Motif ID: Hoxa9_Hoxb9

Z-value: 0.444

Transcription factors associated with Hoxa9_Hoxb9:

Gene SymbolEntrez IDGene Name
Hoxa9 ENSMUSG00000038227.9 Hoxa9
Hoxb9 ENSMUSG00000020875.8 Hoxb9






Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa9_Hoxb9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_142661858 1.271 ENSMUST00000145896.2
Igf2
insulin-like growth factor 2
chr19_-_57197377 0.858 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr19_-_57197435 0.848 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chr15_+_25773985 0.830 ENSMUST00000125667.1
Myo10
myosin X
chr16_-_52454074 0.650 ENSMUST00000023312.7
Alcam
activated leukocyte cell adhesion molecule
chr6_+_49822710 0.617 ENSMUST00000031843.6
Npy
neuropeptide Y
chr15_+_85510812 0.496 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr11_-_79504078 0.471 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr2_-_33086366 0.454 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr6_-_143947092 0.431 ENSMUST00000144289.1
ENSMUST00000111748.1
Sox5

SRY-box containing gene 5

chr19_-_57197496 0.425 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chr2_-_31845925 0.419 ENSMUST00000028188.7
Fibcd1
fibrinogen C domain containing 1
chr6_-_143947061 0.419 ENSMUST00000124233.1
Sox5
SRY-box containing gene 5
chr2_-_33087169 0.404 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr1_+_194619815 0.357 ENSMUST00000027952.5
Plxna2
plexin A2
chr7_-_101870778 0.347 ENSMUST00000001882.4
ENSMUST00000126204.1
ENSMUST00000155311.1
ENSMUST00000106983.1
ENSMUST00000123630.1
Folr1




folate receptor 1 (adult)




chr19_-_57197556 0.338 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chrX_+_159840463 0.337 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr13_+_16014457 0.302 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr3_+_98280427 0.300 ENSMUST00000090746.2
ENSMUST00000120541.1
Hmgcs2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

chr18_+_37400845 0.297 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr4_+_144893127 0.294 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr16_+_10812915 0.290 ENSMUST00000115822.1
Gm11172
predicted gene 11172
chr5_-_73191848 0.287 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr9_+_75311395 0.266 ENSMUST00000076889.6
Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr1_-_163289214 0.265 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr8_+_93810832 0.257 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr2_-_45112890 0.254 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr17_-_6621267 0.247 ENSMUST00000115772.3
Tmem181c-ps
transmembrane protein 181C, pseudogene
chr9_+_121366958 0.242 ENSMUST00000045903.6
Trak1
trafficking protein, kinesin binding 1
chr3_+_66985680 0.237 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr2_+_125136692 0.232 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr2_+_22622183 0.219 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr5_+_137787769 0.198 ENSMUST00000035852.7
Zcwpw1
zinc finger, CW type with PWWP domain 1
chr5_+_145204523 0.189 ENSMUST00000085671.3
ENSMUST00000031601.7
Zkscan5

zinc finger with KRAB and SCAN domains 5

chr8_+_112570043 0.180 ENSMUST00000034225.6
ENSMUST00000118171.1
Cntnap4

contactin associated protein-like 4

chr9_+_92309362 0.174 ENSMUST00000098477.1
ENSMUST00000150594.1
1700057G04Rik

RIKEN cDNA 1700057G04 gene

chr7_+_28277706 0.171 ENSMUST00000094651.2
Eid2b
EP300 interacting inhibitor of differentiation 2B
chr4_-_133967296 0.168 ENSMUST00000105893.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr10_-_63927434 0.164 ENSMUST00000079279.3
Gm10118
predicted gene 10118
chr2_-_80447625 0.161 ENSMUST00000028389.3
Frzb
frizzled-related protein
chr2_-_67433181 0.158 ENSMUST00000180773.1
Gm26727
predicted gene, 26727
chr2_-_58052832 0.158 ENSMUST00000090940.5
Ermn
ermin, ERM-like protein
chr5_+_34999111 0.156 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr1_+_24005505 0.156 ENSMUST00000181961.1
Gm26524
predicted gene, 26524
chrX_-_134541847 0.154 ENSMUST00000054213.4
Timm8a1
translocase of inner mitochondrial membrane 8A1
chr7_+_45062429 0.153 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip



nitric oxide synthase interacting protein



chr2_+_180967291 0.149 ENSMUST00000108859.1
Arfgap1
ADP-ribosylation factor GTPase activating protein 1
chr12_-_100159601 0.149 ENSMUST00000021596.7
Nrde2
nrde-2 necessary for RNA interference, domain containing
chr7_-_45062393 0.147 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr7_-_127449109 0.144 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr7_-_127448993 0.141 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr7_+_28693997 0.138 ENSMUST00000108280.1
Fbxo27
F-box protein 27
chr11_-_109472611 0.136 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr11_-_109298066 0.135 ENSMUST00000106706.1
Rgs9
regulator of G-protein signaling 9
chr10_-_80590292 0.134 ENSMUST00000003436.5
Abhd17a
abhydrolase domain containing 17A
chr4_-_49597860 0.134 ENSMUST00000042750.2
Tmem246
transmembrane protein 246
chr14_-_70323783 0.131 ENSMUST00000151011.1
Slc39a14
solute carrier family 39 (zinc transporter), member 14
chr3_+_138065052 0.129 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr3_-_95106907 0.120 ENSMUST00000107233.2
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr5_+_34999070 0.119 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr2_+_32395896 0.112 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr14_+_105681824 0.103 ENSMUST00000073238.6
Gm10076
predicted gene 10076
chr9_-_19928282 0.102 ENSMUST00000082002.5
Gm7808
predicted pseudogene 7808
chr5_-_62766153 0.101 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_-_136053343 0.101 ENSMUST00000102536.4
Rpl11
ribosomal protein L11
chr18_-_31447383 0.097 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr5_-_107869153 0.094 ENSMUST00000128723.1
ENSMUST00000124034.1
Evi5

ecotropic viral integration site 5

chr7_+_142533012 0.092 ENSMUST00000038675.6
Mrpl23
mitochondrial ribosomal protein L23
chr7_+_30231884 0.091 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr4_+_133130505 0.091 ENSMUST00000084241.5
ENSMUST00000138831.1
Wasf2

WAS protein family, member 2

chr16_-_17531019 0.091 ENSMUST00000142666.1
ENSMUST00000100125.3
Thap7

THAP domain containing 7

chr9_+_122351555 0.089 ENSMUST00000156520.1
Abhd5
abhydrolase domain containing 5
chr7_-_30232186 0.085 ENSMUST00000006254.5
Tbcb
tubulin folding cofactor B
chr7_+_44896077 0.082 ENSMUST00000071207.7
ENSMUST00000166849.1
ENSMUST00000168712.1
ENSMUST00000168389.1
Fuz



fuzzy homolog (Drosophila)



chr16_+_91225550 0.080 ENSMUST00000035608.8
Olig2
oligodendrocyte transcription factor 2
chr11_-_115933464 0.080 ENSMUST00000021097.3
Recql5
RecQ protein-like 5
chr5_-_145201829 0.079 ENSMUST00000162220.1
ENSMUST00000031632.8
Zkscan14

zinc finger with KRAB and SCAN domains 14

chr4_+_44012638 0.075 ENSMUST00000107847.3
ENSMUST00000170241.1
Clta

clathrin, light polypeptide (Lca)

chr8_+_120488416 0.073 ENSMUST00000034279.9
Gse1
genetic suppressor element 1
chr8_-_33843562 0.073 ENSMUST00000183062.1
Rbpms
RNA binding protein gene with multiple splicing
chr7_-_38271310 0.071 ENSMUST00000032585.6
Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr17_-_45572495 0.070 ENSMUST00000130406.1
Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr4_+_44012661 0.067 ENSMUST00000107849.3
ENSMUST00000107851.3
ENSMUST00000107845.3
Clta


clathrin, light polypeptide (Lca)


chr5_+_63812447 0.062 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr17_-_70998010 0.062 ENSMUST00000024846.6
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr6_-_124965207 0.062 ENSMUST00000148485.1
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr2_-_165287755 0.060 ENSMUST00000109298.1
ENSMUST00000109299.1
ENSMUST00000130393.1
ENSMUST00000017808.7
ENSMUST00000131409.1
ENSMUST00000156134.1
ENSMUST00000133961.1
Slc35c2






solute carrier family 35, member C2






chr8_-_111992258 0.059 ENSMUST00000034427.5
ENSMUST00000139820.1
Adat1

adenosine deaminase, tRNA-specific 1

chr3_-_113574242 0.055 ENSMUST00000142505.2
Amy1
amylase 1, salivary
chr18_-_31317043 0.054 ENSMUST00000139924.1
ENSMUST00000153060.1
Rit2

Ras-like without CAAX 2

chr15_+_81936753 0.050 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr3_+_108653931 0.046 ENSMUST00000029483.8
ENSMUST00000124384.1
Clcc1

chloride channel CLIC-like 1

chr17_+_35861343 0.046 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr7_+_56050135 0.045 ENSMUST00000076226.6
Herc2
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2
chr18_+_12599894 0.044 ENSMUST00000169401.1
Ttc39c
tetratricopeptide repeat domain 39C
chr12_+_112620030 0.044 ENSMUST00000180015.1
ENSMUST00000021726.6
Adssl1

adenylosuccinate synthetase like 1

chr19_-_7341792 0.041 ENSMUST00000164205.1
ENSMUST00000165286.1
ENSMUST00000168324.1
ENSMUST00000032557.8
Mark2



MAP/microtubule affinity-regulating kinase 2



chr6_+_147042755 0.037 ENSMUST00000036111.7
Mrps35
mitochondrial ribosomal protein S35
chr2_-_177267036 0.035 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr7_-_130772652 0.033 ENSMUST00000057134.4
Etos1
ectopic ossification 1
chr13_-_91388079 0.031 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr1_-_65051119 0.030 ENSMUST00000161960.1
ENSMUST00000087359.5
Cryge

crystallin, gamma E

chr3_+_66985647 0.030 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr5_+_31452427 0.030 ENSMUST00000076264.4
Zfp512
zinc finger protein 512
chr15_-_79062866 0.029 ENSMUST00000151889.1
ENSMUST00000040676.4
Ankrd54

ankyrin repeat domain 54

chr18_+_37655891 0.027 ENSMUST00000097608.2
3222401L13Rik
RIKEN cDNA 3222401L13 gene
chr5_+_115235836 0.026 ENSMUST00000081497.6
Pop5
processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
chr19_+_44203265 0.025 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr8_+_27042555 0.023 ENSMUST00000033875.8
ENSMUST00000098851.4
Prosc

proline synthetase co-transcribed

chr19_-_7341848 0.023 ENSMUST00000171393.1
Mark2
MAP/microtubule affinity-regulating kinase 2
chr9_+_45055166 0.023 ENSMUST00000114664.1
ENSMUST00000093856.3
Mpzl3

myelin protein zero-like 3

chr5_-_32746317 0.023 ENSMUST00000135248.1
Pisd
phosphatidylserine decarboxylase
chr3_-_96905294 0.021 ENSMUST00000029738.7
Gpr89
G protein-coupled receptor 89
chrX_+_56447965 0.019 ENSMUST00000079663.6
Gm2174
predicted gene 2174
chr15_+_81936911 0.016 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr3_+_66985700 0.015 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chrX_+_159303266 0.014 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr2_+_28205648 0.013 ENSMUST00000102879.3
ENSMUST00000028177.4
Olfm1

olfactomedin 1

chr3_+_24333046 0.012 ENSMUST00000077389.6
Gm7536
predicted gene 7536
chr3_-_96197580 0.011 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr7_+_103550368 0.007 ENSMUST00000106888.1
Olfr613
olfactory receptor 613

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.6 GO:0019732 antifungal humoral response(GO:0019732)
0.1 0.3 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.1 0.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 0.3 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.2 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.3 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.3 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.4 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.1 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.0 2.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.3 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:0097278 complement-dependent cytotoxicity(GO:0097278)
0.0 0.5 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.3 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.2 GO:0032225 regulation of synaptic transmission, dopaminergic(GO:0032225)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 2.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.1 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.4 GO:0008061 chitin binding(GO:0008061)
0.1 1.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0002135 CTP binding(GO:0002135)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)