Motif ID: Hoxb5

Z-value: 0.675


Transcription factors associated with Hoxb5:

Gene SymbolEntrez IDGene Name
Hoxb5 ENSMUSG00000038700.3 Hoxb5



Activity profile for motif Hoxb5.

activity profile for motif Hoxb5


Sorted Z-values histogram for motif Hoxb5

Sorted Z-values for motif Hoxb5



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_125532377 5.034 ENSMUST00000031446.6
 Tmem132b
transmembrane protein 132B
chr3_-_85722474 3.395 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr6_-_18514802 3.370 ENSMUST00000090601.5
 Cttnbp2
cortactin binding protein 2
chr17_+_35076902 2.987 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr1_-_56971762 2.924 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr17_+_35077080 2.839 ENSMUST00000172959.1
 Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr4_+_11704439 1.560 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr5_-_114273702 1.513 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr6_+_141249161 1.437 ENSMUST00000043259.7
 Pde3a
phosphodiesterase 3A, cGMP inhibited
chrX_-_10117597 1.367 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
 Srpx


sushi-repeat-containing protein


chr11_+_74619594 1.355 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr2_+_85136355 1.235 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr2_+_116067933 1.148 ENSMUST00000156095.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr12_-_78983476 1.092 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr12_-_78980758 1.078 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr10_+_128909866 1.033 ENSMUST00000026407.7
 Cd63
CD63 antigen
chrX_+_7723278 1.031 ENSMUST00000144148.1
 Wdr45
WD repeat domain 45
chr3_-_103737995 0.929 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr10_-_127211528 0.835 ENSMUST00000013970.7
 Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr7_+_45017953 0.819 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr14_+_32159865 0.794 ENSMUST00000163336.1
ENSMUST00000169722.1
ENSMUST00000168385.1
 Ncoa4


nuclear receptor coactivator 4


chr6_+_121636173 0.776 ENSMUST00000032203.7
 A2m
alpha-2-macroglobulin
chr2_-_116065798 0.736 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2

chrM_+_11734 0.681 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr7_+_127841817 0.658 ENSMUST00000121705.1
 Stx4a
syntaxin 4A (placental)
chr7_+_127841752 0.656 ENSMUST00000033075.7
 Stx4a
syntaxin 4A (placental)
chr7_+_25627604 0.621 ENSMUST00000076034.6
 B3gnt8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr3_-_89160155 0.611 ENSMUST00000029686.3
 Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr7_-_109083284 0.587 ENSMUST00000120876.1
ENSMUST00000055993.6
 Ric3

resistance to inhibitors of cholinesterase 3 homolog (C. elegans)

chr17_+_47593444 0.565 ENSMUST00000182209.1
 Ccnd3
cyclin D3
chr17_+_47593516 0.533 ENSMUST00000182874.1
 Ccnd3
cyclin D3
chr9_-_35116804 0.521 ENSMUST00000034537.6
 St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr14_+_55560010 0.511 ENSMUST00000147981.1
ENSMUST00000133256.1
 Dcaf11

DDB1 and CUL4 associated factor 11

chr17_-_47691403 0.495 ENSMUST00000113299.1
ENSMUST00000152214.1
 Gm21981
Prickle4
predicted gene 21981
prickle homolog 4 (Drosophila)
chr10_-_81014902 0.461 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
 Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr4_-_131821516 0.425 ENSMUST00000097860.2
 Ptpru
protein tyrosine phosphatase, receptor type, U
chr17_-_57087729 0.399 ENSMUST00000071135.5
 Tubb4a
tubulin, beta 4A class IVA
chr14_+_55559993 0.386 ENSMUST00000117236.1
 Dcaf11
DDB1 and CUL4 associated factor 11
chr17_+_57105385 0.359 ENSMUST00000039490.7
 Tnfsf9
tumor necrosis factor (ligand) superfamily, member 9
chr12_+_17924294 0.355 ENSMUST00000169657.1
 B430203G13Rik
RIKEN cDNA B430203G13 gene
chr10_+_80300997 0.333 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr8_-_25597459 0.306 ENSMUST00000079160.6
 Letm2
leucine zipper-EF-hand containing transmembrane protein 2
chr17_+_94873986 0.285 ENSMUST00000108007.4
 Gm20939
predicted gene, 20939
chr4_-_141874879 0.282 ENSMUST00000036854.3
 Efhd2
EF hand domain containing 2
chr4_+_123233556 0.279 ENSMUST00000040821.4
 Heyl
hairy/enhancer-of-split related with YRPW motif-like
chr6_+_86438360 0.278 ENSMUST00000050497.7
 C87436
expressed sequence C87436
chr5_+_112449405 0.262 ENSMUST00000100882.2
 Gm6588
predicted gene 6588
chr7_+_19004047 0.239 ENSMUST00000053713.3
 Irf2bp1
interferon regulatory factor 2 binding protein 1
chr5_-_137786681 0.237 ENSMUST00000132726.1
 Mepce
methylphosphate capping enzyme
chr2_-_167062607 0.236 ENSMUST00000128676.1
 Znfx1
zinc finger, NFX1-type containing 1
chr10_-_88683021 0.230 ENSMUST00000004473.8
 Spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr17_+_47385386 0.230 ENSMUST00000024774.7
ENSMUST00000145462.1
 Guca1b

guanylate cyclase activator 1B

chr9_+_20581296 0.189 ENSMUST00000115557.2
 Zfp846
zinc finger protein 846
chr2_-_153225396 0.186 ENSMUST00000099194.2
 Tspyl3
TSPY-like 3
chr16_+_17070127 0.174 ENSMUST00000115729.1
 Ypel1
yippee-like 1 (Drosophila)
chr7_-_133709051 0.170 ENSMUST00000124759.1
ENSMUST00000106144.1
 Uros

uroporphyrinogen III synthase

chr16_+_17070281 0.164 ENSMUST00000090199.3
 Ypel1
yippee-like 1 (Drosophila)
chr8_+_95081187 0.159 ENSMUST00000034239.7
 Katnb1
katanin p80 (WD40-containing) subunit B 1
chr14_-_41004517 0.158 ENSMUST00000153830.1
 Fam213a
family with sequence similarity 213, member A
chr5_-_137786651 0.150 ENSMUST00000031740.9
 Mepce
methylphosphate capping enzyme
chr8_-_85840877 0.149 ENSMUST00000034140.7
 Itfg1
integrin alpha FG-GAP repeat containing 1
chr17_+_31386244 0.148 ENSMUST00000134525.1
ENSMUST00000127929.1
 Pde9a

phosphodiesterase 9A

chr10_-_63927434 0.147 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr7_+_119895836 0.144 ENSMUST00000106518.1
ENSMUST00000054440.3
 Lyrm1

LYR motif containing 1

chr17_+_31386218 0.134 ENSMUST00000047168.5
 Pde9a
phosphodiesterase 9A
chr7_-_123500449 0.126 ENSMUST00000042470.7
ENSMUST00000128217.1
 Zkscan2

zinc finger with KRAB and SCAN domains 2

chr7_+_133709333 0.124 ENSMUST00000033282.4
 Bccip
BRCA2 and CDKN1A interacting protein
chr11_-_96075655 0.123 ENSMUST00000090541.5
 Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr4_-_108848619 0.113 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr7_-_119896285 0.111 ENSMUST00000106519.1
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr5_+_117133567 0.102 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr2_+_102659213 0.097 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr18_+_74268251 0.097 ENSMUST00000097530.3
 Mbd1
methyl-CpG binding domain protein 1
chr11_+_97798995 0.091 ENSMUST00000143571.1
 Lasp1
LIM and SH3 protein 1
chr16_+_17070220 0.073 ENSMUST00000141959.1
 Ypel1
yippee-like 1 (Drosophila)
chr1_+_164249233 0.071 ENSMUST00000169394.1
 Slc19a2
solute carrier family 19 (thiamine transporter), member 2
chr15_-_28025834 0.071 ENSMUST00000090247.5
 Trio
triple functional domain (PTPRF interacting)
chr8_+_70594466 0.066 ENSMUST00000019283.9
 Isyna1
myo-inositol 1-phosphate synthase A1
chr1_-_166409773 0.044 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
 Pogk




pogo transposable element with KRAB domain




chrX_+_20687954 0.035 ENSMUST00000115364.1
 Cdk16
cyclin-dependent kinase 16
chrX_+_151046131 0.031 ENSMUST00000112685.1
 Fgd1
FYVE, RhoGEF and PH domain containing 1
chr7_+_119896292 0.024 ENSMUST00000106517.1
 Lyrm1
LYR motif containing 1
chr15_+_12205009 0.020 ENSMUST00000038172.8
 Mtmr12
myotubularin related protein 12
chr11_-_69197809 0.020 ENSMUST00000094078.3
ENSMUST00000021262.3
 Alox8

arachidonate 8-lipoxygenase

chr18_-_16809233 0.018 ENSMUST00000025166.7
 Cdh2
cadherin 2
chr7_-_100964371 0.002 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.4 1.3 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.4 1.4 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 0.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.2 5.8 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 1.0 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.2 2.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 1.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 0.8 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 1.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.4 GO:0040031 snRNA modification(GO:0040031)
0.1 0.3 GO:2000823 regulation of androgen receptor activity(GO:2000823)
0.1 0.4 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1 1.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 0.2 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.6 GO:0051310 metaphase plate congression(GO:0051310)
0.0 0.6 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.2 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0061101 neuroendocrine cell differentiation(GO:0061101)
0.0 0.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.1 GO:0015888 thiamine transport(GO:0015888)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.8 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.6 GO:0006023 aminoglycan biosynthetic process(GO:0006023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.2 1.3 GO:0000322 storage vacuole(GO:0000322)
0.1 0.6 GO:0044316 cone cell pedicle(GO:0044316)
0.1 1.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 1.6 GO:0051233 spindle midzone(GO:0051233)
0.0 2.2 GO:0005776 autophagosome(GO:0005776)
0.0 0.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 2.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.4 GO:0008021 synaptic vesicle(GO:0008021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.4 3.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 1.3 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.3 0.8 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.3 0.8 GO:0019966 C-X-C chemokine binding(GO:0019958) interleukin-1 binding(GO:0019966) tumor necrosis factor binding(GO:0043120)
0.2 0.6 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.6 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.2 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.1 0.5 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 2.4 GO:0019003 GDP binding(GO:0019003)
0.0 1.4 GO:0030552 cAMP binding(GO:0030552)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.1 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)