Motif ID: Hmbox1

Z-value: 1.166


Transcription factors associated with Hmbox1:

Gene SymbolEntrez IDGene Name
Hmbox1 ENSMUSG00000021972.8 Hmbox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmbox1mm10_v2_chr14_-_64949838_64949886-0.116.2e-01Click!


Activity profile for motif Hmbox1.

activity profile for motif Hmbox1


Sorted Z-values histogram for motif Hmbox1

Sorted Z-values for motif Hmbox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmbox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 15.657 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr6_+_5390387 7.114 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr2_-_172043466 6.602 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr1_-_75278345 5.665 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr13_-_41273977 3.258 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chrX_+_100625737 2.986 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr14_-_93888732 2.809 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr11_-_64436653 2.747 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chrX_+_169685191 2.214 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr10_-_11080956 2.041 ENSMUST00000105560.1
 Grm1
glutamate receptor, metabotropic 1
chr8_+_45507768 1.904 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chrX_-_23266751 1.748 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr9_+_104566677 1.744 ENSMUST00000157006.1
 Cpne4
copine IV
chrX_+_135993820 1.672 ENSMUST00000058119.7
 Arxes2
adipocyte-related X-chromosome expressed sequence 2
chr14_+_66635251 1.667 ENSMUST00000159365.1
ENSMUST00000054661.1
ENSMUST00000159068.1
 Adra1a


adrenergic receptor, alpha 1a


chr13_-_3893556 1.612 ENSMUST00000099946.4
 Net1
neuroepithelial cell transforming gene 1
chr13_-_90905321 1.563 ENSMUST00000109541.3
 Atp6ap1l
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr4_-_97584612 1.548 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr8_+_45658666 1.526 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr10_-_49783259 1.449 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 15.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 7.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 5.7 GO:0009306 protein secretion(GO:0009306)
0.1 4.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 3.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.4 3.0 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.2 2.0 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.6 1.7 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.0 1.7 GO:0000910 cytokinesis(GO:0000910)
0.0 1.7 GO:0045444 fat cell differentiation(GO:0045444)
0.1 1.6 GO:0051451 myoblast migration(GO:0051451)
0.1 1.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 1.4 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.3 1.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.3 1.0 GO:2000834 androgen secretion(GO:0035935) testosterone secretion(GO:0035936) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.2 1.0 GO:0035617 stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 1.0 GO:0030262 cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.9 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.9 GO:0016574 histone ubiquitination(GO:0016574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 7.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
1.1 5.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 5.2 GO:0005874 microtubule(GO:0005874)
0.0 4.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 3.0 GO:0005871 kinesin complex(GO:0005871)
0.0 2.6 GO:0044291 cell-cell contact zone(GO:0044291)
0.3 2.0 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 1.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.1 GO:0030315 T-tubule(GO:0030315)
0.1 1.0 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.9 GO:0033503 HULC complex(GO:0033503)
0.1 0.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 0.8 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 0.7 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.5 GO:0045298 tubulin complex(GO:0045298)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 7.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 4.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 3.6 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 3.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.5 2.0 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639)
0.6 1.7 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.1 1.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 1.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 1.3 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.3 1.2 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.2 1.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.8 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.5 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)