Motif ID: Hoxb8_Pdx1

Z-value: 0.663

Transcription factors associated with Hoxb8_Pdx1:

Gene SymbolEntrez IDGene Name
Hoxb8 ENSMUSG00000056648.4 Hoxb8
Pdx1 ENSMUSG00000029644.6 Pdx1



Activity profile for motif Hoxb8_Pdx1.

activity profile for motif Hoxb8_Pdx1


Sorted Z-values histogram for motif Hoxb8_Pdx1

Sorted Z-values for motif Hoxb8_Pdx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb8_Pdx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_4779513 1.768 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr8_+_118283719 1.702 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr1_-_126830632 1.691 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr1_+_153665274 1.248 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr6_+_142413441 1.156 ENSMUST00000088263.4
 B230216G23Rik
RIKEN cDNA B230216G23 gene
chr6_+_96115249 1.138 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr12_+_58211772 1.135 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr5_+_106609098 1.123 ENSMUST00000167618.1
 Gm17304
predicted gene, 17304
chr14_-_34374617 1.108 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr7_-_49636847 1.076 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr3_+_124321031 1.029 ENSMUST00000058994.4
 Tram1l1
translocation associated membrane protein 1-like 1
chr19_+_23723279 1.010 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr1_-_78968079 1.008 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr17_-_53539411 0.987 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr1_+_10993452 0.984 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_+_140367494 0.979 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr1_-_126830786 0.956 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr1_-_33907721 0.913 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr17_+_39846958 0.904 ENSMUST00000182010.1
 Gm26924
predicted gene, 26924
chr2_-_58357752 0.890 ENSMUST00000112608.2
ENSMUST00000112607.2
ENSMUST00000028178.7
 Acvr1c


activin A receptor, type IC



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 1.7 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.5 1.6 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.3 1.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.0 1.6 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.1 1.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.4 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 1.2 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 1.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 1.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 1.1 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.1 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 1.0 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.0 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 0.9 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.8 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.8 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.1 1.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 1.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 1.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.3 0.9 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.7 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 0.7 GO:0070938 contractile ring(GO:0070938)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.6 GO:0008091 spectrin(GO:0008091)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.3 GO:0044299 C-fiber(GO:0044299)
0.0 0.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.3 GO:0031933 telomeric heterochromatin(GO:0031933)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.8 GO:0042169 SH2 domain binding(GO:0042169)
0.3 1.6 GO:0055100 adiponectin binding(GO:0055100)
0.2 1.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 1.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 1.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 1.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.1 GO:0030552 cAMP binding(GO:0030552)
0.2 1.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 0.9 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.9 GO:0018602 sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.1 0.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.7 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)