Motif ID: Hoxd12
Z-value: 1.663
Transcription factors associated with Hoxd12:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxd12 | ENSMUSG00000001823.4 | Hoxd12 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 22.1 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 3.5 | 38.5 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.9 | 5.7 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 1.8 | 12.6 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 1.5 | 6.0 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 1.2 | 19.2 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 1.1 | 3.3 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.8 | 6.8 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.8 | 5.3 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.6 | 3.8 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.6 | 1.8 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.6 | 1.7 | GO:0061043 | regulation of vascular wound healing(GO:0061043) |
| 0.4 | 4.0 | GO:0007379 | segment specification(GO:0007379) |
| 0.3 | 5.3 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.3 | 1.5 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.3 | 3.0 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.3 | 10.4 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 3.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.2 | 1.0 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.2 | 2.1 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.2 | 2.6 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.2 | 1.0 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
| 0.2 | 6.2 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.2 | 1.2 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.2 | 1.1 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.2 | 2.1 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.1 | 1.1 | GO:2000809 | positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.1 | 1.7 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 0.5 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 5.6 | GO:0030901 | midbrain development(GO:0030901) |
| 0.1 | 0.4 | GO:0021764 | amygdala development(GO:0021764) |
| 0.1 | 2.5 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 0.9 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.4 | GO:0002339 | B cell selection(GO:0002339) |
| 0.1 | 1.9 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.1 | 1.1 | GO:1900153 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153) |
| 0.1 | 0.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.5 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.0 | 0.1 | GO:0010986 | complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.0 | 0.8 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.3 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.0 | 0.3 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.0 | 0.1 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.0 | 2.6 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.1 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.0 | 0.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 1.0 | GO:0016575 | histone deacetylation(GO:0016575) |
| 0.0 | 0.6 | GO:0045471 | response to ethanol(GO:0045471) |
| 0.0 | 0.0 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.2 | GO:0032148 | activation of protein kinase B activity(GO:0032148) |
| 0.0 | 0.8 | GO:0030316 | osteoclast differentiation(GO:0030316) |
| 0.0 | 0.3 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 1.0 | GO:0014065 | phosphatidylinositol 3-kinase signaling(GO:0014065) |
| 0.0 | 1.6 | GO:0022409 | positive regulation of cell-cell adhesion(GO:0022409) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.7 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 1.3 | 22.1 | GO:0043205 | fibril(GO:0043205) |
| 1.1 | 3.3 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.1 | 5.3 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.8 | 6.8 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.3 | 6.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 1.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 12.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 18.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 3.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 3.0 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 0.6 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 4.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 0.8 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 0.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.9 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.0 | 3.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 1.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 11.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 5.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 1.0 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 38.5 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 4.4 | 22.1 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.7 | 3.0 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.6 | 1.7 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.3 | 3.8 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.2 | 5.9 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.2 | 1.0 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.2 | 1.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.2 | 3.3 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.2 | 6.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 1.1 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 5.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 2.6 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.2 | 8.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.2 | 1.1 | GO:1990188 | euchromatin binding(GO:1990188) |
| 0.1 | 12.5 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 2.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 5.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 1.9 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 2.1 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) |
| 0.1 | 1.8 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.1 | 0.8 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.1 | 8.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 1.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 1.1 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.9 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 0.3 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 0.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 2.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 1.0 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 1.2 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 1.0 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 1.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 17.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 2.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.7 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 0.1 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.0 | 1.1 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.0 | 0.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 3.1 | GO:0001012 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 0.0 | 0.2 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 0.2 | GO:0071949 | FAD binding(GO:0071949) |
