Motif ID: Hlf

Z-value: 0.728


Transcription factors associated with Hlf:

Gene SymbolEntrez IDGene Name
Hlf ENSMUSG00000003949.10 Hlf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_90390926-0.077.6e-01Click!


Activity profile for motif Hlf.

activity profile for motif Hlf


Sorted Z-values histogram for motif Hlf

Sorted Z-values for motif Hlf



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_77894096 2.051 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr15_-_88978958 2.027 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr3_+_51559973 2.000 ENSMUST00000180404.1
 5031434O11Rik
RIKEN cDNA 5031434O11 gene
chr6_+_17463749 1.955 ENSMUST00000115443.1
 Met
met proto-oncogene
chr3_+_86070915 1.914 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr19_-_28963863 1.875 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr5_+_3343893 1.794 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr7_-_46667375 1.743 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr3_-_80913528 1.585 ENSMUST00000107743.1
ENSMUST00000029654.8
 Glrb

glycine receptor, beta subunit

chr3_+_127553462 1.583 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr7_+_18884679 1.406 ENSMUST00000032573.6
 Pglyrp1
peptidoglycan recognition protein 1
chr16_+_43510267 1.384 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr3_+_66219909 1.341 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr4_-_151044564 1.183 ENSMUST00000103204.4
 Per3
period circadian clock 3
chr9_-_107668967 1.174 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr5_-_124032214 1.166 ENSMUST00000040967.7
 Vps37b
vacuolar protein sorting 37B (yeast)
chr18_-_35498856 1.032 ENSMUST00000025215.8
 Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr11_+_3330401 1.019 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr3_+_51559757 1.004 ENSMUST00000180616.1
 5031434O11Rik
RIKEN cDNA 5031434O11 gene
chr1_-_140183404 0.950 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.1 GO:0006553 lysine metabolic process(GO:0006553)
0.4 2.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 2.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 1.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.6 1.8 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.2 1.7 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 1.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 1.6 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.3 1.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.4 GO:0098543 detection of bacterium(GO:0016045) negative regulation of natural killer cell activation(GO:0032815) detection of other organism(GO:0098543)
0.0 1.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 1.3 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.4 1.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.3 1.2 GO:0006867 asparagine transport(GO:0006867) glutamine transport(GO:0006868)
0.1 1.2 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.2 1.1 GO:0015862 uridine transport(GO:0015862)
0.2 1.0 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3 0.9 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.3 0.9 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
0.2 0.9 GO:2001204 regulation of osteoclast development(GO:2001204)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0005901 caveola(GO:0005901)
0.0 1.9 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.0 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.1 0.9 GO:0070652 HAUS complex(GO:0070652)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.2 0.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.6 GO:0042629 mast cell granule(GO:0042629)
0.1 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.1 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.2 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.2 GO:0031091 platelet alpha granule(GO:0031091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0008565 protein transporter activity(GO:0008565)
0.5 2.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.5 2.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 1.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.8 GO:0030332 cyclin binding(GO:0030332)
0.6 1.7 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.6 1.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.5 1.6 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.5 1.5 GO:0001851 complement component C3b binding(GO:0001851)
0.4 1.4 GO:0042834 peptidoglycan binding(GO:0042834)
0.3 1.3 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.2 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 0.9 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 0.9 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.2 0.7 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.2 0.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)