Motif ID: Hoxc10

Z-value: 0.549


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Showing 1 to 20 of 91 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_25469742 3.797 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 3.164 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr5_+_117841839 2.357 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr13_-_84064772 2.224 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_+_144893127 1.980 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_+_104287855 1.194 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr5_-_62766153 1.184 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_35074485 1.157 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr3_-_49757257 1.056 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr9_+_50575273 1.053 ENSMUST00000059081.6
ENSMUST00000180021.1
 Il18

interleukin 18

chr7_-_73537621 1.002 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr16_-_23988852 0.986 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr1_-_45503282 0.963 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr9_-_44799179 0.909 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr3_-_63851251 0.903 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
 Plch1


phospholipase C, eta 1


chr14_+_13454010 0.882 ENSMUST00000112656.2
 Synpr
synaptoporin
chr15_-_58214882 0.838 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr2_-_36104060 0.803 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr2_+_73271925 0.772 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr9_-_116175318 0.763 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 7.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.6 2.4 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.2 2.0 GO:0042572 retinol metabolic process(GO:0042572)
0.0 1.2 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 1.2 GO:0035904 aorta development(GO:0035904)
0.4 1.1 GO:0001866 NK T cell proliferation(GO:0001866) regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.1 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 1.0 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.3 1.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.3 0.8 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 0.8 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.1 0.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.6 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.5 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.0 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 2.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 1.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 1.0 GO:0005657 replication fork(GO:0005657)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 0.6 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.3 GO:0072534 perineuronal net(GO:0072534)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 7.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.8 2.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 2.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.6 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.6 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.5 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.3 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.3 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)