Motif ID: Hey2

Z-value: 0.828


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_30842801-0.612.0e-03Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 172 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_105518736 7.035 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr8_+_87473116 5.262 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr8_+_87472805 3.744 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr4_-_107683576 3.640 ENSMUST00000131776.1
 Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr4_+_116877376 3.486 ENSMUST00000044823.3
 Zswim5
zinc finger SWIM-type containing 5
chr8_+_87472838 3.467 ENSMUST00000180806.2
 Gm2694
predicted gene 2694
chr6_+_47244359 3.202 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr1_-_127677923 3.035 ENSMUST00000160616.1
 Tmem163
transmembrane protein 163
chr4_-_117133953 2.785 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr1_+_72824482 2.670 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr11_-_120348513 2.530 ENSMUST00000071555.6
 Actg1
actin, gamma, cytoplasmic 1
chr11_-_120348475 2.119 ENSMUST00000062147.7
ENSMUST00000128055.1
 Actg1

actin, gamma, cytoplasmic 1

chr1_+_182763961 1.942 ENSMUST00000153348.1
 Susd4
sushi domain containing 4
chr10_-_11080956 1.854 ENSMUST00000105560.1
 Grm1
glutamate receptor, metabotropic 1
chr8_+_119446719 1.823 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr7_+_27486910 1.774 ENSMUST00000008528.7
 Sertad1
SERTA domain containing 1
chr9_+_21165714 1.693 ENSMUST00000039413.8
 Pde4a
phosphodiesterase 4A, cAMP specific
chr10_+_80494835 1.574 ENSMUST00000051773.8
 Onecut3
one cut domain, family member 3
chr7_-_4752972 1.466 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr10_+_69212634 1.406 ENSMUST00000020101.5
 Rhobtb1
Rho-related BTB domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.0 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.1 5.4 GO:0045214 sarcomere organization(GO:0045214)
0.6 3.2 GO:0071205 clustering of voltage-gated potassium channels(GO:0045163) protein localization to juxtaparanode region of axon(GO:0071205)
0.3 2.8 GO:0090166 Golgi disassembly(GO:0090166)
0.1 2.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.5 1.9 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.1 1.9 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.2 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 1.2 GO:0007601 visual perception(GO:0007601)
0.1 1.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 1.0 GO:0060325 face morphogenesis(GO:0060325)
0.4 0.9 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.3 0.9 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 0.9 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 0.9 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 0.9 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 GO:0043034 costamere(GO:0043034)
0.0 4.7 GO:0045177 apical part of cell(GO:0045177)
0.2 3.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 3.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 2.8 GO:0005795 Golgi stack(GO:0005795)
0.2 2.0 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 1.9 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1 1.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.5 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.1 GO:0044194 cytolytic granule(GO:0044194)
0.1 1.1 GO:0005922 connexon complex(GO:0005922)
0.1 1.0 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.7 GO:0045095 keratin filament(GO:0045095)
0.1 0.6 GO:0034715 pICln-Sm protein complex(GO:0034715)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.1 5.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.9 GO:0002020 protease binding(GO:0002020)
0.3 2.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 2.5 GO:0002039 p53 binding(GO:0002039)
0.2 2.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 2.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 1.9 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639)
0.2 1.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.7 GO:0030552 cAMP binding(GO:0030552)
0.0 1.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.9 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)