Motif ID: Hes5_Hes7

Z-value: 1.248

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes7mm10_v2_chr11_+_69120404_69120404-0.424.8e-02Click!
Hes5mm10_v2_chr4_+_154960915_154960930-0.405.6e-02Click!


Activity profile for motif Hes5_Hes7.

activity profile for motif Hes5_Hes7


Sorted Z-values histogram for motif Hes5_Hes7

Sorted Z-values for motif Hes5_Hes7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 19.994 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 18.947 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr12_+_109549157 5.821 ENSMUST00000128458.1
ENSMUST00000150851.1
 Meg3

maternally expressed 3

chr13_+_51846673 5.133 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr12_+_109459843 4.068 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr1_+_72824482 3.453 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr4_+_137913471 3.193 ENSMUST00000151110.1
 Ece1
endothelin converting enzyme 1
chr6_+_4755327 3.021 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr2_+_163203072 3.005 ENSMUST00000109428.2
 Tox2
TOX high mobility group box family member 2
chr9_+_45117813 2.975 ENSMUST00000170998.1
ENSMUST00000093855.3
 Scn2b

sodium channel, voltage-gated, type II, beta

chr8_-_87804411 2.869 ENSMUST00000165770.2
 Zfp423
zinc finger protein 423
chr15_+_72913357 2.726 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr13_+_108316332 2.307 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr13_+_108316395 2.257 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr10_+_79682169 2.219 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr6_+_91157373 2.042 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr10_+_79682304 2.037 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr8_+_60632818 1.996 ENSMUST00000161421.1
 Mfap3l
microfibrillar-associated protein 3-like
chr8_+_60632856 1.911 ENSMUST00000160719.1
 Mfap3l
microfibrillar-associated protein 3-like
chr8_-_125898291 1.787 ENSMUST00000047239.6
 Pcnxl2
pecanex-like 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 38.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 5.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.5 5.1 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.0 4.6 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.6 4.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 4.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 3.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
1.1 3.2 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.6 3.2 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.6 3.1 GO:0046684 response to pyrethroid(GO:0046684)
0.1 2.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 2.6 GO:0045214 sarcomere organization(GO:0045214)
0.0 2.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 2.0 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 1.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 1.5 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.2 1.3 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.2 1.3 GO:0007288 sperm axoneme assembly(GO:0007288)
0.4 1.1 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.8 GO:0051205 protein insertion into membrane(GO:0051205)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 36.9 GO:0005829 cytosol(GO:0005829)
0.0 4.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.6 3.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 3.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.6 GO:0043034 costamere(GO:0043034)
0.0 2.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 2.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 1.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.3 GO:0097440 apical dendrite(GO:0097440)
0.0 1.3 GO:0005657 replication fork(GO:0005657)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.1 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 38.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 4.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 3.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 3.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 3.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 2.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.5 2.0 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.1 2.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 1.7 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.4 1.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 1.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.3 GO:0045182 translation regulator activity(GO:0045182)
0.0 1.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.4 1.1 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 1.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.6 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.0 0.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)