Motif ID: Hoxb2_Dlx2

Z-value: 0.599

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.405.8e-02Click!


Activity profile for motif Hoxb2_Dlx2.

activity profile for motif Hoxb2_Dlx2


Sorted Z-values histogram for motif Hoxb2_Dlx2

Sorted Z-values for motif Hoxb2_Dlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 10.064 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_+_8948608 4.203 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr6_-_23248264 3.661 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_+_38783503 3.010 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_38780284 2.977 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr12_+_38780817 2.977 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr14_-_48665098 2.242 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_72986716 2.091 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr3_+_55782500 2.056 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr10_-_45470201 1.897 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr9_-_79977782 1.740 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr3_-_116253467 1.717 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr3_+_125404072 1.472 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr6_+_4755327 1.428 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr3_-_86548268 1.395 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr12_+_38783455 1.336 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr3_+_125404292 1.327 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_134236483 1.318 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr13_-_114458720 1.311 ENSMUST00000022287.5
 Fst
follistatin
chr4_+_8690399 1.302 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 10.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 7.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.6 3.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 2.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 1.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.3 1.8 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.3 1.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 1.4 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 1.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.4 1.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 1.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.3 1.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.2 GO:0043129 surfactant homeostasis(GO:0043129)
0.1 1.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 1.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 1.1 GO:0019228 neuronal action potential(GO:0019228)
0.1 1.0 GO:0060013 righting reflex(GO:0060013)
0.1 0.9 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.9 GO:0021978 telencephalon regionalization(GO:0021978)
0.1 0.9 GO:0031017 exocrine pancreas development(GO:0031017)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.6 GO:0030315 T-tubule(GO:0030315)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.8 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 0.7 GO:0005871 kinesin complex(GO:0005871)
0.1 0.6 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0000786 nucleosome(GO:0000786)
0.1 0.4 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.1 0.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 12.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 2.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.3 GO:0048185 activin binding(GO:0048185)
0.1 1.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.9 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.7 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.1 0.6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.6 GO:0042393 histone binding(GO:0042393)
0.1 0.5 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.5 GO:0016500 protein-hormone receptor activity(GO:0016500)