Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.909

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893127 9.081 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_-_84064772 8.729 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_-_154636831 6.841 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr4_+_144892813 6.286 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 4.817 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_-_49757257 4.721 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr15_+_25773985 4.262 ENSMUST00000125667.1
 Myo10
myosin X
chr17_+_3397189 3.653 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr3_+_62419668 3.578 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr5_-_62766153 3.572 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_159737510 3.282 ENSMUST00000111669.3
 Tnr
tenascin R
chr18_+_69593361 3.246 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr1_+_19103022 3.102 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr3_+_66985680 2.948 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr1_-_56969864 2.605 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr17_-_35074485 2.410 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr7_-_142661858 2.405 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr9_+_62858085 2.305 ENSMUST00000034777.6
ENSMUST00000163820.1
 Calml4

calmodulin-like 4

chr1_-_56969827 2.229 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr6_+_80018877 2.066 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 20.2 GO:0042572 retinol metabolic process(GO:0042572)
1.0 6.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 5.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 4.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 4.7 GO:0046677 response to antibiotic(GO:0046677)
0.0 3.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 3.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.1 3.3 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 3.3 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.3 3.2 GO:0042118 endothelial cell activation(GO:0042118)
0.0 2.5 GO:0031589 cell-substrate adhesion(GO:0031589)
0.3 2.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 2.4 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 2.1 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.1 2.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 2.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.6 1.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 1.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 1.7 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.1 1.6 GO:0048664 neuron fate determination(GO:0048664)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 5.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 4.2 GO:0016459 myosin complex(GO:0016459)
1.1 3.3 GO:0072534 perineuronal net(GO:0072534)
0.0 2.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 1.9 GO:0005588 collagen type V trimer(GO:0005588)
0.3 1.5 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 1.4 GO:0070820 tertiary granule(GO:0070820)
0.1 1.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.7 GO:0051233 spindle midzone(GO:0051233)
0.0 0.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.7 GO:0005720 nuclear heterochromatin(GO:0005720)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 20.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 6.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 5.0 GO:0030507 spectrin binding(GO:0030507)
0.1 4.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.3 GO:0046625 sphingolipid binding(GO:0046625)
0.8 3.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 2.4 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 2.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 2.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 1.6 GO:0071837 HMG box domain binding(GO:0071837)
0.2 1.4 GO:0045545 syndecan binding(GO:0045545)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.3 1.2 GO:0008061 chitin binding(GO:0008061)
0.3 1.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.2 GO:0019865 immunoglobulin binding(GO:0019865)