Motif ID: Hif1a

Z-value: 0.615


Transcription factors associated with Hif1a:

Gene SymbolEntrez IDGene Name
Hif1a ENSMUSG00000021109.7 Hif1a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1amm10_v2_chr12_+_73907904_73907970-0.612.1e-03Click!


Activity profile for motif Hif1a.

activity profile for motif Hif1a


Sorted Z-values histogram for motif Hif1a

Sorted Z-values for motif Hif1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hif1a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_46845832 1.392 ENSMUST00000048209.9
ENSMUST00000092621.4
Ldha

lactate dehydrogenase A

chr16_-_23988852 1.298 ENSMUST00000023151.5
Bcl6
B cell leukemia/lymphoma 6
chr15_-_44788016 1.253 ENSMUST00000090057.4
ENSMUST00000110269.1
Sybu

syntabulin (syntaxin-interacting)

chr6_+_88724828 1.179 ENSMUST00000089449.2
Mgll
monoglyceride lipase
chr6_+_88724412 1.034 ENSMUST00000113585.2
Mgll
monoglyceride lipase
chr6_+_88724667 1.000 ENSMUST00000163271.1
Mgll
monoglyceride lipase
chr15_+_44787746 0.995 ENSMUST00000181839.1
2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr6_+_88724489 0.895 ENSMUST00000113581.1
Mgll
monoglyceride lipase
chr6_+_88724462 0.879 ENSMUST00000113582.1
Mgll
monoglyceride lipase
chr13_-_52981027 0.870 ENSMUST00000071065.7
Nfil3
nuclear factor, interleukin 3, regulated
chr17_-_27133620 0.590 ENSMUST00000118613.1
Uqcc2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr6_-_101377897 0.589 ENSMUST00000075994.6
Pdzrn3
PDZ domain containing RING finger 3
chr4_-_55532453 0.560 ENSMUST00000132746.1
ENSMUST00000107619.2
Klf4

Kruppel-like factor 4 (gut)

chr1_+_55088132 0.552 ENSMUST00000075242.6
Hspe1
heat shock protein 1 (chaperonin 10)
chr5_-_135251209 0.536 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr2_+_71873224 0.492 ENSMUST00000006669.5
Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
chr5_-_122779278 0.489 ENSMUST00000111668.3
Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr10_-_85102487 0.488 ENSMUST00000059383.6
Fhl4
four and a half LIM domains 4
chr1_-_153549697 0.472 ENSMUST00000041874.7
Npl
N-acetylneuraminate pyruvate lyase
chr9_+_21165714 0.469 ENSMUST00000039413.8
Pde4a
phosphodiesterase 4A, cAMP specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.0 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 1.4 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.4 1.3 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 1.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 1.3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 1.0 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.0 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 0.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.7 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.7 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.7 GO:0007528 neuromuscular junction development(GO:0007528)
0.2 0.6 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0 0.5 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.5 GO:0030388 fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.4 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.4 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.0 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.0 GO:0043196 varicosity(GO:0043196)
0.1 1.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.4 GO:0005657 replication fork(GO:0005657)
0.2 1.3 GO:0097433 dense body(GO:0097433)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.1 0.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 0.5 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 0.3 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0097452 GAIT complex(GO:0097452)
0.0 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.2 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 1.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 1.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 1.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 1.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)
0.2 0.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.6 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 0.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.5 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.5 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.5 GO:0030552 cAMP binding(GO:0030552)
0.1 0.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)