Motif ID: Hoxa11_Hoxc12

Z-value: 1.091

Transcription factors associated with Hoxa11_Hoxc12:

Gene SymbolEntrez IDGene Name
Hoxa11 ENSMUSG00000038210.9 Hoxa11
Hoxc12 ENSMUSG00000050328.2 Hoxc12



Activity profile for motif Hoxa11_Hoxc12.

activity profile for motif Hoxa11_Hoxc12


Sorted Z-values histogram for motif Hoxa11_Hoxc12

Sorted Z-values for motif Hoxa11_Hoxc12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa11_Hoxc12

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_35076902 12.345 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr1_-_56978534 5.113 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr1_+_43730593 4.942 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr6_+_108213086 4.274 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr14_+_80000292 4.240 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr17_+_6270475 3.298 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr18_+_69346143 3.268 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr17_-_6477102 2.509 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr7_-_142661858 2.335 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr13_+_16014457 2.285 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr3_+_66219909 2.273 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr4_+_136143497 2.147 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr15_-_43869993 2.144 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr5_+_66968961 2.072 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr17_+_22361453 1.891 ENSMUST00000149699.1
ENSMUST00000088765.2
ENSMUST00000072477.4
ENSMUST00000121315.1
 Zfp758



zinc finger protein 758



chr16_-_57231434 1.889 ENSMUST00000023431.6
 Tbc1d23
TBC1 domain family, member 23
chr19_+_58943413 1.690 ENSMUST00000054280.6
 Eno4
enolase 4
chrX_+_41401128 1.620 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr18_+_37655891 1.545 ENSMUST00000097608.2
 3222401L13Rik
RIKEN cDNA 3222401L13 gene
chr1_+_178529113 1.404 ENSMUST00000161017.1
 Kif26b
kinesin family member 26B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.3 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.3 5.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 4.9 GO:0070314 G1 to G0 transition(GO:0070314)
0.7 4.3 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 4.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.1 3.3 GO:0009405 pathogenesis(GO:0009405)
0.3 3.3 GO:0042118 endothelial cell activation(GO:0042118)
0.1 2.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 2.4 GO:0031999 negative regulation of fatty acid beta-oxidation(GO:0031999)
0.8 2.3 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.5 2.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 2.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 2.1 GO:0071398 cellular response to fatty acid(GO:0071398)
0.0 2.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 2.0 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 1.7 GO:0030317 sperm motility(GO:0030317)
0.5 1.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.3 1.3 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.0 1.2 GO:0098792 xenophagy(GO:0098792)
0.4 1.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0000118 histone deacetylase complex(GO:0000118)
1.4 4.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.3 4.2 GO:0042581 specific granule(GO:0042581)
0.3 2.8 GO:0043083 synaptic cleft(GO:0043083)
0.8 2.3 GO:0043512 inhibin A complex(GO:0043512)
0.3 1.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.1 GO:0030673 axolemma(GO:0030673)
0.0 1.1 GO:0005901 caveola(GO:0005901)
0.1 1.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.0 GO:0032587 ruffle membrane(GO:0032587)
0.2 0.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.5 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 12.3 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
1.4 4.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 4.2 GO:0045296 cadherin binding(GO:0045296)
0.8 3.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 3.3 GO:0015643 toxic substance binding(GO:0015643)
0.4 2.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.5 2.3 GO:0001849 complement component C1q binding(GO:0001849)
0.4 2.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 2.1 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.9 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.2 1.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 1.3 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.2 1.1 GO:0098821 BMP receptor activity(GO:0098821)
0.1 1.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.9 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.9 GO:0005112 Notch binding(GO:0005112)
0.0 0.9 GO:0004402 histone acetyltransferase activity(GO:0004402)