Motif ID: Hoxa7_Hoxc8

Z-value: 0.559

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710734 5.038 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 4.047 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_80000292 3.633 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr5_-_62766153 2.908 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_137169710 2.132 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr7_-_46667375 1.832 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr2_+_116067213 1.622 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr3_+_5218516 1.090 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr2_-_116067391 1.026 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr8_+_45885479 0.894 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr6_+_30541582 0.872 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr9_-_90255927 0.840 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr17_+_88440711 0.827 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr3_-_66296807 0.770 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chr2_+_109917639 0.736 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr15_+_25773985 0.689 ENSMUST00000125667.1
 Myo10
myosin X
chr19_+_55895508 0.635 ENSMUST00000111646.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr8_+_94152607 0.587 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr14_+_54431597 0.583 ENSMUST00000089688.4
 Mmp14
matrix metallopeptidase 14 (membrane-inserted)
chr2_-_177267036 0.573 ENSMUST00000108963.1
 Gm14409
predicted gene 14409
chr3_+_5218589 0.565 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr8_+_23411490 0.562 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr3_+_5218546 0.548 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr14_-_100149764 0.537 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr6_-_118479237 0.514 ENSMUST00000161170.1
 Zfp9
zinc finger protein 9
chr9_-_103228420 0.495 ENSMUST00000126359.1
 Trf
transferrin
chr5_+_66968559 0.493 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr17_-_45659312 0.487 ENSMUST00000120717.1
 Capn11
calpain 11
chr17_-_36032682 0.485 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr13_-_81710937 0.474 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr10_-_86011833 0.460 ENSMUST00000105304.1
ENSMUST00000061699.5
 Bpifc

BPI fold containing family C

chr18_+_37518341 0.449 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr4_-_82850721 0.433 ENSMUST00000139401.1
 Zdhhc21
zinc finger, DHHC domain containing 21
chr10_-_117148474 0.424 ENSMUST00000020381.3
 Frs2
fibroblast growth factor receptor substrate 2
chr5_+_66968416 0.422 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr2_-_79456750 0.410 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr12_-_87775755 0.404 ENSMUST00000164517.2
 Gm21319
predicted gene, 21319
chr2_+_110597298 0.401 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr15_+_98571004 0.391 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr19_+_5474681 0.376 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
 Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr13_+_83732438 0.349 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr11_+_29373618 0.347 ENSMUST00000040182.6
ENSMUST00000109477.1
 Ccdc88a

coiled coil domain containing 88A

chr15_-_37458523 0.337 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr4_+_108719649 0.311 ENSMUST00000178992.1
 3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr2_+_69897255 0.304 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr10_+_97482350 0.285 ENSMUST00000163448.2
 Dcn
decorin
chr7_+_103550368 0.282 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chrX_-_143933089 0.273 ENSMUST00000087313.3
 Dcx
doublecortin
chr5_-_62765618 0.257 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_72284248 0.244 ENSMUST00000097698.4
ENSMUST00000027381.6
 Pecr

peroxisomal trans-2-enoyl-CoA reductase

chrM_+_9870 0.236 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr2_-_45117349 0.234 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr7_+_51621830 0.231 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr17_-_29007925 0.230 ENSMUST00000009138.5
ENSMUST00000119274.1
 Stk38

serine/threonine kinase 38

chrX_+_16619698 0.220 ENSMUST00000026013.5
 Maoa
monoamine oxidase A
chr1_-_134955847 0.216 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chrM_-_14060 0.200 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr1_+_82316452 0.197 ENSMUST00000027322.7
 Rhbdd1
rhomboid domain containing 1
chr6_+_145934113 0.194 ENSMUST00000032383.7
 Sspn
sarcospan
chr9_+_110052016 0.189 ENSMUST00000164930.1
ENSMUST00000163979.1
 Map4

microtubule-associated protein 4

chr13_+_42681513 0.180 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr19_-_32196393 0.170 ENSMUST00000151822.1
 Sgms1
sphingomyelin synthase 1
chr19_-_41933276 0.154 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr7_-_83550258 0.139 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chr13_+_43785107 0.136 ENSMUST00000015540.2
 Cd83
CD83 antigen
chr14_-_36919314 0.135 ENSMUST00000182797.1
 Ccser2
coiled-coil serine rich 2
chr6_+_63255971 0.119 ENSMUST00000159561.1
ENSMUST00000095852.3
 Grid2

glutamate receptor, ionotropic, delta 2

chr4_+_100478806 0.111 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
 Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr14_+_64589802 0.110 ENSMUST00000180610.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr18_+_55057557 0.095 ENSMUST00000181765.1
 Gm4221
predicted gene 4221
chr1_-_134955908 0.084 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
 Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr1_-_24612700 0.080 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr3_+_121291725 0.077 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr10_+_75037066 0.075 ENSMUST00000147802.1
ENSMUST00000020391.5
 Rab36

RAB36, member RAS oncogene family

chr18_-_3281036 0.070 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
 Crem


cAMP responsive element modulator


chr2_+_69897220 0.063 ENSMUST00000055758.9
ENSMUST00000112251.2
 Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr12_+_71170589 0.063 ENSMUST00000129376.1
 2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr2_+_36230426 0.062 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chrM_+_14138 0.061 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr9_-_55919605 0.060 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr4_+_145585166 0.059 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr2_+_83724397 0.048 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
 Itgav


integrin alpha V


chr16_-_50330987 0.046 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr11_-_82890541 0.042 ENSMUST00000092844.6
ENSMUST00000021033.9
ENSMUST00000018985.8
 Rad51d


RAD51 homolog D


chr10_-_76110956 0.035 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr7_+_126950687 0.034 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr2_+_23069210 0.032 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr18_+_32067729 0.031 ENSMUST00000025243.3
 Iws1
IWS1 homolog (S. cerevisiae)
chr10_+_115569986 0.030 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene
chr5_+_29195983 0.027 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
 Rnf32




ring finger protein 32




chr6_+_37870786 0.025 ENSMUST00000120428.1
ENSMUST00000031859.7
 Trim24

tripartite motif-containing 24

chr18_-_10706688 0.017 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
 Abhd3


abhydrolase domain containing 3


chr9_+_113812547 0.013 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 1.8 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 0.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 0.6 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 0.6 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 0.5 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 3.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.5 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.5 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.1 0.4 GO:0060527 prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0 0.6 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.0 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.1 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.2 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.3 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.1 GO:0033762 response to glucagon(GO:0033762)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.0 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.2 GO:0001504 neurotransmitter uptake(GO:0001504)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.1 GO:0043205 fibril(GO:0043205)
0.3 3.6 GO:0042581 specific granule(GO:0042581)
0.1 0.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.5 GO:0097433 dense body(GO:0097433)
0.1 0.6 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.6 1.8 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 3.6 GO:0045296 cadherin binding(GO:0045296)
0.1 0.5 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 3.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.2 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.6 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)