Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.552

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx1mm10_v2_chr10_-_103028771_1030287820.272.1e-01Click!
Gsx1mm10_v2_chr5_+_147188678_1471886960.242.8e-01Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_49757257 5.751 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr5_-_62766153 4.609 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_62419668 3.221 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr1_-_190170671 2.980 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr18_+_57468478 2.951 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr2_+_116067213 2.896 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr15_-_8710734 2.778 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 1.978 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_62765618 1.899 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_23411490 1.837 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr11_-_98053415 1.814 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr13_+_44121167 1.759 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr5_-_84417359 1.713 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr1_-_163725123 1.696 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr15_-_11037968 1.687 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr2_-_116067391 1.491 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr5_+_17574726 1.444 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_-_66296807 1.422 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chr1_-_72284248 1.409 ENSMUST00000097698.4
ENSMUST00000027381.6
 Pecr

peroxisomal trans-2-enoyl-CoA reductase

chr15_+_55307743 1.138 ENSMUST00000023053.5
ENSMUST00000110221.2
ENSMUST00000110217.3
 Col14a1


collagen, type XIV, alpha 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.2 4.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.5 3.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.2 3.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.0 3.0 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.6 1.8 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 1.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 1.7 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.2 1.6 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 1.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 1.4 GO:0060178 regulation of exocyst localization(GO:0060178)
0.1 1.4 GO:0030497 fatty acid elongation(GO:0030497)
0.4 1.3 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 1.1 GO:0061050 regulation of cell growth involved in cardiac muscle cell development(GO:0061050)
0.3 1.0 GO:0050975 sensory perception of touch(GO:0050975)
0.1 1.0 GO:0015824 proline transport(GO:0015824)
0.0 1.0 GO:0022900 electron transport chain(GO:0022900)
0.0 1.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 0.9 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0043205 fibril(GO:0043205)
0.0 2.9 GO:0070469 respiratory chain(GO:0070469)
0.0 1.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.2 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.9 GO:0000124 SAGA complex(GO:0000124)
0.0 0.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.8 GO:0042581 specific granule(GO:0042581)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.8 GO:0072562 blood microparticle(GO:0072562)
0.2 0.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.2 0.5 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.5 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 5.3 GO:0005509 calcium ion binding(GO:0005509)
1.0 4.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3 3.3 GO:0038191 neuropilin binding(GO:0038191)
0.4 3.0 GO:0050693 LBD domain binding(GO:0050693)
0.1 2.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 1.7 GO:0008276 protein methyltransferase activity(GO:0008276)
0.2 1.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.5 1.4 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 1.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.2 0.8 GO:0004594 pantothenate kinase activity(GO:0004594)