Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 3.769

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.692.8e-04Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.491.8e-02Click!
Irf2mm10_v2_chr8_+_46739745_467397910.472.3e-02Click!
Irf7mm10_v2_chr7_-_141266415_1412664810.378.2e-02Click!
Irf9mm10_v2_chr14_+_55604550_55604579-0.019.8e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 32.379 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3027439 29.718 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr2_-_98667264 28.943 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3017408 28.785 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3023547 28.743 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3034599 27.678 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3015654 27.048 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr1_-_173942445 26.888 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr9_+_3000922 26.578 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3037111 24.921 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr14_-_19418930 24.600 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3004457 23.963 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3036877 23.481 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3005125 21.570 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3025417 21.270 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3018753 21.154 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr8_-_84773381 15.809 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr11_+_119393060 13.779 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr12_+_103434211 13.374 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr2_+_98662227 13.373 ENSMUST00000099684.3
 Gm10801
predicted gene 10801

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 44.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.9 26.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.8 24.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 24.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.0 14.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.4 13.6 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 12.9 GO:0016579 protein deubiquitination(GO:0016579)
0.3 12.6 GO:0046825 regulation of protein export from nucleus(GO:0046825)
4.1 12.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
3.8 11.4 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
3.6 10.8 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
2.6 10.5 GO:0009597 detection of virus(GO:0009597)
0.0 9.0 GO:0006914 autophagy(GO:0006914)
0.7 8.5 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
1.9 7.5 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.0 7.0 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
1.3 6.7 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.6 5.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.6 4.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
1.4 4.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 210.6 GO:0005575 cellular_component(GO:0005575)
1.4 18.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 17.3 GO:0005770 late endosome(GO:0005770)
0.3 14.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 13.6 GO:0005730 nucleolus(GO:0005730)
0.1 11.0 GO:0016363 nuclear matrix(GO:0016363)
3.6 10.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 10.6 GO:0032587 ruffle membrane(GO:0032587)
0.2 7.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 7.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.5 7.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 6.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.6 5.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.3 3.8 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.2 3.5 GO:0031527 filopodium membrane(GO:0031527)
0.5 3.2 GO:0042825 TAP complex(GO:0042825)
0.3 2.3 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.3 GO:0030914 STAGA complex(GO:0030914)
0.0 2.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 45.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 20.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.9 17.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 14.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.6 14.2 GO:0005521 lamin binding(GO:0005521)
0.1 12.8 GO:0008083 growth factor activity(GO:0008083)
1.3 12.6 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
1.0 12.4 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.7 10.5 GO:0046977 TAP binding(GO:0046977)
3.4 10.3 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 8.5 GO:0005525 GTP binding(GO:0005525)
0.0 7.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 6.7 GO:0046332 SMAD binding(GO:0046332)
0.5 6.5 GO:0031386 protein tag(GO:0031386)
0.1 5.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 5.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 4.8 GO:0070412 R-SMAD binding(GO:0070412)
1.2 4.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.5 4.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.0 4.0 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)