Motif ID: Hmx3

Z-value: 0.424


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_1315428670.155.0e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144893127 1.824 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_-_49757257 1.621 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr12_-_83487708 1.169 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr1_-_190170671 1.157 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr3_+_62419668 1.077 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr15_+_9436028 1.019 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr1_+_165788681 0.874 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr9_-_123678873 0.671 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr14_-_55560340 0.657 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr9_-_123678782 0.631 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr1_-_119836999 0.617 ENSMUST00000163621.1
ENSMUST00000168303.1
 Ptpn4

protein tyrosine phosphatase, non-receptor type 4

chr6_+_92092369 0.490 ENSMUST00000113463.1
 Nr2c2
nuclear receptor subfamily 2, group C, member 2
chr10_+_99263224 0.480 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr4_+_154960915 0.469 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr7_+_25681158 0.454 ENSMUST00000108403.3
 B9d2
B9 protein domain 2
chr7_-_126897424 0.439 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr2_-_130424242 0.432 ENSMUST00000089581.4
 Pced1a
PC-esterase domain containing 1A
chr2_-_72986716 0.429 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr2_-_130424673 0.426 ENSMUST00000110277.1
 Pced1a
PC-esterase domain containing 1A
chr4_-_62470868 0.411 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr7_+_79273201 0.409 ENSMUST00000037315.6
 Abhd2
abhydrolase domain containing 2
chr10_+_106470281 0.392 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr13_+_118714678 0.362 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr2_+_130424321 0.312 ENSMUST00000128994.1
ENSMUST00000028900.9
 Vps16

vacuolar protein sorting 16 (yeast)

chr7_-_45510400 0.305 ENSMUST00000033096.7
 Nucb1
nucleobindin 1
chr7_+_25267669 0.300 ENSMUST00000169266.1
 Cic
capicua homolog (Drosophila)
chr17_-_57247632 0.295 ENSMUST00000005975.6
 Gpr108
G protein-coupled receptor 108
chr11_+_103133303 0.284 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr2_-_45112890 0.276 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr19_+_11965817 0.260 ENSMUST00000025590.9
 Osbp
oxysterol binding protein
chr12_-_83921809 0.229 ENSMUST00000135962.1
ENSMUST00000155112.1
ENSMUST00000136848.1
ENSMUST00000126943.1
 Numb



numb gene homolog (Drosophila)



chr19_-_41933276 0.228 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr14_+_54464141 0.221 ENSMUST00000022782.8
 Lrp10
low-density lipoprotein receptor-related protein 10
chr13_-_92131494 0.194 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chrX_+_159708593 0.191 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chr19_+_8802486 0.176 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr9_+_21955747 0.165 ENSMUST00000053583.5
 Swsap1
SWIM type zinc finger 7 associated protein 1
chr10_+_62980233 0.158 ENSMUST00000131718.1
ENSMUST00000119567.1
ENSMUST00000122231.1
 Rufy2


RUN and FYVE domain-containing 2


chr11_+_103133333 0.150 ENSMUST00000124928.1
ENSMUST00000062530.4
 Hexim2

hexamethylene bis-acetamide inducible 2

chr19_+_41933464 0.150 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr7_+_3645267 0.142 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr3_+_66985947 0.120 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr13_+_23746734 0.097 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr5_-_137684665 0.076 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr2_-_84715160 0.067 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr18_+_61639542 0.042 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr19_-_56822161 0.027 ENSMUST00000118592.1
 A630007B06Rik
RIKEN cDNA A630007B06 gene
chr11_+_114668524 0.021 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
 Rpl38



ribosomal protein L38



chr7_-_127208423 0.020 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b
chr12_-_83921899 0.017 ENSMUST00000117217.1
 Numb
numb gene homolog (Drosophila)
chrM_+_3906 0.014 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr8_-_23237623 0.014 ENSMUST00000033950.5
 Gins4
GINS complex subunit 4 (Sld5 homolog)
chr10_+_115569986 0.009 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene
chr7_-_121035096 0.009 ENSMUST00000065740.2
 Gm9905
predicted gene 9905
chr10_-_80421847 0.005 ENSMUST00000156244.1
 Tcf3
transcription factor 3
chr4_+_65604984 0.004 ENSMUST00000050850.7
ENSMUST00000107366.1
 Trim32

tripartite motif-containing 32


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 1.3 GO:0036233 glycine import(GO:0036233)
0.2 1.8 GO:0042572 retinol metabolic process(GO:0042572)
0.2 0.5 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.5 GO:2000977 regulation of forebrain neuron differentiation(GO:2000977)
0.1 0.4 GO:0071336 lung growth(GO:0060437) positive regulation of fat cell proliferation(GO:0070346) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 1.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.2 GO:0030862 neuroblast division in subventricular zone(GO:0021849) regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.0 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.3 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.4 GO:0032570 response to progesterone(GO:0032570)
0.0 0.5 GO:0048520 positive regulation of behavior(GO:0048520)
0.0 0.3 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.4 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.3 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.2 GO:0071565 nBAF complex(GO:0071565)
0.0 0.3 GO:0033263 CORVET complex(GO:0033263)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 1.2 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)