Motif ID: Glis3

Z-value: 0.591


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_286801220.019.8e-01Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 2.357 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 2.076 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 1.981 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_17463749 1.021 ENSMUST00000115443.1
 Met
met proto-oncogene
chr6_+_17463927 0.709 ENSMUST00000115442.1
 Met
met proto-oncogene
chr6_+_17463826 0.649 ENSMUST00000140070.1
 Met
met proto-oncogene
chr7_+_45017953 0.616 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr4_+_118428078 0.611 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
 Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr7_-_142657466 0.584 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr14_+_54640952 0.565 ENSMUST00000169818.2
 Gm17606
predicted gene, 17606
chr13_-_29984219 0.521 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr10_-_105574435 0.519 ENSMUST00000061506.8
 Tmtc2
transmembrane and tetratricopeptide repeat containing 2
chr14_+_62292475 0.511 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chrX_-_94123359 0.510 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
 Zfx


zinc finger protein X-linked


chr7_-_142899985 0.503 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chrX_-_23365044 0.500 ENSMUST00000115313.1
 Klhl13
kelch-like 13
chr7_+_126781483 0.473 ENSMUST00000172352.1
ENSMUST00000094037.4
 Tbx6

T-box 6

chr11_-_69801716 0.468 ENSMUST00000011285.4
ENSMUST00000102585.1
 Fgf11

fibroblast growth factor 11

chr17_-_23745829 0.440 ENSMUST00000046525.8
 Kremen2
kringle containing transmembrane protein 2
chrX_-_94123087 0.425 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.4 GO:0042572 retinol metabolic process(GO:0042572)
0.3 2.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.9 GO:0060746 parental behavior(GO:0060746)
0.1 0.7 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.1 0.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.6 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.5 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 0.5 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.4 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.1 0.4 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.1 0.4 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.4 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.3 GO:0060613 fat pad development(GO:0060613)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.6 2.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.6 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.5 GO:0035240 dopamine binding(GO:0035240)
0.1 0.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.3 GO:0045545 syndecan binding(GO:0045545)
0.0 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.2 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.2 GO:0005534 galactose binding(GO:0005534)