Motif ID: Gsc2_Dmbx1

Z-value: 0.626

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.462.6e-02Click!


Activity profile for motif Gsc2_Dmbx1.

activity profile for motif Gsc2_Dmbx1


Sorted Z-values histogram for motif Gsc2_Dmbx1

Sorted Z-values for motif Gsc2_Dmbx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 91 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_18818895 5.807 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr5_+_3343893 4.908 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr5_+_3344194 4.763 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chr2_-_104257400 2.928 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr14_-_118052235 2.078 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr8_-_113848615 1.677 ENSMUST00000093113.4
 Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr2_+_91259822 1.625 ENSMUST00000138470.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr3_-_103737995 1.495 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr19_+_8617991 1.479 ENSMUST00000010250.2
 Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr14_+_99298652 1.401 ENSMUST00000005279.6
 Klf5
Kruppel-like factor 5
chr13_-_97747373 1.327 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_168431502 1.295 ENSMUST00000064438.4
 Pbx1
pre B cell leukemia homeobox 1
chr13_-_97747399 1.259 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_+_177444653 1.253 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr7_-_25398697 1.182 ENSMUST00000105177.2
ENSMUST00000149349.1
 Lipe

lipase, hormone sensitive

chr12_+_81631369 1.112 ENSMUST00000036116.5
 Ttc9
tetratricopeptide repeat domain 9
chr7_-_80403315 1.110 ENSMUST00000147150.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr15_-_74734313 1.094 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr13_+_3361029 1.083 ENSMUST00000179981.1
 Gm16505
predicted gene 16505
chr11_-_52282564 1.056 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 9.7 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 5.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 3.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.0 2.9 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.3 2.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 1.7 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 1.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 1.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.3 GO:0021766 hippocampus development(GO:0021766)
0.4 1.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 1.1 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 1.1 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 1.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 1.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 0.9 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 0.9 GO:0036089 cleavage furrow formation(GO:0036089)
0.2 0.8 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.2 0.7 GO:1904049 regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.8 GO:0005901 caveola(GO:0005901)
0.1 2.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 0.7 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0042581 specific granule(GO:0042581)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 GO:0030332 cyclin binding(GO:0030332)
0.0 4.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 2.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 1.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 1.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.8 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.8 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.3 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)