Motif ID: Hoxd9

Z-value: 0.587


Transcription factors associated with Hoxd9:

Gene SymbolEntrez IDGene Name
Hoxd9 ENSMUSG00000043342.8 Hoxd9



Activity profile for motif Hoxd9.

activity profile for motif Hoxd9


Sorted Z-values histogram for motif Hoxd9

Sorted Z-values for motif Hoxd9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_36811361 2.730 ENSMUST00000101534.1
Ptn
pleiotrophin
chr8_+_84723003 2.568 ENSMUST00000098571.4
G430095P16Rik
RIKEN cDNA G430095P16 gene
chr3_-_116129615 2.488 ENSMUST00000029574.8
Vcam1
vascular cell adhesion molecule 1
chr7_+_66365905 2.356 ENSMUST00000107486.1
Gm10974
predicted gene 10974
chrX_+_82948861 2.256 ENSMUST00000114000.1
Dmd
dystrophin, muscular dystrophy
chr7_-_103827922 1.819 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr3_-_49757257 1.672 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr2_-_63184253 1.478 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr5_-_77408034 1.459 ENSMUST00000163898.1
ENSMUST00000046746.6
Igfbp7

insulin-like growth factor binding protein 7

chr13_-_105271039 1.371 ENSMUST00000069686.6
Rnf180
ring finger protein 180
chr3_+_35754121 1.240 ENSMUST00000108186.1
ENSMUST00000029257.8
Atp11b

ATPase, class VI, type 11B

chr17_-_78684262 1.238 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr3_+_114030532 1.145 ENSMUST00000123619.1
ENSMUST00000092155.5
Col11a1

collagen, type XI, alpha 1

chrX_+_85048309 1.085 ENSMUST00000113991.1
ENSMUST00000113992.2
Dmd

dystrophin, muscular dystrophy

chr15_-_65014904 1.084 ENSMUST00000110100.2
Gm21961
predicted gene, 21961
chr5_-_62766153 1.079 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_63184170 1.061 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr7_+_120851183 0.997 ENSMUST00000106487.1
ENSMUST00000143322.1
ENSMUST00000106488.1
Eef2k


eukaryotic elongation factor-2 kinase


chr13_-_74376566 0.960 ENSMUST00000091481.2
Zfp72
zinc finger protein 72
chr2_+_67748212 0.949 ENSMUST00000180887.1
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr2_-_116064721 0.947 ENSMUST00000110906.2
Meis2
Meis homeobox 2
chr18_-_78206408 0.936 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr16_+_92292380 0.912 ENSMUST00000047383.3
Kcne2
potassium voltage-gated channel, Isk-related subfamily, gene 2
chr3_-_66296807 0.905 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr4_+_136143497 0.903 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr8_+_66386292 0.870 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr2_-_175131864 0.779 ENSMUST00000108929.2
Gm14399
predicted gene 14399
chrM_+_11734 0.767 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr3_+_53845086 0.698 ENSMUST00000108014.1
Gm10985
predicted gene 10985
chr1_-_163289214 0.678 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr11_+_29373618 0.671 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a

coiled coil domain containing 88A

chr1_+_180111339 0.645 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr12_+_36314160 0.617 ENSMUST00000041407.5
Sostdc1
sclerostin domain containing 1
chr14_-_100149764 0.613 ENSMUST00000097079.4
Klf12
Kruppel-like factor 12
chr19_-_29753600 0.593 ENSMUST00000175764.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr5_-_69590783 0.588 ENSMUST00000173927.1
Gnpda2
glucosamine-6-phosphate deaminase 2
chr16_-_65562686 0.548 ENSMUST00000004965.6
Chmp2b
charged multivesicular body protein 2B
chr7_+_127800604 0.539 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr19_-_56548122 0.520 ENSMUST00000026063.5
ENSMUST00000182276.1
Dclre1a

DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)

chr1_-_155099630 0.519 ENSMUST00000055322.4
Ier5
immediate early response 5
chr6_+_48537560 0.503 ENSMUST00000040361.5
Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr1_+_183388981 0.492 ENSMUST00000097043.5
Taf1a
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
chr14_-_36919314 0.476 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr8_+_71887264 0.475 ENSMUST00000034259.7
Zfp709
zinc finger protein 709
chr18_+_37400845 0.465 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr14_-_118923070 0.453 ENSMUST00000047208.5
Dzip1
DAZ interacting protein 1
chr18_+_37355271 0.437 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr1_-_140183404 0.429 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr8_-_41016295 0.397 ENSMUST00000131965.1
Mtus1
mitochondrial tumor suppressor 1
chr17_-_45474839 0.384 ENSMUST00000024731.8
Spats1
spermatogenesis associated, serine-rich 1
chr7_-_16286744 0.372 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9


coiled-coil domain containing 9


chr11_-_109472611 0.364 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr5_+_63812447 0.356 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr12_+_102128718 0.352 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr2_-_45117349 0.345 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr16_+_44943737 0.340 ENSMUST00000114622.3
ENSMUST00000166731.1
Cd200r3

CD200 receptor 3

chr19_+_56548254 0.334 ENSMUST00000071423.5
Nhlrc2
NHL repeat containing 2
chr1_+_194619815 0.326 ENSMUST00000027952.5
Plxna2
plexin A2
chr19_-_56548013 0.316 ENSMUST00000182059.1
Dclre1a
DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)
chr7_-_34313531 0.316 ENSMUST00000108074.1
4931406P16Rik
RIKEN cDNA 4931406P16 gene
chr1_+_167598384 0.312 ENSMUST00000015987.3
Rxrg
retinoid X receptor gamma
chr14_-_75754475 0.312 ENSMUST00000049168.7
Cog3
component of oligomeric golgi complex 3
chr2_+_30952955 0.308 ENSMUST00000028199.5
Tor1b
torsin family 1, member B
chr8_+_79028317 0.307 ENSMUST00000087927.4
ENSMUST00000098614.2
Zfp827

zinc finger protein 827

chr1_+_167598450 0.298 ENSMUST00000111386.1
ENSMUST00000111384.1
Rxrg

retinoid X receptor gamma

chrX_-_111697069 0.294 ENSMUST00000113422.2
ENSMUST00000038472.5
Hdx

highly divergent homeobox

chr16_+_20696175 0.273 ENSMUST00000128273.1
Fam131a
family with sequence similarity 131, member A
chr15_-_37459327 0.252 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr16_-_45693658 0.238 ENSMUST00000114562.2
ENSMUST00000036617.7
Tmprss7

transmembrane serine protease 7

chr6_+_145934113 0.238 ENSMUST00000032383.7
Sspn
sarcospan
chr3_+_32436376 0.229 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr2_-_58052832 0.229 ENSMUST00000090940.5
Ermn
ermin, ERM-like protein
chr9_-_78109020 0.227 ENSMUST00000001402.7
Fbxo9
f-box protein 9
chr5_-_62765618 0.223 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_84425258 0.177 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr16_+_10835046 0.158 ENSMUST00000037913.8
Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr15_+_39006272 0.145 ENSMUST00000179165.1
ENSMUST00000022906.7
Fzd6

frizzled homolog 6 (Drosophila)

chr19_+_46689902 0.126 ENSMUST00000074912.7
2010012O05Rik
RIKEN cDNA 2010012O05 gene
chr10_+_75037066 0.126 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr19_-_57197377 0.126 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr17_+_47649621 0.123 ENSMUST00000145314.1
Usp49
ubiquitin specific peptidase 49
chr16_-_50330987 0.122 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr19_-_57197496 0.121 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chr2_+_11172080 0.119 ENSMUST00000114853.1
Prkcq
protein kinase C, theta
chr19_-_57197435 0.109 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chr1_-_24612700 0.108 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr7_-_29906524 0.105 ENSMUST00000159920.1
ENSMUST00000162592.1
Zfp27

zinc finger protein 27

chr7_+_30565410 0.104 ENSMUST00000043850.7
Igflr1
IGF-like family receptor 1
chr18_+_32067729 0.090 ENSMUST00000025243.3
Iws1
IWS1 homolog (S. cerevisiae)
chr4_+_100776664 0.082 ENSMUST00000030257.8
ENSMUST00000097955.2
Cachd1

cache domain containing 1

chr1_+_180330470 0.067 ENSMUST00000070181.6
Itpkb
inositol 1,4,5-trisphosphate 3-kinase B
chr1_+_58445151 0.063 ENSMUST00000087521.6
ENSMUST00000114337.1
Nif3l1

Ngg1 interacting factor 3-like 1 (S. pombe)

chr11_+_110968016 0.044 ENSMUST00000106636.1
ENSMUST00000180023.1
Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr3_-_88772578 0.030 ENSMUST00000090945.4
Syt11
synaptotagmin XI
chr12_+_59129720 0.018 ENSMUST00000175912.1
ENSMUST00000176892.1
Ctage5

CTAGE family, member 5

chr13_+_58281183 0.014 ENSMUST00000180882.1
ENSMUST00000180452.1
Gm26555

predicted gene, 26555

chr3_-_65958236 0.010 ENSMUST00000029416.7
Ccnl1
cyclin L1
chr1_-_168432270 0.005 ENSMUST00000072863.4
Pbx1
pre B cell leukemia homeobox 1
chr12_+_59129757 0.005 ENSMUST00000069430.8
ENSMUST00000177370.1
Ctage5

CTAGE family, member 5

chr7_+_44384098 0.000 ENSMUST00000118962.1
ENSMUST00000118831.1
Syt3

synaptotagmin III


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0008065 establishment of blood-nerve barrier(GO:0008065) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.9 2.7 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 0.9 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.2 2.5 GO:0061032 visceral serous pericardium development(GO:0061032)
0.2 1.1 GO:0035989 tendon development(GO:0035989)
0.1 1.0 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1 0.9 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 1.4 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 0.8 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.6 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.6 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.1 1.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.9 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.3 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.5 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.7 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.2 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.5 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.1 GO:2000569 T-helper 2 cell activation(GO:0035712) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.0 0.9 GO:0071398 cellular response to fatty acid(GO:0071398)
0.0 0.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.6 GO:0007097 nuclear migration(GO:0007097)
0.0 0.3 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.4 GO:0097186 amelogenesis(GO:0097186)
0.0 1.0 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.7 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.1 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.0 0.4 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 1.5 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
0.0 0.5 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.9 GO:0008542 visual learning(GO:0008542)
0.0 2.5 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.0 GO:1904468 negative regulation of tumor necrosis factor secretion(GO:1904468)
0.0 0.3 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.5 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.5 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 3.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 2.5 GO:0002102 podosome(GO:0002102)
0.1 0.5 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 1.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 2.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.6 2.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.5 1.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.3 1.0 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.3 0.9 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 3.3 GO:0017166 dystroglycan binding(GO:0002162) vinculin binding(GO:0017166)
0.2 0.9 GO:0015265 urea channel activity(GO:0015265)
0.2 2.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.4 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.9 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 0.6 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.8 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.4 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 1.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 1.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.9 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.3 GO:0070412 R-SMAD binding(GO:0070412)