Motif ID: Hoxc10

Z-value: 0.549


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_25469742 3.797 ENSMUST00000114259.2
ENSMUST00000015234.6
Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 3.164 ENSMUST00000114251.1
Ptgds
prostaglandin D2 synthase (brain)
chr5_+_117841839 2.357 ENSMUST00000142742.2
Nos1
nitric oxide synthase 1, neuronal
chr13_-_84064772 2.224 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr4_+_144893127 1.980 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_+_104287855 1.194 ENSMUST00000065766.6
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr5_-_62766153 1.184 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_35074485 1.157 ENSMUST00000007259.3
Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr3_-_49757257 1.056 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr9_+_50575273 1.053 ENSMUST00000059081.6
ENSMUST00000180021.1
Il18

interleukin 18

chr7_-_73537621 1.002 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr16_-_23988852 0.986 ENSMUST00000023151.5
Bcl6
B cell leukemia/lymphoma 6
chr1_-_45503282 0.963 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr9_-_44799179 0.909 ENSMUST00000114705.1
ENSMUST00000002100.7
Tmem25

transmembrane protein 25

chr3_-_63851251 0.903 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
Plch1


phospholipase C, eta 1


chr14_+_13454010 0.882 ENSMUST00000112656.2
Synpr
synaptoporin
chr15_-_58214882 0.838 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr2_-_36104060 0.803 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr2_+_73271925 0.772 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr9_-_116175318 0.763 ENSMUST00000061101.4
ENSMUST00000035014.6
Tgfbr2

transforming growth factor, beta receptor II

chrX_+_169685191 0.721 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr5_-_111761697 0.694 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr2_-_144527341 0.682 ENSMUST00000163701.1
ENSMUST00000081982.5
Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr14_+_13453937 0.625 ENSMUST00000153954.1
Synpr
synaptoporin
chr3_+_89266552 0.602 ENSMUST00000040824.1
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr6_-_136875794 0.578 ENSMUST00000032342.1
Mgp
matrix Gla protein
chr4_-_42661893 0.569 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr1_-_163289214 0.532 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr1_+_191025350 0.450 ENSMUST00000181050.1
A230020J21Rik
RIKEN cDNA A230020J21 gene
chr15_+_85510812 0.430 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr5_+_71699918 0.427 ENSMUST00000031122.7
Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr7_-_139582790 0.418 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr3_-_146770218 0.412 ENSMUST00000106137.1
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr4_+_11758147 0.402 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr15_+_81936753 0.383 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr8_-_47352348 0.373 ENSMUST00000110367.2
Stox2
storkhead box 2
chr18_-_6490808 0.364 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr13_-_106847267 0.357 ENSMUST00000057427.4
Lrrc70
leucine rich repeat containing 70
chr11_-_79504078 0.352 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr8_-_41016295 0.350 ENSMUST00000131965.1
Mtus1
mitochondrial tumor suppressor 1
chr19_-_56548122 0.344 ENSMUST00000026063.5
ENSMUST00000182276.1
Dclre1a

DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)

chr11_+_94211431 0.334 ENSMUST00000041589.5
Tob1
transducer of ErbB-2.1
chr15_+_25773985 0.328 ENSMUST00000125667.1
Myo10
myosin X
chr1_+_159737510 0.318 ENSMUST00000111669.3
Tnr
tenascin R
chr15_+_81936911 0.280 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr8_+_83666827 0.278 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr17_-_78684262 0.277 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr19_+_55894508 0.271 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr19_-_56548013 0.268 ENSMUST00000182059.1
Dclre1a
DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)
chrM_+_3906 0.267 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr9_+_37208291 0.262 ENSMUST00000034632.8
Tmem218
transmembrane protein 218
chr2_+_80315461 0.237 ENSMUST00000028392.7
Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr18_-_42899294 0.237 ENSMUST00000117687.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_-_42899470 0.219 ENSMUST00000120632.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr2_-_26122769 0.209 ENSMUST00000140993.1
ENSMUST00000028300.5
Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr7_+_103550368 0.206 ENSMUST00000106888.1
Olfr613
olfactory receptor 613
chr14_+_124005355 0.202 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr6_-_124965403 0.160 ENSMUST00000129446.1
ENSMUST00000032220.8
Cops7a

COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)

chr6_-_124965485 0.153 ENSMUST00000112439.2
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr5_-_62765618 0.152 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_-_94012558 0.149 ENSMUST00000053766.6
Amfr
autocrine motility factor receptor
chr17_-_46680870 0.143 ENSMUST00000165007.1
ENSMUST00000071841.5
Klhdc3

kelch domain containing 3

chr1_+_179961110 0.143 ENSMUST00000076687.5
ENSMUST00000097450.3
Cdc42bpa

CDC42 binding protein kinase alpha

chr1_+_63176818 0.140 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr3_+_31902666 0.131 ENSMUST00000119970.1
ENSMUST00000178668.1
Kcnmb2

potassium large conductance calcium-activated channel, subfamily M, beta member 2

chr11_-_97700327 0.131 ENSMUST00000018681.7
Pcgf2
polycomb group ring finger 2
chr1_+_179960472 0.122 ENSMUST00000097453.2
ENSMUST00000111117.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr8_-_18741542 0.119 ENSMUST00000033846.6
Angpt2
angiopoietin 2
chr17_+_46681038 0.098 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr18_-_15063560 0.096 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr9_-_21287953 0.089 ENSMUST00000184326.1
ENSMUST00000038671.3
Kri1

KRI1 homolog (S. cerevisiae)

chr3_+_32436151 0.084 ENSMUST00000029201.7
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr13_+_24943144 0.079 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr11_-_109472611 0.079 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr19_+_56548254 0.073 ENSMUST00000071423.5
Nhlrc2
NHL repeat containing 2
chr14_-_54686060 0.072 ENSMUST00000125265.1
Acin1
apoptotic chromatin condensation inducer 1
chr1_+_17601893 0.069 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr4_-_133967296 0.066 ENSMUST00000105893.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr7_-_30729505 0.060 ENSMUST00000006478.8
Tmem147
transmembrane protein 147
chr1_+_180111339 0.053 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr7_-_29906087 0.053 ENSMUST00000053521.8
Zfp27
zinc finger protein 27
chr6_-_124965248 0.052 ENSMUST00000129976.1
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr8_-_111992258 0.047 ENSMUST00000034427.5
ENSMUST00000139820.1
Adat1

adenosine deaminase, tRNA-specific 1

chr2_+_130576170 0.041 ENSMUST00000028764.5
Oxt
oxytocin
chr17_-_90088343 0.032 ENSMUST00000173917.1
Nrxn1
neurexin I
chr3_+_108591279 0.023 ENSMUST00000051145.8
ENSMUST00000139626.1
Wdr47

WD repeat domain 47

chr1_+_189728264 0.016 ENSMUST00000097442.2
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr13_-_91388079 0.013 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr11_-_84067063 0.002 ENSMUST00000108101.1
Dusp14
dual specificity phosphatase 14
chr19_-_50678642 0.002 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr8_+_25720054 0.002 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 7.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.6 2.4 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.4 1.1 GO:0001866 NK T cell proliferation(GO:0001866) regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.3 1.0 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.3 1.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.8 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 0.8 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.2 2.0 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.3 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 0.6 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.5 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.3 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.0 0.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 1.2 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.2 GO:0032196 transposition(GO:0032196)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:0010986 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986)
0.0 0.4 GO:0010388 cullin deneddylation(GO:0010388)
0.0 0.4 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.2 GO:0035904 aorta development(GO:0035904)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.0 GO:0042713 negative regulation of urine volume(GO:0035811) sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.2 2.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 1.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 0.6 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.3 GO:0072534 perineuronal net(GO:0072534)
0.1 6.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 1.0 GO:0005657 replication fork(GO:0005657)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 7.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.8 2.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 2.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.6 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 1.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 0.3 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.6 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.5 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.3 GO:0046625 sphingolipid binding(GO:0046625)
0.0 1.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)