Motif ID: Hand1

Z-value: 0.989


Transcription factors associated with Hand1:

Gene SymbolEntrez IDGene Name
Hand1 ENSMUSG00000037335.7 Hand1



Activity profile for motif Hand1.

activity profile for motif Hand1


Sorted Z-values histogram for motif Hand1

Sorted Z-values for motif Hand1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hand1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_101246960 3.844 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr3_+_86084434 3.230 ENSMUST00000107664.2
 Sh3d19
SH3 domain protein D19
chr2_+_85136355 3.139 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr8_+_84723003 3.116 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr8_-_11312731 3.029 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr10_+_97479470 2.642 ENSMUST00000105287.3
 Dcn
decorin
chr8_+_11312805 2.463 ENSMUST00000033899.7
 Col4a2
collagen, type IV, alpha 2
chr9_+_69454066 2.432 ENSMUST00000134907.1
 Anxa2
annexin A2
chr9_-_51077064 2.352 ENSMUST00000098782.3
 Layn
layilin
chr18_+_24709436 2.260 ENSMUST00000037097.7
 Fhod3
formin homology 2 domain containing 3
chr9_+_69453620 2.185 ENSMUST00000034756.8
ENSMUST00000123470.1
 Anxa2

annexin A2

chr2_+_155940728 2.081 ENSMUST00000109629.1
 Gm15557
predicted gene 15557
chr1_+_75507077 2.073 ENSMUST00000037330.4
 Inha
inhibin alpha
chr11_-_48826500 2.016 ENSMUST00000161192.2
 Gm12184
predicted gene 12184
chr7_+_18884679 1.976 ENSMUST00000032573.6
 Pglyrp1
peptidoglycan recognition protein 1
chr12_+_112588753 1.951 ENSMUST00000101029.2
 Inf2
inverted formin, FH2 and WH2 domain containing
chr13_+_29014399 1.872 ENSMUST00000146336.1
ENSMUST00000130109.1
 A330102I10Rik

RIKEN cDNA A330102I10 gene

chr11_+_3330781 1.805 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chrX_+_10485121 1.797 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr5_-_75978447 1.730 ENSMUST00000113516.1
 Kdr
kinase insert domain protein receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.8 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.6 5.6 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.8 4.6 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.4 3.6 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 3.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 2.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.4 2.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 2.5 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.4 2.4 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.3 2.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 2.3 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 2.3 GO:0007369 gastrulation(GO:0007369)
0.3 2.1 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.0 2.1 GO:0060325 face morphogenesis(GO:0060325)
0.3 2.0 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.2 2.0 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 2.0 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 2.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.6 1.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 5.8 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 5.2 GO:0031985 Golgi cisterna(GO:0031985)
1.5 4.6 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.2 2.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.4 2.5 GO:0044308 axonal spine(GO:0044308)
0.1 2.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.7 2.1 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.6 1.7 GO:0097443 sorting endosome(GO:0097443)
0.3 1.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 1.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.4 1.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.6 GO:0014704 intercalated disc(GO:0014704)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 1.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.4 GO:0005720 nuclear heterochromatin(GO:0005720)
0.4 1.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.6 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.3 3.8 GO:0015026 coreceptor activity(GO:0015026)
0.2 3.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 3.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.2 GO:0070064 proline-rich region binding(GO:0070064)
0.6 3.0 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 3.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 2.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 2.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 2.4 GO:0008430 selenium binding(GO:0008430)
0.1 2.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.8 2.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 2.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 2.1 GO:0034711 inhibin binding(GO:0034711)
0.1 2.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.6 1.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4 1.8 GO:0042834 peptidoglycan binding(GO:0042834)
0.2 1.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.7 GO:0005518 collagen binding(GO:0005518)