Motif ID: Hoxb1

Z-value: 0.522


Transcription factors associated with Hoxb1:

Gene SymbolEntrez IDGene Name
Hoxb1 ENSMUSG00000018973.2 Hoxb1



Activity profile for motif Hoxb1.

activity profile for motif Hoxb1


Sorted Z-values histogram for motif Hoxb1

Sorted Z-values for motif Hoxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_119053339 1.954 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr2_+_65845833 1.681 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chrX_+_143518671 1.407 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr1_+_127306706 1.388 ENSMUST00000171405.1
 Mgat5
mannoside acetylglucosaminyltransferase 5
chr5_+_139543889 1.360 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr1_+_153665274 1.226 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr8_-_8639363 1.060 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr10_-_92162753 1.039 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr7_+_73391160 1.032 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr19_-_41743665 0.969 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr2_+_65845767 0.820 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr3_+_127633134 0.815 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr1_-_119053619 0.807 ENSMUST00000062483.8
 Gli2
GLI-Kruppel family member GLI2
chr12_+_38780284 0.649 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr4_+_103114712 0.644 ENSMUST00000143417.1
 Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr2_+_84840612 0.629 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr8_-_87959560 0.538 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr12_-_15816762 0.498 ENSMUST00000020922.7
 Trib2
tribbles homolog 2 (Drosophila)
chr10_+_4266323 0.471 ENSMUST00000045730.5
 Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr10_-_63421739 0.462 ENSMUST00000054760.4
 Gm7075
predicted gene 7075
chr4_-_103114555 0.451 ENSMUST00000106868.3
 Wdr78
WD repeat domain 78
chr17_+_26941420 0.444 ENSMUST00000081285.3
ENSMUST00000177932.1
 Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

chr11_+_97415527 0.431 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr4_-_103114238 0.429 ENSMUST00000036451.8
ENSMUST00000036557.8
 Wdr78

WD repeat domain 78

chr11_-_40755201 0.417 ENSMUST00000020576.7
 Ccng1
cyclin G1
chr8_-_105471481 0.405 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr2_+_124610278 0.387 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr1_-_135688094 0.386 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr1_+_178798438 0.350 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr2_+_124610573 0.337 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr4_-_35845204 0.326 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr9_+_65890237 0.322 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chrX_+_110814390 0.287 ENSMUST00000078229.3
 Pou3f4
POU domain, class 3, transcription factor 4
chr14_-_69503220 0.279 ENSMUST00000180059.2
 Gm21464
predicted gene, 21464
chr1_-_157412576 0.266 ENSMUST00000078308.6
ENSMUST00000139470.1
 Rasal2

RAS protein activator like 2

chr10_-_33624587 0.256 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr10_+_127677064 0.250 ENSMUST00000118612.1
ENSMUST00000048099.4
 Tmem194

transmembrane protein 194

chr5_+_19907774 0.234 ENSMUST00000115267.2
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr18_-_56562215 0.233 ENSMUST00000170309.1
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr2_-_153529941 0.229 ENSMUST00000035346.7
 8430427H17Rik
RIKEN cDNA 8430427H17 gene
chr3_-_88762244 0.229 ENSMUST00000183267.1
 Syt11
synaptotagmin XI
chr18_-_56562261 0.228 ENSMUST00000066208.6
ENSMUST00000172734.1
 Aldh7a1

aldehyde dehydrogenase family 7, member A1

chr15_-_95528702 0.227 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr11_+_75486813 0.218 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
 Prpf8


pre-mRNA processing factor 8


chr4_-_91399984 0.208 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr16_-_56024628 0.204 ENSMUST00000119981.1
ENSMUST00000096021.3
 Pcnp

PEST proteolytic signal containing nuclear protein

chr5_+_119834663 0.168 ENSMUST00000018407.6
 Tbx5
T-box 5
chr18_-_56562187 0.155 ENSMUST00000171844.2
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr11_-_98022594 0.114 ENSMUST00000103144.3
ENSMUST00000017552.6
ENSMUST00000092736.4
ENSMUST00000107562.1
 Cacnb1



calcium channel, voltage-dependent, beta 1 subunit



chr3_-_58525867 0.101 ENSMUST00000029385.7
 Serp1
stress-associated endoplasmic reticulum protein 1
chr7_+_48789003 0.085 ENSMUST00000118927.1
ENSMUST00000125280.1
 Zdhhc13

zinc finger, DHHC domain containing 13

chr8_-_83458386 0.085 ENSMUST00000081506.3
 Scoc
short coiled-coil protein
chr5_-_24527276 0.083 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr17_+_34647128 0.080 ENSMUST00000015605.8
ENSMUST00000182587.1
 Atf6b

activating transcription factor 6 beta

chr4_+_43669610 0.069 ENSMUST00000107866.1
 Tmem8b
transmembrane protein 8B
chr17_+_34647187 0.067 ENSMUST00000173984.1
 Atf6b
activating transcription factor 6 beta
chr6_+_142413441 0.067 ENSMUST00000088263.4
 B230216G23Rik
RIKEN cDNA B230216G23 gene
chr16_-_97962581 0.067 ENSMUST00000113734.2
ENSMUST00000052089.7
ENSMUST00000063605.7
 Zbtb21


zinc finger and BTB domain containing 21


chr4_-_63662910 0.065 ENSMUST00000184252.1
 Gm11214
predicted gene 11214
chr2_+_119972699 0.065 ENSMUST00000066058.7
 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr9_-_108083330 0.059 ENSMUST00000159372.1
ENSMUST00000160249.1
 Rnf123

ring finger protein 123

chr10_+_81628540 0.043 ENSMUST00000123896.1
 Ankrd24
ankyrin repeat domain 24
chr3_+_41564880 0.043 ENSMUST00000168086.1
 Phf17
PHD finger protein 17
chr17_+_29490812 0.037 ENSMUST00000024811.6
 Pim1
proviral integration site 1
chr15_+_89253035 0.035 ENSMUST00000088788.3
 Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr3_-_65958236 0.031 ENSMUST00000029416.7
 Ccnl1
cyclin L1
chr17_-_85688252 0.023 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chr3_+_58526303 0.013 ENSMUST00000138848.1
 Eif2a
eukaryotic translation initiation factor 2A
chr5_+_136967859 0.012 ENSMUST00000001790.5
 Cldn15
claudin 15
chr6_-_124464772 0.012 ENSMUST00000008297.4
 Clstn3
calsyntenin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0060032 notochord regression(GO:0060032)
0.2 1.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 1.0 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 1.1 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 1.0 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 1.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.2 GO:1905154 negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154)
0.1 1.4 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.5 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.2 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
0.0 2.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.3 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 0.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.3 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.0 GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis(GO:0072038)
0.0 0.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.6 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 1.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.1 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 GO:0097542 ciliary tip(GO:0097542)
0.1 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 0.6 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.1 1.0 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.0 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 0.2 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.5 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 5.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)