Motif ID: Hoxa7_Hoxc8

Z-value: 0.559

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710734 5.038 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 4.047 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_80000292 3.633 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr5_-_62766153 2.908 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_137169710 2.132 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr7_-_46667375 1.832 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr2_+_116067213 1.622 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr3_+_5218516 1.090 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr2_-_116067391 1.026 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr8_+_45885479 0.894 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr6_+_30541582 0.872 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr9_-_90255927 0.840 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr17_+_88440711 0.827 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr3_-_66296807 0.770 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chr2_+_109917639 0.736 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr15_+_25773985 0.689 ENSMUST00000125667.1
 Myo10
myosin X
chr19_+_55895508 0.635 ENSMUST00000111646.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr8_+_94152607 0.587 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr14_+_54431597 0.583 ENSMUST00000089688.4
 Mmp14
matrix metallopeptidase 14 (membrane-inserted)
chr2_-_177267036 0.573 ENSMUST00000108963.1
 Gm14409
predicted gene 14409

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 9.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 3.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 1.8 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 0.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 0.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 0.6 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 0.6 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 0.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.6 GO:0035988 chondrocyte proliferation(GO:0035988)
0.2 0.5 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.5 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.5 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.1 0.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:0060527 prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.3 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.1 0.2 GO:0042420 dopamine catabolic process(GO:0042420)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.1 GO:0043205 fibril(GO:0043205)
0.3 3.6 GO:0042581 specific granule(GO:0042581)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.1 0.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.6 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.5 GO:0097433 dense body(GO:0097433)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 9.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 3.6 GO:0045296 cadherin binding(GO:0045296)
0.1 3.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.6 1.8 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.6 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.5 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)