Motif ID: Gsc2_Dmbx1

Z-value: 0.626

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.462.6e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_18818895 5.807 ENSMUST00000166873.2
Cdh10
cadherin 10
chr5_+_3343893 4.908 ENSMUST00000165117.1
Cdk6
cyclin-dependent kinase 6
chr5_+_3344194 4.763 ENSMUST00000042410.4
Cdk6
cyclin-dependent kinase 6
chr2_-_104257400 2.928 ENSMUST00000141159.1
D430041D05Rik
RIKEN cDNA D430041D05 gene
chr14_-_118052235 2.078 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr8_-_113848615 1.677 ENSMUST00000093113.4
Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr2_+_91259822 1.625 ENSMUST00000138470.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr3_-_103737995 1.495 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chr19_+_8617991 1.479 ENSMUST00000010250.2
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr14_+_99298652 1.401 ENSMUST00000005279.6
Klf5
Kruppel-like factor 5
chr13_-_97747373 1.327 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_168431502 1.295 ENSMUST00000064438.4
Pbx1
pre B cell leukemia homeobox 1
chr13_-_97747399 1.259 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_+_177444653 1.253 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr7_-_25398697 1.182 ENSMUST00000105177.2
ENSMUST00000149349.1
Lipe

lipase, hormone sensitive

chr12_+_81631369 1.112 ENSMUST00000036116.5
Ttc9
tetratricopeptide repeat domain 9
chr7_-_80403315 1.110 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr15_-_74734313 1.094 ENSMUST00000023260.3
Lypd2
Ly6/Plaur domain containing 2
chr13_+_3361029 1.083 ENSMUST00000179981.1
Gm16505
predicted gene 16505
chr11_-_52282564 1.056 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr1_-_168431695 1.054 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chr11_+_78322965 0.981 ENSMUST00000017534.8
Aldoc
aldolase C, fructose-bisphosphate
chr1_-_168431896 0.954 ENSMUST00000176540.1
Pbx1
pre B cell leukemia homeobox 1
chr1_-_155232710 0.896 ENSMUST00000035914.3
BC034090
cDNA sequence BC034090
chr13_-_113618549 0.895 ENSMUST00000109241.3
Snx18
sorting nexin 18
chr11_+_19924403 0.872 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr14_-_31640878 0.751 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr6_+_4902913 0.675 ENSMUST00000175889.1
ENSMUST00000168998.2
Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr1_+_12692430 0.617 ENSMUST00000180062.1
ENSMUST00000177608.1
Sulf1

sulfatase 1

chr7_-_15879844 0.593 ENSMUST00000172758.1
ENSMUST00000044434.6
Crx

cone-rod homeobox containing gene

chr2_-_51972990 0.539 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr4_+_102589687 0.524 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr11_+_70459940 0.510 ENSMUST00000147289.1
ENSMUST00000126105.1
Zmynd15

zinc finger, MYND-type containing 15

chr9_-_60838200 0.496 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr7_-_127725616 0.486 ENSMUST00000076091.2
Ctf2
cardiotrophin 2
chr11_+_19924354 0.485 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chr6_-_59426279 0.418 ENSMUST00000051065.4
Gprin3
GPRIN family member 3
chrX_+_134295225 0.406 ENSMUST00000037687.7
Tmem35
transmembrane protein 35
chr7_+_101969796 0.391 ENSMUST00000084852.5
Numa1
nuclear mitotic apparatus protein 1
chr5_-_134456702 0.389 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr2_-_51973219 0.387 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr2_-_24049389 0.376 ENSMUST00000051416.5
Hnmt
histamine N-methyltransferase
chr13_+_75089826 0.370 ENSMUST00000022075.4
Pcsk1
proprotein convertase subtilisin/kexin type 1
chr4_+_84884418 0.345 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr11_-_70459957 0.327 ENSMUST00000019064.2
Cxcl16
chemokine (C-X-C motif) ligand 16
chr19_+_26605106 0.307 ENSMUST00000025862.7
ENSMUST00000176030.1
Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr2_+_91265252 0.299 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr10_-_22149270 0.284 ENSMUST00000179054.1
ENSMUST00000069372.6
E030030I06Rik

RIKEN cDNA E030030I06 gene

chr11_+_4186789 0.274 ENSMUST00000041042.6
ENSMUST00000180088.1
Tbc1d10a

TBC1 domain family, member 10a

chr11_+_5099406 0.259 ENSMUST00000134267.1
ENSMUST00000036320.5
ENSMUST00000150632.1
Rhbdd3


rhomboid domain containing 3


chr10_+_80292453 0.256 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chr8_-_60954726 0.237 ENSMUST00000110302.1
Clcn3
chloride channel 3
chr4_+_154960915 0.236 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr6_+_136954521 0.236 ENSMUST00000137768.1
Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr5_+_19907502 0.226 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr2_+_102659213 0.216 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr9_-_50617228 0.206 ENSMUST00000147671.1
ENSMUST00000145139.1
ENSMUST00000155435.1
AU019823


expressed sequence AU019823


chr19_-_53371766 0.206 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chrM_+_8600 0.204 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr11_+_5099608 0.200 ENSMUST00000139742.1
Rhbdd3
rhomboid domain containing 3
chrX_+_74424632 0.196 ENSMUST00000114129.2
ENSMUST00000132749.1
Ikbkg

inhibitor of kappaB kinase gamma

chr7_-_98656530 0.183 ENSMUST00000038359.4
2210018M11Rik
RIKEN cDNA 2210018M11 gene
chr11_-_107337556 0.177 ENSMUST00000040380.6
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr17_-_35164891 0.170 ENSMUST00000025253.5
Prrc2a
proline-rich coiled-coil 2A
chrX_+_134585644 0.169 ENSMUST00000113211.1
Rpl36a
ribosomal protein L36A
chr11_+_95010277 0.169 ENSMUST00000124735.1
Samd14
sterile alpha motif domain containing 14
chr10_+_18407658 0.164 ENSMUST00000037341.7
Nhsl1
NHS-like 1
chrX_+_7728439 0.157 ENSMUST00000033489.7
Praf2
PRA1 domain family 2
chr10_-_9901079 0.151 ENSMUST00000141722.1
Stxbp5
syntaxin binding protein 5 (tomosyn)
chr11_-_68973840 0.139 ENSMUST00000038644.4
Rangrf
RAN guanine nucleotide release factor
chr11_-_5099084 0.139 ENSMUST00000063232.6
Ewsr1
Ewing sarcoma breakpoint region 1
chr8_+_78509319 0.132 ENSMUST00000034111.8
Slc10a7
solute carrier family 10 (sodium/bile acid cotransporter family), member 7
chrX_+_169879596 0.110 ENSMUST00000112105.1
ENSMUST00000078947.5
Mid1

midline 1

chr11_-_59187738 0.110 ENSMUST00000170895.2
Guk1
guanylate kinase 1
chr16_-_4213404 0.102 ENSMUST00000023165.6
Crebbp
CREB binding protein
chr1_-_44218952 0.090 ENSMUST00000054801.3
Mettl21e
methyltransferase like 21E
chrX_+_74424534 0.087 ENSMUST00000135165.1
ENSMUST00000114128.1
ENSMUST00000114133.2
ENSMUST00000004330.3
Ikbkg



inhibitor of kappaB kinase gamma



chrX_+_48623737 0.086 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_+_178187417 0.078 ENSMUST00000161075.1
ENSMUST00000027783.7
Desi2

desumoylating isopeptidase 2

chr8_+_19682268 0.064 ENSMUST00000153710.1
ENSMUST00000127799.1
Gm6483

predicted gene 6483

chrX_+_38600626 0.062 ENSMUST00000000365.2
Mcts1
malignant T cell amplified sequence 1
chr10_+_128225830 0.056 ENSMUST00000026455.7
Mip
major intrinsic protein of eye lens fiber
chr10_+_90576872 0.048 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr5_-_144223516 0.045 ENSMUST00000085701.6
Tecpr1
tectonin beta-propeller repeat containing 1
chr11_-_90687572 0.043 ENSMUST00000107869.2
ENSMUST00000154599.1
ENSMUST00000107868.1
ENSMUST00000020849.2
Tom1l1



target of myb1-like 1 (chicken)



chr11_+_98026695 0.034 ENSMUST00000092425.4
Rpl19
ribosomal protein L19
chr9_+_50617516 0.034 ENSMUST00000141366.1
Pih1d2
PIH1 domain containing 2
chr19_-_47919269 0.018 ENSMUST00000095998.5
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr4_-_133968611 0.017 ENSMUST00000102552.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr19_+_46056539 0.013 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr5_-_96161990 0.001 ENSMUST00000155901.1
Cnot6l
CCR4-NOT transcription complex, subunit 6-like

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.4 1.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.3 2.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 0.9 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.7 GO:1904049 regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 1.1 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2 1.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.2 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 0.8 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 1.1 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 1.7 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 0.9 GO:0036089 cleavage furrow formation(GO:0036089)
0.1 3.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 1.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 1.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.2 GO:0048388 endosomal lumen acidification(GO:0048388) synaptic vesicle lumen acidification(GO:0097401)
0.1 0.4 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.5 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 5.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0009182 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066) GDP metabolic process(GO:0046710)
0.0 0.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.2 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.3 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.4 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 2.9 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 1.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 1.3 GO:0021766 hippocampus development(GO:0021766)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.0 0.1 GO:2000010 positive regulation of protein localization to cell surface(GO:2000010)
0.0 0.4 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.7 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 2.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.8 GO:0005901 caveola(GO:0005901)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0042581 specific granule(GO:0042581)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0030136 clathrin-coated vesicle(GO:0030136)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.7 GO:0030332 cyclin binding(GO:0030332)
0.2 1.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.2 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 1.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.3 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.8 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 1.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.8 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0 4.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)