Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 2.081

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp143mm10_v2_chr7_+_110061702_1100617320.434.0e-02Click!
Smarcc2mm10_v2_chr10_+_128459236_1284592480.272.1e-01Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.106.4e-01Click!
Six5mm10_v2_chr7_+_19094594_190946330.106.6e-01Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_108213086 3.473 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr14_-_64949632 3.124 ENSMUST00000176832.1
 Hmbox1
homeobox containing 1
chr15_-_43869993 2.817 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr7_+_29768552 2.491 ENSMUST00000032802.4
 Zfp84
zinc finger protein 84
chr15_-_53902472 2.490 ENSMUST00000078673.6
 Samd12
sterile alpha motif domain containing 12
chr7_+_97332311 2.408 ENSMUST00000054107.5
 Kctd21
potassium channel tetramerisation domain containing 21
chr6_+_95117740 2.208 ENSMUST00000032107.7
ENSMUST00000119582.1
 Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr4_+_49521176 2.135 ENSMUST00000042964.6
ENSMUST00000107696.1
 Zfp189

zinc finger protein 189

chr3_+_89520152 2.020 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chrX_+_139684980 1.992 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr4_-_151996113 1.859 ENSMUST00000055688.9
 Phf13
PHD finger protein 13
chr5_+_24423851 1.774 ENSMUST00000141966.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr7_+_44468020 1.672 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr10_-_81407641 1.671 ENSMUST00000140916.1
 Nfic
nuclear factor I/C
chr1_-_134955847 1.617 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr14_-_64949838 1.605 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
 Hmbox1





homeobox containing 1





chr1_-_58973421 1.605 ENSMUST00000173590.1
ENSMUST00000027186.5
 Trak2

trafficking protein, kinesin binding 2

chr13_+_65278839 1.599 ENSMUST00000155732.1
 Zfp369
zinc finger protein 369
chr14_+_79426454 1.527 ENSMUST00000061222.7
 Kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr5_-_149636331 1.518 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 263 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 3.9 GO:0016579 protein deubiquitination(GO:0016579)
0.0 3.6 GO:0098792 xenophagy(GO:0098792)
0.9 3.5 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.6 3.5 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 3.3 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 3.0 GO:0051453 regulation of intracellular pH(GO:0051453)
0.2 2.6 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 2.6 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 2.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.4 2.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.4 2.0 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 1.9 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.4 1.8 GO:0051697 protein delipidation(GO:0051697)
0.3 1.8 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.7 GO:1990403 embryonic brain development(GO:1990403)
0.0 1.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.7 GO:0006813 potassium ion transport(GO:0006813)
0.0 1.6 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.4 1.5 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 5.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
1.2 3.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 2.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.5 GO:0031672 A band(GO:0031672)
0.0 2.1 GO:0030175 filopodium(GO:0030175)
0.1 1.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 1.5 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 1.5 GO:0071439 clathrin complex(GO:0071439)
0.1 1.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.5 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.2 GO:0061617 MICOS complex(GO:0061617)
0.0 1.2 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.2 1.1 GO:0061689 tricellular tight junction(GO:0061689)
0.1 1.1 GO:0034464 BBSome(GO:0034464)
0.1 1.1 GO:0071203 WASH complex(GO:0071203)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 180 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 30.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.5 5.0 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.2 3.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 3.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
1.2 3.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.6 2.9 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 2.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 2.6 GO:0019208 phosphatase regulator activity(GO:0019208)
0.1 2.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 2.2 GO:0031419 cobalamin binding(GO:0031419)
0.1 2.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.5 2.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 2.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.5 GO:0004697 protein kinase C activity(GO:0004697)
0.1 1.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.3 1.4 GO:0000403 Y-form DNA binding(GO:0000403)
0.2 1.4 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 1.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)