Motif ID: Hes5_Hes7
Z-value: 1.248
Transcription factors associated with Hes5_Hes7:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hes5 | ENSMUSG00000048001.7 | Hes5 |
Hes7 | ENSMUSG00000023781.2 | Hes7 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hes7 | mm10_v2_chr11_+_69120404_69120404 | -0.42 | 4.8e-02 | Click! |
Hes5 | mm10_v2_chr4_+_154960915_154960930 | -0.40 | 5.6e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.3 | 38.9 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
1.1 | 3.2 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
0.6 | 3.2 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.6 | 3.1 | GO:0046684 | response to pyrethroid(GO:0046684) |
0.6 | 4.3 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
0.5 | 5.1 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
0.4 | 1.1 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
0.2 | 5.8 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.2 | 1.3 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
0.2 | 0.6 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166) |
0.2 | 3.5 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
0.2 | 0.5 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
0.2 | 1.3 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
0.1 | 0.4 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
0.1 | 0.6 | GO:0015744 | succinate transport(GO:0015744) |
0.1 | 1.7 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
0.1 | 1.5 | GO:0033690 | positive regulation of osteoblast proliferation(GO:0033690) |
0.1 | 4.1 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
0.1 | 0.3 | GO:0019478 | D-amino acid catabolic process(GO:0019478) |
0.1 | 0.5 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.1 | 0.7 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.1 | 0.4 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
0.1 | 0.4 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
0.1 | 2.9 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.1 | 2.6 | GO:0045214 | sarcomere organization(GO:0045214) |
0.1 | 0.2 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
0.0 | 0.8 | GO:0051205 | protein insertion into membrane(GO:0051205) |
0.0 | 2.0 | GO:0014003 | oligodendrocyte development(GO:0014003) |
0.0 | 0.4 | GO:0034143 | regulation of toll-like receptor 4 signaling pathway(GO:0034143) |
0.0 | 0.4 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
0.0 | 2.6 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
0.0 | 4.6 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
0.0 | 0.2 | GO:0071360 | cellular response to exogenous dsRNA(GO:0071360) |
0.0 | 0.2 | GO:0070166 | enamel mineralization(GO:0070166) |
0.0 | 0.4 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 0.1 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
0.0 | 0.2 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
0.0 | 0.6 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
0.0 | 0.2 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
0.0 | 0.2 | GO:0000059 | protein import into nucleus, docking(GO:0000059) |
0.0 | 0.1 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.0 | 0.4 | GO:0050850 | positive regulation of calcium-mediated signaling(GO:0050850) |
0.0 | 0.2 | GO:0032402 | melanosome transport(GO:0032402) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.3 | 2.0 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
0.2 | 3.1 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.1 | 0.6 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.1 | 2.6 | GO:0043034 | costamere(GO:0043034) |
0.1 | 1.2 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.0 | 1.3 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 0.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 0.2 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
0.0 | 0.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 2.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.4 | GO:0031527 | filopodium membrane(GO:0031527) |
0.0 | 0.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.1 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.0 | 0.3 | GO:0005652 | nuclear lamina(GO:0005652) |
0.0 | 1.5 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 36.9 | GO:0005829 | cytosol(GO:0005829) |
0.0 | 4.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 1.3 | GO:0005657 | replication fork(GO:0005657) |
0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
0.0 | 1.5 | GO:0016324 | apical plasma membrane(GO:0016324) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 38.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.5 | 2.0 | GO:0035851 | histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851) |
0.4 | 1.3 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
0.4 | 3.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.4 | 3.0 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.4 | 1.1 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
0.3 | 1.7 | GO:0018121 | imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102) |
0.1 | 0.6 | GO:0015141 | succinate transmembrane transporter activity(GO:0015141) |
0.1 | 1.3 | GO:0031996 | thioesterase binding(GO:0031996) |
0.1 | 2.0 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.1 | 4.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
0.1 | 0.4 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
0.1 | 2.2 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.1 | 0.3 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
0.1 | 0.4 | GO:0033192 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.1 | 0.3 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
0.0 | 3.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 1.1 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
0.0 | 0.2 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.0 | 3.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 1.2 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 1.3 | GO:0045182 | translation regulator activity(GO:0045182) |
0.0 | 0.6 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 0.3 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.0 | 0.6 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.0 | 2.7 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.0 | 0.4 | GO:0052771 | coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771) |
0.0 | 0.2 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |