Motif ID: Hoxa4

Z-value: 0.905


Transcription factors associated with Hoxa4:

Gene SymbolEntrez IDGene Name
Hoxa4 ENSMUSG00000000942.10 Hoxa4



Activity profile for motif Hoxa4.

activity profile for motif Hoxa4


Sorted Z-values histogram for motif Hoxa4

Sorted Z-values for motif Hoxa4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 3.274 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_+_71528657 3.228 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr1_-_190170671 2.863 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr4_+_144893077 2.812 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 2.624 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_5218546 2.409 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr3_+_5218516 2.009 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr7_-_19699008 1.898 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
Apoe





apolipoprotein E





chr2_-_77519565 1.814 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr13_+_94875600 1.617 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr3_+_86070915 1.612 ENSMUST00000182666.1
Sh3d19
SH3 domain protein D19
chr6_+_8949670 1.582 ENSMUST00000060369.3
Nxph1
neurexophilin 1
chr3_+_5218589 1.529 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr19_-_28967794 1.493 ENSMUST00000162110.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chrX_-_38252398 1.421 ENSMUST00000089056.3
ENSMUST00000089054.4
ENSMUST00000066498.7
Tmem255a


transmembrane protein 255A


chr15_-_56694525 1.316 ENSMUST00000050544.7
Has2
hyaluronan synthase 2
chr5_+_64812336 1.274 ENSMUST00000166409.1
Klf3
Kruppel-like factor 3 (basic)
chr5_+_139543889 1.204 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr1_+_165788681 1.148 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr2_+_109917639 1.136 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 8.6 GO:0042572 retinol metabolic process(GO:0042572)
0.1 3.4 GO:0007638 mechanosensory behavior(GO:0007638)
1.1 3.2 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
1.0 2.9 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 2.8 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.5 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.6 1.9 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.1 1.8 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 1.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 1.6 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.3 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 1.3 GO:0008542 visual learning(GO:0008542)
0.2 1.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.4 1.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 1.1 GO:0042574 isoprenoid catabolic process(GO:0008300) retinal metabolic process(GO:0042574)
0.1 1.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 1.0 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.2 0.8 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 1.9 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.2 0.5 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.5 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.2 GO:0051286 cell tip(GO:0051286)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.2 8.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 7.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 3.1 GO:0050693 LBD domain binding(GO:0050693)
0.6 1.9 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.4 1.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.4 1.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 1.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.7 GO:0043531 ADP binding(GO:0043531)
0.1 0.6 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)