Motif ID: Hic2

Z-value: 1.823


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.145.2e-01Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 9.416 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr7_-_74554474 6.571 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr19_-_41206774 5.150 ENSMUST00000025986.7
ENSMUST00000169941.1
 Tll2

tolloid-like 2

chr6_+_88724828 4.842 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr5_-_53707532 4.569 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr13_-_54055650 4.453 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr12_+_109459843 4.241 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr7_-_74554726 4.055 ENSMUST00000107453.1
 Slco3a1
solute carrier organic anion transporter family, member 3a1
chr6_-_115994953 3.821 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr1_+_90203980 3.742 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr12_+_109549157 3.719 ENSMUST00000128458.1
ENSMUST00000150851.1
 Meg3

maternally expressed 3

chr2_-_172043466 3.621 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr3_+_123446913 3.464 ENSMUST00000029603.8
 Prss12
protease, serine, 12 neurotrypsin (motopsin)
chr2_-_181156993 3.339 ENSMUST00000055990.7
 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr5_-_128953303 3.200 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr10_-_109010955 3.072 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr11_+_75193783 3.059 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr15_+_99224976 3.010 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr12_+_109453455 2.807 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr2_-_163918683 2.759 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 382 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 11.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.8 10.8 GO:0015732 prostaglandin transport(GO:0015732)
0.3 7.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 5.2 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.0 5.1 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
1.5 4.6 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 4.6 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
1.1 4.3 GO:0003360 brainstem development(GO:0003360)
0.4 4.3 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 4.2 GO:0006414 translational elongation(GO:0006414)
0.6 3.9 GO:0032796 uropod organization(GO:0032796)
0.1 3.7 GO:0031638 zymogen activation(GO:0031638)
1.2 3.6 GO:0086017 Purkinje myocyte action potential(GO:0086017)
0.2 3.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.2 3.5 GO:0019835 cytolysis(GO:0019835)
0.6 3.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.3 3.4 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.2 3.4 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 3.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 12.3 GO:0043196 varicosity(GO:0043196)
0.1 9.7 GO:0043195 terminal bouton(GO:0043195)
0.0 8.4 GO:0009897 external side of plasma membrane(GO:0009897)
1.4 4.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.3 4.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 4.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 4.2 GO:0045298 tubulin complex(GO:0045298)
0.1 4.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 4.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 4.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 3.7 GO:0009925 basal plasma membrane(GO:0009925)
0.3 3.5 GO:0043083 synaptic cleft(GO:0043083)
0.6 3.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 3.3 GO:0031045 dense core granule(GO:0031045)
0.1 3.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 3.0 GO:0098984 neuron to neuron synapse(GO:0098984)
0.1 2.9 GO:0016459 myosin complex(GO:0016459)
0.0 2.8 GO:0097060 synaptic membrane(GO:0097060)
0.9 2.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 12.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.5 10.6 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 7.8 GO:0001653 peptide receptor activity(GO:0001653)
0.2 5.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 4.9 GO:0045499 chemorepellent activity(GO:0045499)
0.2 4.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.7 4.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.6 4.3 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 4.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 3.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 3.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 3.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
1.2 3.7 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.0 3.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 3.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 3.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 3.5 GO:0022839 ion gated channel activity(GO:0022839)
0.6 3.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.2 3.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 3.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)