Motif ID: Hoxc4_Arx_Otp_Esx1_Phox2b
Z-value: 0.739
Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Arx | ENSMUSG00000035277.9 | Arx |
Esx1 | ENSMUSG00000023443.7 | Esx1 |
Hoxc4 | ENSMUSG00000075394.3 | Hoxc4 |
Otp | ENSMUSG00000021685.10 | Otp |
Phox2b | ENSMUSG00000012520.8 | Phox2b |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Otp | mm10_v2_chr13_+_94875600_94875611 | 0.60 | 2.3e-03 | Click! |
Arx | mm10_v2_chrX_+_93286499_93286522 | 0.07 | 7.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.6 | GO:0010749 | regulation of nitric oxide mediated signal transduction(GO:0010749) |
0.5 | 1.8 | GO:0043987 | histone H3-S10 phosphorylation(GO:0043987) |
0.4 | 1.1 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
0.3 | 1.4 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
0.3 | 1.0 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
0.3 | 1.4 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.3 | 4.8 | GO:0080111 | DNA demethylation(GO:0080111) |
0.2 | 0.6 | GO:0009106 | lipoate metabolic process(GO:0009106) |
0.2 | 0.5 | GO:0046098 | regulation of primitive erythrocyte differentiation(GO:0010725) guanine metabolic process(GO:0046098) |
0.2 | 3.1 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
0.2 | 2.0 | GO:0036376 | sodium ion export from cell(GO:0036376) |
0.2 | 0.6 | GO:0046950 | cellular ketone body metabolic process(GO:0046950) |
0.1 | 0.4 | GO:0060489 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
0.1 | 0.9 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.1 | 1.0 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
0.1 | 2.5 | GO:0007530 | sex determination(GO:0007530) |
0.1 | 1.8 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
0.1 | 2.2 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
0.1 | 0.4 | GO:0072592 | regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592) |
0.1 | 0.3 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
0.1 | 0.7 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
0.1 | 0.3 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
0.1 | 0.5 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
0.1 | 0.5 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.1 | 0.5 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
0.1 | 0.2 | GO:0061738 | late endosomal microautophagy(GO:0061738) |
0.1 | 0.2 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
0.1 | 0.4 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
0.1 | 0.5 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
0.1 | 0.6 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.1 | 0.1 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
0.1 | 3.3 | GO:0051693 | actin filament capping(GO:0051693) |
0.1 | 0.5 | GO:0072539 | T-helper 17 cell differentiation(GO:0072539) |
0.1 | 2.5 | GO:0007616 | long-term memory(GO:0007616) |
0.1 | 0.9 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
0.1 | 0.9 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
0.1 | 0.3 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
0.1 | 0.7 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
0.1 | 1.9 | GO:0021591 | ventricular system development(GO:0021591) |
0.0 | 1.0 | GO:0002183 | cytoplasmic translational initiation(GO:0002183) |
0.0 | 0.3 | GO:1900116 | sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
0.0 | 0.1 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
0.0 | 0.1 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
0.0 | 0.8 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
0.0 | 0.2 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.0 | 0.3 | GO:0019532 | oxalate transport(GO:0019532) |
0.0 | 0.5 | GO:0006337 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) |
0.0 | 0.1 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
0.0 | 0.2 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
0.0 | 0.1 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
0.0 | 0.1 | GO:0036337 | Fas signaling pathway(GO:0036337) |
0.0 | 0.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 2.5 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.0 | 0.3 | GO:0060373 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
0.0 | 1.1 | GO:1901381 | positive regulation of potassium ion transmembrane transport(GO:1901381) |
0.0 | 0.3 | GO:0001675 | acrosome assembly(GO:0001675) |
0.0 | 0.1 | GO:0033762 | response to glucagon(GO:0033762) |
0.0 | 0.9 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
0.0 | 0.6 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
0.0 | 0.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 0.5 | GO:0006907 | pinocytosis(GO:0006907) |
0.0 | 0.0 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) |
0.0 | 0.1 | GO:0090148 | membrane fission(GO:0090148) |
0.0 | 0.1 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.0 | 0.2 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
0.0 | 0.2 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
0.0 | 0.1 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.0 | 0.1 | GO:0052695 | cellular glucuronidation(GO:0052695) |
0.0 | 0.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 0.2 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.0 | 0.1 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
0.0 | 0.8 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
0.0 | 0.4 | GO:0006221 | pyrimidine nucleotide biosynthetic process(GO:0006221) |
0.0 | 4.0 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
0.0 | 0.1 | GO:0061436 | establishment of skin barrier(GO:0061436) |
0.0 | 0.1 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 1.1 | GO:2000177 | regulation of neural precursor cell proliferation(GO:2000177) |
0.0 | 0.2 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
0.0 | 0.0 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.0 | GO:0042585 | germinal vesicle(GO:0042585) |
0.5 | 1.8 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) |
0.3 | 2.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) dendritic spine neck(GO:0044326) |
0.1 | 0.5 | GO:0097413 | Lewy body(GO:0097413) |
0.1 | 0.4 | GO:0060187 | cell pole(GO:0060187) |
0.1 | 1.0 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.1 | 0.4 | GO:0071438 | NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438) |
0.1 | 1.7 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.1 | 0.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.1 | 0.5 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
0.1 | 0.7 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
0.1 | 0.5 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.1 | 1.8 | GO:0002102 | podosome(GO:0002102) |
0.1 | 0.2 | GO:0031417 | NatC complex(GO:0031417) |
0.1 | 0.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
0.1 | 0.3 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
0.0 | 1.1 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
0.0 | 1.5 | GO:0043034 | costamere(GO:0043034) |
0.0 | 1.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.0 | 0.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 0.6 | GO:0031527 | filopodium membrane(GO:0031527) |
0.0 | 0.3 | GO:0098536 | deuterosome(GO:0098536) |
0.0 | 1.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 0.4 | GO:0034709 | methylosome(GO:0034709) |
0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 1.9 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 0.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 3.4 | GO:0000792 | heterochromatin(GO:0000792) |
0.0 | 1.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 0.4 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.0 | 0.4 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
0.0 | 0.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
0.0 | 0.1 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 0.0 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.0 | 0.2 | GO:0048188 | MLL3/4 complex(GO:0044666) Set1C/COMPASS complex(GO:0048188) |
0.0 | 0.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.0 | 1.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 0.1 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 0.5 | GO:0030286 | dynein complex(GO:0030286) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.8 | GO:0005113 | patched binding(GO:0005113) |
0.3 | 1.0 | GO:0031779 | melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782) |
0.3 | 2.0 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
0.3 | 2.3 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.3 | 2.0 | GO:0103116 | alpha-D-galactofuranose transporter activity(GO:0103116) |
0.2 | 0.6 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
0.2 | 1.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.2 | 0.6 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
0.2 | 0.5 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
0.1 | 0.4 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.1 | 4.8 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
0.1 | 1.1 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.1 | 0.5 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
0.1 | 0.5 | GO:0008142 | oxysterol binding(GO:0008142) |
0.1 | 1.1 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
0.1 | 1.4 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.1 | 0.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.1 | 0.3 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.1 | 0.8 | GO:0050692 | DBD domain binding(GO:0050692) |
0.1 | 0.4 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
0.1 | 2.5 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.5 | GO:0034452 | dynactin binding(GO:0034452) |
0.1 | 0.5 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 0.3 | GO:0036122 | BMP binding(GO:0036122) |
0.0 | 0.1 | GO:0052740 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
0.0 | 0.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
0.0 | 2.5 | GO:0005179 | hormone activity(GO:0005179) |
0.0 | 0.9 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.3 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.0 | 0.2 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
0.0 | 0.4 | GO:0004889 | acetylcholine-activated cation-selective channel activity(GO:0004889) |
0.0 | 0.3 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
0.0 | 1.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 2.0 | GO:0005080 | protein kinase C binding(GO:0005080) |
0.0 | 0.3 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.0 | 0.4 | GO:0042556 | cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
0.0 | 0.4 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
0.0 | 0.6 | GO:0003774 | motor activity(GO:0003774) |
0.0 | 0.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 1.0 | GO:0031369 | translation initiation factor binding(GO:0031369) |
0.0 | 0.1 | GO:0032184 | SUMO polymer binding(GO:0032184) |
0.0 | 0.0 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
0.0 | 0.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.0 | 4.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 0.6 | GO:0016415 | octanoyltransferase activity(GO:0016415) |
0.0 | 1.1 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 0.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.2 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
0.0 | 0.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
0.0 | 0.1 | GO:0050733 | RS domain binding(GO:0050733) |
0.0 | 6.0 | GO:0003779 | actin binding(GO:0003779) |
0.0 | 0.2 | GO:0035380 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677) |
0.0 | 0.3 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.0 | 0.1 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
0.0 | 0.2 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.0 | 0.7 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
0.0 | 0.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |