Motif ID: Hsf1

Z-value: 0.479


Transcription factors associated with Hsf1:

Gene SymbolEntrez IDGene Name
Hsf1 ENSMUSG00000022556.9 Hsf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_76477461-0.223.1e-01Click!


Activity profile for motif Hsf1.

activity profile for motif Hsf1


Sorted Z-values histogram for motif Hsf1

Sorted Z-values for motif Hsf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 112 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_70366735 1.762 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr11_-_116335384 1.338 ENSMUST00000036215.7
 Foxj1
forkhead box J1
chr8_-_45382198 1.237 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr1_+_66321708 1.009 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr10_+_86302854 1.009 ENSMUST00000132307.1
 Timp3
tissue inhibitor of metalloproteinase 3
chr5_+_30281377 0.974 ENSMUST00000101448.3
 Drc1
dynein regulatory complex subunit 1
chr2_+_157560078 0.889 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
 Nnat







neuronatin







chr1_+_57774600 0.829 ENSMUST00000167971.1
ENSMUST00000170139.1
ENSMUST00000171699.1
ENSMUST00000164302.1
 Spats2l



spermatogenesis associated, serine-rich 2-like



chr1_+_57774842 0.655 ENSMUST00000167085.1
 Spats2l
spermatogenesis associated, serine-rich 2-like
chr4_+_40722461 0.653 ENSMUST00000030118.3
 Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr14_-_48667508 0.637 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr9_+_18292267 0.635 ENSMUST00000001825.7
 Chordc1
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
chr5_+_115908644 0.607 ENSMUST00000141101.1
 Cit
citron
chr19_-_7039987 0.551 ENSMUST00000025918.7
 Stip1
stress-induced phosphoprotein 1
chr5_-_149636164 0.536 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr17_-_50094277 0.506 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr11_-_116843449 0.498 ENSMUST00000047616.3
 Jmjd6
jumonji domain containing 6
chr11_+_6560183 0.492 ENSMUST00000109722.2
 Ccm2
cerebral cavernous malformation 2
chr1_+_66322102 0.481 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr16_-_87495704 0.473 ENSMUST00000176750.1
ENSMUST00000175977.1
 Cct8

chaperonin containing Tcp1, subunit 8 (theta)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.8 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.2 1.8 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0 1.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.3 1.3 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.2 1.3 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1 1.1 GO:0061083 regulation of protein refolding(GO:0061083)
0.3 1.0 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 1.0 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.2 0.9 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.1 0.9 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.9 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.2 0.7 GO:0030576 Cajal body organization(GO:0030576)
0.2 0.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.6 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 0.6 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.6 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.2 0.5 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.1 0.5 GO:0007412 axon target recognition(GO:0007412)
0.1 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.5 GO:0043654 recognition of apoptotic cell(GO:0043654)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 1.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 1.3 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 0.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.5 GO:0032564 dATP binding(GO:0032564)
0.2 1.8 GO:0001972 retinoic acid binding(GO:0001972)
0.2 1.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 1.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 1.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 0.7 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.1 0.6 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.5 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.5 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.1 0.5 GO:0043559 insulin binding(GO:0043559)
0.1 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.4 GO:0046790 virion binding(GO:0046790)
0.0 0.4 GO:0031432 titin binding(GO:0031432)
0.0 0.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)