 ENSMUST00000062978.6
 BC030500
cDNA sequence BC030500
chr6_-_48840988 3.079 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr5_+_136083916 2.992 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr6_+_48841633 2.970 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr6_+_48841476 2.954 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr2_-_26294550 2.942 ENSMUST00000057224.3
 4932418E24Rik
RIKEN cDNA 4932418E24 gene
chr2_-_54085542 2.814 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr5_+_136084022 2.784 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr13_-_56296551 2.772 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr2_-_57124003 2.744 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr4_+_104367549 2.726 ENSMUST00000106830.2
 Dab1
disabled 1
chr2_-_57113053 2.606 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr2_+_174330006 2.492 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
 Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.3 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.9 12.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 6.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 5.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
1.3 5.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.9 4.4 GO:0015671 oxygen transport(GO:0015671)
0.4 4.0 GO:0007220 Notch receptor processing(GO:0007220)
0.3 4.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.6 3.6 GO:0032796 uropod organization(GO:0032796)
0.1 3.6 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.9 2.8 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.3 2.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.9 2.7 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 2.7 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040) negative regulation of protein folding(GO:1903333)
0.5 2.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.8 2.4 GO:0010752 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752) negative regulation of plasminogen activation(GO:0010757)
0.8 2.3 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.1 2.3 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.5 2.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.4 2.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 5.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.5 4.4 GO:0005833 hemoglobin complex(GO:0005833)
0.0 4.1 GO:0005769 early endosome(GO:0005769)
0.1 3.6 GO:0001891 phagocytic cup(GO:0001891)
0.4 2.9 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 2.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.7 GO:0016235 aggresome(GO:0016235)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.8 2.4 GO:0005577 fibrinogen complex(GO:0005577)
0.2 2.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.8 2.3 GO:0044194 cytolytic granule(GO:0044194)
0.0 2.3 GO:0009986 cell surface(GO:0009986)
0.1 2.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.1 GO:0005882 intermediate filament(GO:0005882)
0.0 2.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 1.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 1.5 GO:0090537 CERF complex(GO:0090537)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.6 GO:0019841 retinol binding(GO:0019841)
0.0 6.1 GO:0005096 GTPase activator activity(GO:0005096)
0.2 5.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 5.0 GO:0005112 Notch binding(GO:0005112)
1.1 4.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.4 3.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 3.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 3.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.5 2.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.8 GO:0008009 chemokine activity(GO:0008009)
0.9 2.7 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.4 2.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.8 2.4 GO:0070052 collagen V binding(GO:0070052)
0.6 2.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.1 2.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.2 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.4 2.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 2.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)