Motif ID: Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.739

Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b:

Gene SymbolEntrez IDGene Name
Arx ENSMUSG00000035277.9 Arx
Esx1 ENSMUSG00000023443.7 Esx1
Hoxc4 ENSMUSG00000075394.3 Hoxc4
Otp ENSMUSG00000021685.10 Otp
Phox2b ENSMUSG00000012520.8 Phox2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otpmm10_v2_chr13_+_94875600_948756110.602.3e-03Click!
Arxmm10_v2_chrX_+_93286499_932865220.077.6e-01Click!


Activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b.

activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b


Sorted Z-values histogram for motif Hoxc4_Arx_Otp_Esx1_Phox2b

Sorted Z-values for motif Hoxc4_Arx_Otp_Esx1_Phox2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_8948608 5.574 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr17_-_48432723 4.753 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr9_+_119063429 3.439 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr19_-_29334646 2.566 ENSMUST00000044143.5
 Rln1
relaxin 1
chrX_-_60893430 2.465 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr13_-_102906046 2.330 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr15_-_67113909 2.320 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr7_-_25005895 2.043 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr13_-_102905740 2.021 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr2_-_168767136 2.006 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr10_+_37139558 1.964 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr10_-_37138863 1.964 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr15_-_64922290 1.961 ENSMUST00000023007.5
 Adcy8
adenylate cyclase 8
chr13_-_58354862 1.875 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr4_+_105789869 1.835 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr13_-_100786402 1.831 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr15_+_16778101 1.811 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr8_-_61902669 1.808 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr9_+_53771499 1.634 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr3_+_55782500 1.563 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0080111 DNA demethylation(GO:0080111)
0.0 4.0 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 3.3 GO:0051693 actin filament capping(GO:0051693)
0.2 3.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 2.6 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)
0.1 2.5 GO:0007530 sex determination(GO:0007530)
0.1 2.5 GO:0007616 long-term memory(GO:0007616)
0.0 2.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 2.0 GO:0036376 sodium ion export from cell(GO:0036376)
0.1 1.9 GO:0021591 ventricular system development(GO:0021591)
0.5 1.8 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.1 1.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 1.4 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.3 1.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 1.1 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 1.1 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.0 1.1 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.3 1.0 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.1 1.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0000792 heterochromatin(GO:0000792)
0.7 2.0 GO:0042585 germinal vesicle(GO:0042585)
0.3 2.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) dendritic spine neck(GO:0044326)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.5 1.8 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 1.8 GO:0002102 podosome(GO:0002102)
0.1 1.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.5 GO:0043034 costamere(GO:0043034)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.0 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.5 GO:0097413 Lewy body(GO:0097413)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0003779 actin binding(GO:0003779)
0.1 4.8 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 4.1 GO:0000287 magnesium ion binding(GO:0000287)
0.1 2.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.5 GO:0005179 hormone activity(GO:0005179)
0.3 2.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.3 2.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 2.0 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 2.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.9 GO:0003777 microtubule motor activity(GO:0003777)
0.4 1.8 GO:0005113 patched binding(GO:0005113)
0.2 1.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 1.1 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 1.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.3 1.0 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)